DOP2015000295A - Composiciones farmacéuticas de triazolopiridinas sustituidas, metodos para prepararlas y sus usos - Google Patents
Composiciones farmacéuticas de triazolopiridinas sustituidas, metodos para prepararlas y sus usosInfo
- Publication number
- DOP2015000295A DOP2015000295A DO2015000295A DO2015000295A DOP2015000295A DO P2015000295 A DOP2015000295 A DO P2015000295A DO 2015000295 A DO2015000295 A DO 2015000295A DO 2015000295 A DO2015000295 A DO 2015000295A DO P2015000295 A DOP2015000295 A DO P2015000295A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- pharmaceutical compositions
- methods
- triazolopiridins
- prepare
- replaced
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 150000008523 triazolopyridines Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención provee composiciones farmacéuticas que comprenden un compuesto del tipo de las triazolopiridinas sustituidas de fórmula general (I) : I), o una sal, hidrato o solvato del mismo, el cual es un inhibidor muy efectivo de Mps-1 quinasa, y una matriz capaz de disolver o dispersar dicho compuesto. La presente invención además se relaciona con métodos para preparar composiciones farmacéuticas, y con el uso de dichas composiciones farmacéuticas para el tratamiento o profilaxis de una enfermedad, como por ejemplo trastornos de hiperproliferación.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13170754 | 2013-06-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2015000295A true DOP2015000295A (es) | 2016-03-15 |
Family
ID=48569985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2015000295A DOP2015000295A (es) | 2013-06-06 | 2015-12-04 | Composiciones farmacéuticas de triazolopiridinas sustituidas, metodos para prepararlas y sus usos |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US20160120854A1 (es) |
| EP (1) | EP3003381B1 (es) |
| JP (1) | JP2016523229A (es) |
| KR (1) | KR20160018513A (es) |
| CN (1) | CN105263526A (es) |
| AP (1) | AP2015008890A0 (es) |
| AR (1) | AR096469A1 (es) |
| AU (1) | AU2014276870A1 (es) |
| BR (1) | BR112015030292A2 (es) |
| CA (1) | CA2914439A1 (es) |
| CL (1) | CL2015003535A1 (es) |
| CR (1) | CR20150641U (es) |
| CU (1) | CU24283B1 (es) |
| CY (1) | CY1119666T1 (es) |
| DK (1) | DK3003381T3 (es) |
| DO (1) | DOP2015000295A (es) |
| EA (1) | EA201501177A1 (es) |
| ES (1) | ES2652149T3 (es) |
| HK (1) | HK1219906A1 (es) |
| HR (1) | HRP20171888T1 (es) |
| HU (1) | HUE034883T2 (es) |
| LT (1) | LT3003381T (es) |
| MA (1) | MA38642A1 (es) |
| NI (1) | NI201500172A (es) |
| NO (1) | NO3003381T3 (es) |
| PE (1) | PE20152028A1 (es) |
| PH (1) | PH12015502703A1 (es) |
| PL (1) | PL3003381T3 (es) |
| PT (1) | PT3003381T (es) |
| RS (1) | RS56666B1 (es) |
| SG (1) | SG11201509114TA (es) |
| SI (1) | SI3003381T1 (es) |
| SM (1) | SMT201700573T1 (es) |
| TN (1) | TN2015000524A1 (es) |
| UY (1) | UY35600A (es) |
| WO (1) | WO2014195408A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20160156A1 (es) * | 2013-06-11 | 2016-04-20 | Bayer Pharma AG | Derivados de prodroga de triazolpiridinas sustituidas |
| TW201800408A (zh) | 2016-06-15 | 2018-01-01 | 拜耳製藥公司 | Mps-1抑制劑 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030212102A1 (en) * | 2001-06-12 | 2003-11-13 | Koretke Todd W | Novel solid dispersion compositions |
| CN101048140B (zh) * | 2004-08-27 | 2013-06-19 | 拜尔保健公司 | 用于治疗癌症的药物组合物 |
| CN101125124B (zh) * | 2006-08-16 | 2011-04-20 | 沈阳药科大学 | 一种亲脂性药物固体分散体的制备方法 |
| EP2343297A1 (en) * | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
| EP2343294A1 (en) * | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
| EP2343295A1 (en) * | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridine derivates |
| UA112096C2 (uk) * | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
| CN102512358B (zh) * | 2011-12-16 | 2013-04-10 | 南京农业大学 | 家畜用利福昔明阴道栓剂及其制备方法 |
| CN102626384A (zh) * | 2012-04-12 | 2012-08-08 | 临沂大学 | 一种姜黄素混悬剂及其制备方法 |
-
2014
- 2014-06-04 AR ARP140102174A patent/AR096469A1/es unknown
- 2014-06-05 HU HUE14728567A patent/HUE034883T2/hu unknown
- 2014-06-05 TN TN2015000524A patent/TN2015000524A1/en unknown
- 2014-06-05 EA EA201501177A patent/EA201501177A1/ru unknown
- 2014-06-05 US US14/896,329 patent/US20160120854A1/en not_active Abandoned
- 2014-06-05 AP AP2015008890A patent/AP2015008890A0/xx unknown
- 2014-06-05 JP JP2016517600A patent/JP2016523229A/ja active Pending
- 2014-06-05 SG SG11201509114TA patent/SG11201509114TA/en unknown
- 2014-06-05 AU AU2014276870A patent/AU2014276870A1/en not_active Abandoned
- 2014-06-05 DK DK14728567.0T patent/DK3003381T3/en active
- 2014-06-05 HK HK16108106.6A patent/HK1219906A1/zh unknown
- 2014-06-05 CU CUP2015000170A patent/CU24283B1/es unknown
- 2014-06-05 BR BR112015030292A patent/BR112015030292A2/pt not_active IP Right Cessation
- 2014-06-05 EP EP14728567.0A patent/EP3003381B1/en active Active
- 2014-06-05 SI SI201430508T patent/SI3003381T1/en unknown
- 2014-06-05 CA CA2914439A patent/CA2914439A1/en not_active Abandoned
- 2014-06-05 WO PCT/EP2014/061711 patent/WO2014195408A1/en not_active Ceased
- 2014-06-05 PE PE2015002552A patent/PE20152028A1/es not_active Application Discontinuation
- 2014-06-05 HR HRP20171888TT patent/HRP20171888T1/hr unknown
- 2014-06-05 PT PT147285670T patent/PT3003381T/pt unknown
- 2014-06-05 CN CN201480032089.8A patent/CN105263526A/zh active Pending
- 2014-06-05 SM SM20170573T patent/SMT201700573T1/it unknown
- 2014-06-05 PL PL14728567T patent/PL3003381T3/pl unknown
- 2014-06-05 RS RS20171238A patent/RS56666B1/sr unknown
- 2014-06-05 ES ES14728567.0T patent/ES2652149T3/es active Active
- 2014-06-05 LT LTEP14728567.0T patent/LT3003381T/lt unknown
- 2014-06-05 MA MA38642A patent/MA38642A1/fr unknown
- 2014-06-05 KR KR1020157034346A patent/KR20160018513A/ko not_active Withdrawn
- 2014-06-05 NO NO14728567A patent/NO3003381T3/no unknown
- 2014-06-06 UY UY0001035600A patent/UY35600A/es not_active Application Discontinuation
-
2015
- 2015-12-03 PH PH12015502703A patent/PH12015502703A1/en unknown
- 2015-12-03 CL CL2015003535A patent/CL2015003535A1/es unknown
- 2015-12-04 NI NI201500172A patent/NI201500172A/es unknown
- 2015-12-04 CR CR20150641U patent/CR20150641U/es unknown
- 2015-12-04 DO DO2015000295A patent/DOP2015000295A/es unknown
-
2017
- 2017-12-07 CY CY20171101289T patent/CY1119666T1/el unknown
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