DOP2017000141A - Ácido 3-(6-alcoxi-5-clorobenzo[d]isoxazol-3-il)propanoico útil como inhibidores de quinurenina monooxigenasa - Google Patents
Ácido 3-(6-alcoxi-5-clorobenzo[d]isoxazol-3-il)propanoico útil como inhibidores de quinurenina monooxigenasaInfo
- Publication number
- DOP2017000141A DOP2017000141A DO2017000141A DO2017000141A DOP2017000141A DO P2017000141 A DOP2017000141 A DO P2017000141A DO 2017000141 A DO2017000141 A DO 2017000141A DO 2017000141 A DO2017000141 A DO 2017000141A DO P2017000141 A DOP2017000141 A DO P2017000141A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- acute
- disease
- severe
- useful
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- YGPSJZOEDVAXAB-QMMMGPOBSA-N L-kynurenine Chemical compound OC(=O)[C@@H](N)CC(=O)C1=CC=CC=C1N YGPSJZOEDVAXAB-QMMMGPOBSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 230000001154 acute effect Effects 0.000 abstract 3
- 208000009304 Acute Kidney Injury Diseases 0.000 abstract 2
- 208000033626 Renal failure acute Diseases 0.000 abstract 2
- 201000011040 acute kidney failure Diseases 0.000 abstract 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 206010065040 AIDS dementia complex Diseases 0.000 abstract 1
- 208000000197 Acute Cholecystitis Diseases 0.000 abstract 1
- 208000007788 Acute Liver Failure Diseases 0.000 abstract 1
- 206010000804 Acute hepatic failure Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010008614 Cholecystitis acute Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 206010022680 Intestinal ischaemia Diseases 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 206010033647 Pancreatitis acute Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- 206010038687 Respiratory distress Diseases 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 abstract 1
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 abstract 1
- 231100000836 acute liver failure Toxicity 0.000 abstract 1
- 206010069351 acute lung injury Diseases 0.000 abstract 1
- 201000003229 acute pancreatitis Diseases 0.000 abstract 1
- 208000012998 acute renal failure Diseases 0.000 abstract 1
- 201000001352 cholecystitis Diseases 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 208000007386 hepatic encephalopathy Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000013223 septicemia Diseases 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
El compuesto de fórmula (I) en la que: R1 es heteroarilo no sustituido o sustituido con metilo, etilo, halo o =O; y R2 es H, metilo o etilo; y las sales del mismo son inhibidores de KMO y pueden ser útiles en el tratamiento de diversos trastornos, por ejemplo, pancreatitis aguda, enfermedad renal crónica, enfermedad renal aguda, lesión renal aguda, otros estados patológicos asociados con síndrome de respuesta inflamatoria sistémica (SRIS), enfermedad de Huntington, enfermedad de Alzheimer, ataxias espinocerebelosas, enfermedad de Parkinson, complejo SIDA-demencia, infección por VIH, esclerosis lateral amiotrófica (ELA), depresión, esquizofrenia, septicemia, choque cardiovascular, traumatismo grave, lesión pulmonar aguda, síndrome de dificultad respiratoria aguda, colecistitis aguda, quemaduras graves, neumonía, procedimientos quirúrgicos extensos, isquemia intestinal, insuficiencia hepática aguda grave, encefalopatía hepática aguda grave o insuficiencia renal aguda.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201422727 | 2014-12-19 | ||
| GBGB1508866.9A GB201508866D0 (en) | 2015-05-22 | 2015-05-22 | Compounds |
| PCT/EP2015/080221 WO2016097144A1 (en) | 2014-12-19 | 2015-12-17 | 3-(6-alkoxy-5-chlorobenzo[d]isoxazol-3-yl)propanoic acid useful as kynurenine monooxygenase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2017000141A true DOP2017000141A (es) | 2017-07-16 |
Family
ID=54850210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2017000141A DOP2017000141A (es) | 2014-12-19 | 2017-06-14 | Ácido 3-(6-alcoxi-5-clorobenzo[d]isoxazol-3-il)propanoico útil como inhibidores de quinurenina monooxigenasa |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US9932328B2 (es) |
| EP (1) | EP3233844B1 (es) |
| JP (1) | JP6644790B2 (es) |
| KR (1) | KR102557791B1 (es) |
| CN (1) | CN107108594B (es) |
| AU (1) | AU2015367396C1 (es) |
| BR (1) | BR112017013193B1 (es) |
| CA (1) | CA2969385C (es) |
| CL (1) | CL2017001549A1 (es) |
| CO (1) | CO2017005872A2 (es) |
| CR (1) | CR20170261A (es) |
| DO (1) | DOP2017000141A (es) |
| EA (1) | EA033632B1 (es) |
| ES (1) | ES2737893T3 (es) |
| IL (1) | IL252155B (es) |
| JO (1) | JO3656B1 (es) |
| MX (1) | MX373649B (es) |
| MY (1) | MY201861A (es) |
| NZ (1) | NZ732002A (es) |
| PE (1) | PE20171259A1 (es) |
| PH (1) | PH12017500993B1 (es) |
| SG (1) | SG11201703807VA (es) |
| TW (1) | TWI698433B (es) |
| UA (1) | UA120381C2 (es) |
| UY (1) | UY36451A (es) |
| WO (1) | WO2016097144A1 (es) |
| ZA (1) | ZA201702918B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107108594B (zh) * | 2014-12-19 | 2020-06-09 | 葛兰素史密斯克莱知识产权发展有限公司 | 用作犬尿氨酸单加氧酶抑制剂的化合物 |
| KR101684053B1 (ko) * | 2015-01-20 | 2016-12-08 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법 |
| WO2026057633A1 (en) | 2024-09-12 | 2026-03-19 | Dr. Falk Pharma Gmbh | Benzisoxazole compound for treatment of kmo mediated disorders |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9720899D0 (en) * | 1997-10-01 | 1997-12-03 | Pharmacia & Upjohn Spa | Condensed heterocyclic compounds |
| US7622495B2 (en) * | 2006-10-03 | 2009-11-24 | Neurim Pharmaceuticals (1991) Ltd. | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
| EP2152679A1 (en) * | 2007-05-24 | 2010-02-17 | NeuroSearch A/S | Benzisoxazole derivatives as potassium channel modulators for the treatment of e.g. respiratory diseases, epilepsy and convulsions |
| WO2010011302A1 (en) * | 2008-07-22 | 2010-01-28 | Chdi, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| WO2010017132A1 (en) * | 2008-08-04 | 2010-02-11 | Chdi, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| NZ601547A (en) * | 2010-01-25 | 2014-04-30 | Chdi Foundation Inc | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| WO2013033068A1 (en) * | 2011-08-30 | 2013-03-07 | Stephen Martin Courtney | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| GB201322512D0 (en) * | 2013-12-19 | 2014-02-05 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CN107108594B (zh) * | 2014-12-19 | 2020-06-09 | 葛兰素史密斯克莱知识产权发展有限公司 | 用作犬尿氨酸单加氧酶抑制剂的化合物 |
-
2015
- 2015-12-17 CN CN201580068887.0A patent/CN107108594B/zh active Active
- 2015-12-17 KR KR1020177016276A patent/KR102557791B1/ko active Active
- 2015-12-17 AU AU2015367396A patent/AU2015367396C1/en active Active
- 2015-12-17 UA UAA201707042A patent/UA120381C2/uk unknown
- 2015-12-17 JP JP2017532625A patent/JP6644790B2/ja active Active
- 2015-12-17 PE PE2017001084A patent/PE20171259A1/es unknown
- 2015-12-17 PH PH1/2017/500993A patent/PH12017500993B1/en unknown
- 2015-12-17 EP EP15810681.5A patent/EP3233844B1/en active Active
- 2015-12-17 CA CA2969385A patent/CA2969385C/en active Active
- 2015-12-17 US US15/537,805 patent/US9932328B2/en active Active
- 2015-12-17 ES ES15810681T patent/ES2737893T3/es active Active
- 2015-12-17 MY MYPI2017702244A patent/MY201861A/en unknown
- 2015-12-17 EA EA201791402A patent/EA033632B1/ru not_active IP Right Cessation
- 2015-12-17 JO JOP/2015/0324A patent/JO3656B1/ar active
- 2015-12-17 SG SG11201703807VA patent/SG11201703807VA/en unknown
- 2015-12-17 CR CR20170261A patent/CR20170261A/es unknown
- 2015-12-17 NZ NZ732002A patent/NZ732002A/en unknown
- 2015-12-17 TW TW104142406A patent/TWI698433B/zh active
- 2015-12-17 BR BR112017013193-5A patent/BR112017013193B1/pt active IP Right Grant
- 2015-12-17 UY UY0001036451A patent/UY36451A/es active IP Right Grant
- 2015-12-17 WO PCT/EP2015/080221 patent/WO2016097144A1/en not_active Ceased
- 2015-12-17 MX MX2017008069A patent/MX373649B/es active IP Right Grant
-
2017
- 2017-04-26 ZA ZA2017/02918A patent/ZA201702918B/en unknown
- 2017-05-08 IL IL252155A patent/IL252155B/en active IP Right Grant
- 2017-06-14 DO DO2017000141A patent/DOP2017000141A/es unknown
- 2017-06-14 CO CONC2017/0005872A patent/CO2017005872A2/es unknown
- 2017-06-15 CL CL2017001549A patent/CL2017001549A1/es unknown
-
2018
- 2018-02-20 US US15/900,043 patent/US10273232B2/en active Active
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