DZ2032A1 - Un procédé pour la préparation de l'hydrochlorure de lercanidipine. - Google Patents

Un procédé pour la préparation de l'hydrochlorure de lercanidipine.

Info

Publication number: DZ2032A1
Authority: DZ; Algeria
Prior art keywords: preparation; lercanidipine hydrochloride; lercanidipine; hydrochloride
Prior art date: 1995-05-12

Application number

DZ960075A

Other languages

English (en)

Inventor

Amedeo Leonardi

Giani Mota

Original Assignee

Recordati Chem Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-12

Filing date

1996-05-08

Publication date

2002-07-21

1996-05-08 Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm

2002-07-21 Application granted granted Critical

2002-07-21 Publication of DZ2032A1 publication Critical patent/DZ2032A1/fr

Links

WMFYOYKPJLRMJI-UHFFFAOYSA-N Lercanidipine hydrochloride Chemical compound Cl.COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 WMFYOYKPJLRMJI-UHFFFAOYSA-N 0.000 title 1
229960002162 lercanidipine hydrochloride Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Urology & Nephrology (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DZ960075A 1995-05-12 1996-05-08 Un procédé pour la préparation de l'hydrochlorure de lercanidipine. DZ2032A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI950957A IT1274480B (it)	1995-05-12	1995-05-12	Procedimento migliorato per la preparazione della lercanidipina cloridrato

Publications (1)

Publication Number	Publication Date
DZ2032A1 true DZ2032A1 (fr)	2002-07-21

Family

ID=11371581

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DZ960075A DZ2032A1 (fr)	1995-05-12	1996-05-08	Un procédé pour la préparation de l'hydrochlorure de lercanidipine.

Country Status (37)

Country	Link
EP (1)	EP0824517B1 (fr)
JP (1)	JP4038622B2 (fr)
KR (1)	KR100395441B1 (fr)
CN (1)	CN1101810C (fr)
AR (1)	AR002739A1 (fr)
AT (1)	ATE221050T1 (fr)
AU (1)	AU694046B2 (fr)
BG (1)	BG62400B1 (fr)
BR (1)	BR9608374A (fr)
CA (1)	CA2217849C (fr)
CZ (1)	CZ288634B6 (fr)
DE (1)	DE69622552T2 (fr)
DK (1)	DK0824517T3 (fr)
DZ (1)	DZ2032A1 (fr)
EA (1)	EA000346B1 (fr)
EE (1)	EE03351B1 (fr)
EG (1)	EG21755A (fr)
ES (1)	ES2179942T3 (fr)
HU (1)	HU226709B1 (fr)
IL (1)	IL118143A (fr)
IN (1)	IN188486B (fr)
IT (1)	IT1274480B (fr)
MA (1)	MA23858A1 (fr)
MX (1)	MX9708662A (fr)
MY (1)	MY113802A (fr)
NO (1)	NO309423B1 (fr)
NZ (1)	NZ309059A (fr)
PL (1)	PL185260B1 (fr)
PT (1)	PT824517E (fr)
RO (1)	RO119616B1 (fr)
SA (1)	SA96170216B1 (fr)
SK (1)	SK283321B6 (fr)
TN (1)	TNSN96069A1 (fr)
TW (1)	TW404940B (fr)
UA (1)	UA46769C2 (fr)
WO (1)	WO1996035668A1 (fr)
ZA (1)	ZA963716B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6852737B2 (en)	2001-08-06	2005-02-08	Recordati Ireland Limited	Crude and crystalline forms of lercanidipine hydrochloride
ITMI20011726A1 (it) *	2001-08-06	2003-02-06	Recordati Ind Chimica E Farma	Forme polimorfe della lercanidipina cloridrato
JP2006504800A (ja) *	2002-10-16	2006-02-09	レコーダチアイルランドリミテッド	リシノプリル／レルカニジピンの組み合わせ治療
AR052918A1 (es)	2005-02-25	2007-04-11	Recordati Ireland Ltd	Clorhidrato de lercanidipina amorfo
KR100713136B1 (ko) *	2005-05-04	2007-05-02	주식회사 대희화학	무수 레르카니디핀 염화수소 결정다형의 개선된 신규결정화 방법
SI1891009T1 (sl) *	2005-06-15	2010-02-26	Hetero Drugs Ltd Hetero House	Nov postopek priprave lerkanidipina
EP1940790B1 (fr)	2005-09-16	2015-09-02	Glenmark Pharmaceuticals Limited	Forme polymorphique d'hydrochlorure de lercanidipine et son procede de preparation
KR100811497B1 (ko) *	2005-10-19	2008-03-07	신풍제약주식회사	무수 염산 1,4-디하이드로피리딘 유도체의 제조 방법
EP1860102B1 (fr) *	2006-05-24	2008-11-26	CF Pharma Ltd.	Procédé pour la Preparation de Lercanipidine
KR100808281B1 (ko) *	2006-06-30	2008-03-03	주식회사 하원정밀화학	레르카니디핀 및 그 산부가염의 제조방법
CN102020602B (zh) *	2009-09-18	2013-12-25	深圳信立泰药业股份有限公司	盐酸乐卡地平晶型及其制备方法和含有该晶型的药物组合物
SI2585051T2 (sl)	2010-06-23	2020-07-31	Krka, D.D., Novo Mesto	Farmacevtske oralne odmerne oblike,ki obsegajo lerkanidipin in enalapril in njune farmacevtsko sprejemljive soli
WO2012085249A2 (fr)	2010-12-24	2012-06-28	Krka, D.D., Novo Mesto	Formes pharmaceutiques orales homogènes comprenant de la lercanidipine et de l'énalapril ou leurs sels pharmaceutiquement acceptables
CN102558032B (zh) *	2011-12-16	2014-02-26	华润赛科药业有限责任公司	一种无定形盐酸乐卡地平及其制备方法
CN102516160B (zh) *	2011-12-16	2014-04-02	华润赛科药业有限责任公司	一种高纯盐酸乐卡地平的合成工艺
CN102584682A (zh) *	2011-12-31	2012-07-18	苏州二叶制药有限公司	盐酸乐卡地平的制备方法
CN109956943B (zh) *	2019-04-18	2021-07-20	合肥合源药业有限公司	一种二氢吡啶类药物中脱羧缩合杂质及其制备、控制方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8403866D0 (en) *	1984-02-14	1984-03-21	Recordati Chem Pharm	Diphenylalkylaminoalkyl esters

1995
- 1995-05-12 IT ITMI950957A patent/IT1274480B/it active IP Right Grant
1996
- 1996-05-03 IL IL11814396A patent/IL118143A/en not_active IP Right Cessation
- 1996-05-06 IN IN822CA1996 patent/IN188486B/en unknown
- 1996-05-07 MA MA24223A patent/MA23858A1/fr unknown
- 1996-05-08 DZ DZ960075A patent/DZ2032A1/fr active
- 1996-05-09 EA EA199700374A patent/EA000346B1/ru not_active IP Right Cessation
- 1996-05-09 EP EP96916111A patent/EP0824517B1/fr not_active Expired - Lifetime
- 1996-05-09 NZ NZ309059A patent/NZ309059A/xx not_active IP Right Cessation
- 1996-05-09 CA CA002217849A patent/CA2217849C/fr not_active Expired - Lifetime
- 1996-05-09 BR BR9608374A patent/BR9608374A/pt not_active Application Discontinuation
- 1996-05-09 DK DK96916111T patent/DK0824517T3/da active
- 1996-05-09 CZ CZ19973567A patent/CZ288634B6/cs not_active IP Right Cessation
- 1996-05-09 HU HU9801913A patent/HU226709B1/hu unknown
- 1996-05-09 UA UA97125981A patent/UA46769C2/uk unknown
- 1996-05-09 AU AU58985/96A patent/AU694046B2/en not_active Expired
- 1996-05-09 WO PCT/EP1996/002122 patent/WO1996035668A1/fr not_active Ceased
- 1996-05-09 EE EE9700303A patent/EE03351B1/xx unknown
- 1996-05-09 ES ES96916111T patent/ES2179942T3/es not_active Expired - Lifetime
- 1996-05-09 PL PL96323236A patent/PL185260B1/pl unknown
- 1996-05-09 PT PT96916111T patent/PT824517E/pt unknown
- 1996-05-09 RO RO97-02101A patent/RO119616B1/ro unknown
- 1996-05-09 SK SK1514-97A patent/SK283321B6/sk not_active IP Right Cessation
- 1996-05-09 CN CN96193842A patent/CN1101810C/zh not_active Expired - Lifetime
- 1996-05-09 KR KR1019970707905A patent/KR100395441B1/ko not_active Expired - Lifetime
- 1996-05-09 AT AT96916111T patent/ATE221050T1/de active
- 1996-05-09 JP JP53379796A patent/JP4038622B2/ja not_active Expired - Lifetime
- 1996-05-09 EG EG40296A patent/EG21755A/xx active
- 1996-05-09 DE DE69622552T patent/DE69622552T2/de not_active Expired - Lifetime
- 1996-05-09 MY MYPI96001751A patent/MY113802A/en unknown
- 1996-05-10 TW TW085105567A patent/TW404940B/zh not_active IP Right Cessation
- 1996-05-10 AR ARP960102528A patent/AR002739A1/es unknown
- 1996-05-10 TN TNTNSN96069A patent/TNSN96069A1/fr unknown
- 1996-05-10 ZA ZA963716A patent/ZA963716B/xx unknown
- 1996-08-07 SA SA96170216A patent/SA96170216B1/ar unknown
1997
- 1997-11-07 BG BG102034A patent/BG62400B1/bg unknown
- 1997-11-11 MX MX9708662A patent/MX9708662A/es unknown
- 1997-11-11 NO NO975176A patent/NO309423B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0824517B1 (fr)	2002-07-24
EA199700374A1 (ru)	1998-10-29
MY113802A (en)	2002-05-31
IL118143A0 (en)	1996-09-12
BR9608374A (pt)	1999-08-24
HUP9801913A2 (hu)	1998-12-28
NO975176L (no)	1997-11-11
HUP9801913A3 (en)	1999-01-28
JP4038622B2 (ja)	2008-01-30
RO119616B1 (ro)	2005-01-28
EP0824517A1 (fr)	1998-02-25
TW404940B (en)	2000-09-11
EE03351B1 (et)	2001-02-15
PL185260B1 (pl)	2003-04-30
PL323236A1 (en)	1998-03-16
EG21755A (en)	2002-02-27
SK283321B6 (sk)	2003-06-03
DK0824517T3 (da)	2002-11-18
CA2217849C (fr)	2007-09-11
SA96170216B1 (ar)	2005-12-21
CZ356797A3 (cs)	1998-04-15
AR002739A1 (es)	1998-04-29
WO1996035668A1 (fr)	1996-11-14
BG102034A (en)	1998-04-30
DE69622552T2 (de)	2003-01-23
ES2179942T3 (es)	2003-02-01
ZA963716B (en)	1996-11-20
TNSN96069A1 (fr)	2005-03-15
AU5898596A (en)	1996-11-29
NO309423B1 (no)	2001-01-29
NZ309059A (en)	1998-10-28
CN1184468A (zh)	1998-06-10
NO975176D0 (no)	1997-11-11
CN1101810C (zh)	2003-02-19
DE69622552D1 (de)	2002-08-29
CA2217849A1 (fr)	1996-11-14
AU694046B2 (en)	1998-07-09
BG62400B1 (bg)	1999-10-29
ATE221050T1 (de)	2002-08-15
CZ288634B6 (cs)	2001-08-15
KR100395441B1 (ko)	2004-02-05
KR19990008378A (ko)	1999-01-25
MA23858A1 (fr)	1996-12-31
HU226709B1 (en)	2009-07-28
UA46769C2 (uk)	2002-06-17
ITMI950957A0 (it)	1995-05-12
IL118143A (en)	2001-06-14
EA000346B1 (ru)	1999-04-29
PT824517E (pt)	2002-12-31
IN188486B (fr)	2002-10-05
SK151497A3 (en)	1998-05-06
IT1274480B (it)	1997-07-17
ITMI950957A1 (it)	1996-11-12
JPH11504932A (ja)	1999-05-11
MX9708662A (es)	1998-08-30

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