DOP2003000603A - OXO-AZABICICLIC COMPOUNDS - Google Patents
OXO-AZABICICLIC COMPOUNDSInfo
- Publication number
- DOP2003000603A DOP2003000603A DO2003000603A DO2003000603A DOP2003000603A DO P2003000603 A DOP2003000603 A DO P2003000603A DO 2003000603 A DO2003000603 A DO 2003000603A DO 2003000603 A DO2003000603 A DO 2003000603A DO P2003000603 A DOP2003000603 A DO P2003000603A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- group
- inclusive
- integer
- alkyl
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un compuesto seleccionado de aquellos de la formula (I): en donde: X1, X2 y X3 representan N o -CR3 en donde R3 es lo descripto en la memoria descriptiva, G1 representa un grupo seleccionado de aquellos de las formulas (i/a) e (i/b): en donde R4, R5, y R6 son lo definido anteriormente, G2 representa un grupo seleccionado de enlace triple de carbono-carbono, -CH=C=CH-, C=O, C=S, S(O), n1 en donde nl representa un numero entero de 0 a 2 inclusive, y un grupo de la formula (i/c): en donde Y1 representa 0, S, -NH o -N alquilo e Y2 representa 0, S, -NH o -N alquilo, n es un numero entero de 0 a 6 inclusive, y m es un numero entero de 0 a 7 inclusive, Z1 representa -CR9R10, en donde R9 y R10 son lo definido en la memoria descriptiva, A representa un sistema de anillo, R1 representa un grupo seleccionado de H, alquilo, alquenilo, alquinilo, optativamente sustituido y el grupo de la formula (i/d): en donde p, Z2, B, q y G2 son lo definido en la memoria descriptiva y optativamente, sus isomeros opticos, N-oxidos y sales de ellos con el acido o base farmaceuticamente aceptable, y productos medicinales que contienen los mismos son utiles como inhibidores especificos de la metaloproteasa de la matriz de tipo 13.A compound selected from those of the formula (I): where: X1, X2 and X3 represent N or -CR3 where R3 is as described in the specification, G1 represents a group selected from those of the formulas (i / a ) e (i / b): where R4, R5, and R6 are defined above, G2 represents a selected group of carbon-carbon triple bond, -CH = C = CH-, C = O, C = S, S (O), n1 where nl represents an integer from 0 to 2 inclusive, and a group of the formula (i / c): where Y1 represents 0, S, -NH or -N alkyl and Y2 represents 0, S, -NH or -N alkyl, n is an integer from 0 to 6 inclusive, and m is an integer from 0 to 7 inclusive, Z1 represents -CR9R10, where R9 and R10 are defined in the specification, A represents a ring system, R1 represents a group selected from H, alkyl, alkenyl, alkynyl, optionally substituted and the group of the formula (i / d): wherein p, Z2, B, q and G2 are defined herein. descriptively and optionally, its isomers optics, N-oxides and salts thereof with the pharmaceutically acceptable acid or base, and medicinal products containing them are useful as specific inhibitors of type 13 matrix metalloprotease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DO2003000603A DOP2003000603A (en) | 2003-03-06 | 2003-03-06 | OXO-AZABICICLIC COMPOUNDS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DO2003000603A DOP2003000603A (en) | 2003-03-06 | 2003-03-06 | OXO-AZABICICLIC COMPOUNDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2003000603A true DOP2003000603A (en) | 2003-11-30 |
Family
ID=44261162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2003000603A DOP2003000603A (en) | 2003-03-06 | 2003-03-06 | OXO-AZABICICLIC COMPOUNDS |
Country Status (1)
| Country | Link |
|---|---|
| DO (1) | DOP2003000603A (en) |
-
2003
- 2003-03-06 DO DO2003000603A patent/DOP2003000603A/en unknown
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