DZ558A1 - New thieno (3,2-c) pyridine derivatives, their preparation process and their therapeutic application. - Google Patents

New thieno (3,2-c) pyridine derivatives, their preparation process and their therapeutic application.

Info

Publication number
DZ558A1
DZ558A1 DZ836902A DZ836902A DZ558A1 DZ 558 A1 DZ558 A1 DZ 558A1 DZ 836902 A DZ836902 A DZ 836902A DZ 836902 A DZ836902 A DZ 836902A DZ 558 A1 DZ558 A1 DZ 558A1
Authority
DZ
Algeria
Prior art keywords
group
lower alkyl
pyridine derivatives
preparation process
image
Prior art date
Application number
DZ836902A
Other languages
French (fr)
Inventor
Daniel Aubert
Jean Pierre Maffrand
Claude Ferrand
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of DZ558A1 publication Critical patent/DZ558A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

This invention relates to new thieno [3,2-c] pyridine derivatives having the formula: <IMAGE> (I) in which: Y represents the OH group or an OR group in which R is a straight or branched lower alkyl radical, or Y represents a group <IMAGE> in which R1 and R2 are each independently of each other, hydrogen or a straight or branched lower alkyl group; or R1 and R2 form together and with the nitrogen atom to which they are attached a heterocycle which may include a second heteroatom such as oxygen or nitrogen, wherein the latter may be substituted by a lower alkyl or benzyl radical which may be substituted; and X represents hydrogen, a halogen or a lower alkyl radical; and their addition salts with pharmaceutically acceptable mineral or organic acids if Y represents the group OR or <IMAGE> or with mineral bases if Y represents OH, as well as the two enantiomers or their mixture. The invention also relates to the preparation process of new thieno [3,2-c] pyridine derivatives and to their therapeutic application as blood-platelet aggregation inhibiting agents and antithrombotics.
DZ836902A 1982-07-13 1983-07-11 New thieno (3,2-c) pyridine derivatives, their preparation process and their therapeutic application. DZ558A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8212599A FR2530247B1 (en) 1982-07-13 1982-07-13 NOVEL THIENO (3, 2-C) PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
DZ558A1 true DZ558A1 (en) 2004-09-13

Family

ID=9276096

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ836902A DZ558A1 (en) 1982-07-13 1983-07-11 New thieno (3,2-c) pyridine derivatives, their preparation process and their therapeutic application.

Country Status (33)

Country Link
US (1) US4529596A (en)
EP (1) EP0099802B1 (en)
JP (1) JPS5927895A (en)
KR (1) KR870001270B1 (en)
AT (1) ATE25384T1 (en)
AU (1) AU554358B2 (en)
CA (1) CA1194875A (en)
CS (1) CS246062B2 (en)
DD (1) DD211351A5 (en)
DE (1) DE3369683D1 (en)
DK (1) DK157552C (en)
DZ (1) DZ558A1 (en)
EG (1) EG16540A (en)
ES (1) ES523943A0 (en)
FI (1) FI73218C (en)
FR (1) FR2530247B1 (en)
GR (1) GR79592B (en)
HU (1) HU187111B (en)
IE (1) IE55895B1 (en)
IL (1) IL69049A (en)
MA (1) MA19843A1 (en)
MX (1) MX9203264A (en)
NO (1) NO159725C (en)
NZ (1) NZ204874A (en)
OA (1) OA07491A (en)
PH (1) PH19375A (en)
PL (1) PL142272B1 (en)
PT (1) PT77018B (en)
SG (1) SG95287G (en)
SU (1) SU1272994A3 (en)
UA (1) UA7142A1 (en)
YU (2) YU44384B (en)
ZA (1) ZA834705B (en)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8429087D0 (en) * 1984-11-16 1984-12-27 Scras Thienopyridine derivatives
FR2576901B1 (en) * 1985-01-31 1987-03-20 Sanofi Sa NOVEL DERIVATIVES OF A- (OXO-2 HEXAHYDRO-2,4,5,6,7,7A THIENO (3,2-C) PYRIDYL-5) ACETIC PHENYL, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR2596392B1 (en) * 1986-03-27 1988-08-05 Sanofi Sa DERIVATIVES OF ACID A- (HYDROXY-3 OXO-2 HEXAHYDRO-2,4,5,6,7,7A THIENO (3,2-C) PYRIDYL-5) PHENYLACETIC, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
FR2597102B1 (en) * 1986-04-14 1988-08-26 Sanofi Sa DERIVATIVES OF ACID A- (HYDROXY-7 TETRAHYDRO-4,5,6,7 THIENO (3,2-C) PYRIDYL-5) ACETIC PHENYL, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
FR2623810B2 (en) * 1987-02-17 1992-01-24 Sanofi Sa ALPHA SALTS- (TETRAHYDRO-4,5,6,7 THIENO (3,2-C) PYRIDYL-5) (2-CHLORO-PHENYL) -THETHYL ACETATE DEXTROGYRE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2612929B1 (en) * 1987-02-17 1990-02-09 Sanofi Sa DEXTROGYRE ENANTIOMER OF 1A- (TETRAHYDRO- 4,5,6,7 THIENO (3,2-C) PYRIDYL-5) (2-CHLORO-PHENYL) -METYL ACETATE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
FR2652575B1 (en) * 1989-09-29 1992-01-24 Sanofi Sa PROCESS FOR THE PREPARATION OF ALPHA-BROMO PHENYLACETIC ACIDS.
US5189170A (en) * 1989-09-29 1993-02-23 Sanofi Process for the preparation of phenylacetic derivatives of thieno-pyridines
FR2664596B1 (en) * 1990-07-10 1994-06-10 Sanofi Sa PROCESS FOR THE PREPARATION OF AN N-PHENYLACETIC DERIVATIVE OF TETRAHYDROTHIENO [3,2-C] PYRIDINE AND ITS SYNTHESIS INTERMEDIATE.
FR2672801B1 (en) * 1991-02-14 1995-03-03 Sanofi Sa USE OF TETRAHYDROTHIENOPYRIDINE DERIVATIVES AS INHIBITORS OF ANGIOGENESIS.
FI101150B (en) * 1991-09-09 1998-04-30 Sankyo Co Process for the preparation of tetrahydrothione nopyridine derivatives useful as a drug
NZ334389A (en) * 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
HU225503B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
HU222283B1 (en) 1997-05-13 2003-05-28 Sanofi-Synthelabo Novel process for producing thieno[3,2-c]pyridine derivatives
FR2769313B1 (en) * 1997-10-06 2000-04-21 Sanofi Sa DERIVATIVES OF HYDROXYACETIC ESTERS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS SYNTHESIS INTERMEDIATES
ID25589A (en) 1998-02-27 2000-10-19 Sankyo Company Ltd Cs AMINO CYCLE COMPOUNDS
WO1999065500A1 (en) 1998-06-17 1999-12-23 Bristol-Myers Squibb Company Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination
HU226421B1 (en) * 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
CA2367373C (en) 1999-03-17 2011-09-20 Daiichi Pharmaceutical Co., Ltd. Medicinal compositions
PL206138B1 (en) * 2000-12-25 2010-07-30 Daiichi Sankyo Company Limiteddaiichi Sankyo Company Limited Medicinal compositions containing aspirin
IN191030B (en) 2001-01-24 2003-09-13 Cadila Healthcare Ltd
EP1353928B1 (en) * 2001-01-24 2006-12-27 Cadila Healthcare Ltd. Process for preparing clopidogrel
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
CA2352520C (en) * 2001-07-06 2007-10-02 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
ITMI20020933A1 (en) * 2002-05-03 2003-11-03 Danimite Dipharma S P A CLOPIDOGREL SYNTHESIS PROCEDURE
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
AU2003270861A1 (en) * 2002-10-02 2004-04-23 Bristol-Myers Squibb Company Novel combination of a factor xa inhibitor and clopidogrel
US6812363B2 (en) * 2002-10-15 2004-11-02 Usv Limited Racemization of optically active 2-substituted phenyl glycine esters
ITMI20022228A1 (en) * 2002-10-21 2004-04-22 Dinamite Dipharma S P A CLOPIDOGREL SALTS WITH ALCHYL-SULPHURIC ACIDS.
WO2004074215A1 (en) * 2003-02-03 2004-09-02 Sunil Sadanand Nadkarni Process for preparation of clopidogrel, its salts and pharmaceutical compositions
DE10305984A1 (en) * 2003-02-13 2004-09-02 Helm Ag Salts of organic acids with clopidogrel and their use in the manufacture of pharmaceutical formulations
AU2003238664A1 (en) 2003-03-12 2004-09-30 Cadila Healthcare Limited Polymorphs and amorphous form of (s) - (+) -clopidogrel bisulfate
US6858734B2 (en) 2003-04-23 2005-02-22 Rhodia Pharma Solutions Inc. Preparation of (S)-Clopidogrel and related compounds
EP1618111B1 (en) 2003-04-25 2014-12-24 Cadila Healthcare Limited Salts of clopidogrel and process for preparation
DE10337773A1 (en) * 2003-08-13 2005-03-24 Krka Tovarna Zdravil, D.D. Crystallization of solid forms of clopidogrel addition salts
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
PL1680430T3 (en) 2003-11-03 2010-06-30 Cadila Healthcare Ltd Processes for preparing form i of (s)-(+)- clopidogrel bisulfate
CA2454015C (en) * 2003-12-23 2009-11-24 Brantford Chemicals Inc. A process for the preparation of tetrahydrothieno [3,2-c] pyridine derivatives
CA2457459A1 (en) * 2004-02-11 2005-08-11 Brantford Chemicals Inc. Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
EP1750701A1 (en) * 2004-06-01 2007-02-14 IVAX Pharmaceuticals s.r.o. Amorphous clopidogrel hydrochloride and its antithrombotic use
PE20060594A1 (en) * 2004-09-09 2006-08-18 Novartis Ag PHARMACEUTICAL COMPOSITION CONTAINING A PPAR AGONIST
KR20070052780A (en) * 2004-09-21 2007-05-22 테바 파마슈티컬 인더스트리즈 리미티드 Crystalline clopidogrel bromate and preparation method thereof
EP1851231A2 (en) * 2005-02-24 2007-11-07 Teva Pharmaceutical Industries Ltd Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
CZ299213B6 (en) 2005-03-08 2008-05-21 Zentiva, A. S Racemization process of methyl ester R(-)isomer of (2-chlorophenyl)-6,7 ûdihydro-thieno[3,2-c]pyridine-5(4H)-acetic acid
WO2006130852A1 (en) * 2005-06-02 2006-12-07 Dr. Reddy's Laboratories Ltd. Recovery of clopidogrel bisulfate
US8063217B2 (en) * 2005-07-12 2011-11-22 Rpg Life Sciences Limited Process for preparation of methyl-(+)-(S)-alpha-(2-chlorophenyl)-6, 7-dihydrothieno[3,2-C]pyridine-5(4H) -acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
WO2007029080A1 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Preparation of form i of clopidogrel hydrochloride
WO2007029096A2 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Novel polymorphic forms of clopidogrel hydrochloride
ES2391410T3 (en) * 2005-09-05 2012-11-26 Cadila Healthcare Limited Procedures for the preparation of different forms of (s) - (+) - clopidogrel besylate
CN100390180C (en) * 2005-12-15 2008-05-28 上海应用技术学院 Preparation method of clopidogrel and salt thereof
KR101235117B1 (en) * 2005-12-26 2013-02-20 에스케이케미칼주식회사 Process for the preparation of S-(+)-clopidogrel by optical resolution
KR100742134B1 (en) * 2006-02-07 2007-07-24 경동제약 주식회사 Crystalline S-(+)-methyl-2- (2-chlorophenyl) -2- (6,7-dihydrothieno [3,2-c] pyridin-5 (4H) -yl) acetate campylate Pharmaceutical composition comprising
HUE040311T2 (en) 2006-04-04 2019-02-28 Kg Acquisition Llc Oral dosage forms including an antiplatelet agent and an acid inhibitor
US20090099363A1 (en) * 2006-04-27 2009-04-16 Saxena Rahul Process for the preparation of polymorphic forms of clopidogrel hydrogen sulfate
EP2064217B1 (en) * 2006-09-04 2011-01-19 Ranbaxy Laboratories Limited An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts
EP1900358A1 (en) 2006-09-16 2008-03-19 Cimex Pharma AG Pharmaceutical formulations comprising clopidogrel
WO2008060934A2 (en) * 2006-11-14 2008-05-22 Acusphere, Inc. Formulations of tetrahydropyridine antiplatelet agents for parenteral or oral administration
EP1980563A1 (en) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
KR20090086903A (en) * 2007-04-18 2009-08-14 테바 파마슈티컬 인더스트리즈 리미티드 Improved Method of Making Clopidogrel
US8343995B2 (en) 2007-04-27 2013-01-01 Cydex Pharmaceuticals, Inc. Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
WO2008146249A1 (en) * 2007-05-30 2008-12-04 Wockhardt Research Centre Processes for the preparation of clopidogrel
WO2009080469A1 (en) * 2007-12-24 2009-07-02 Sandoz Ag Process for the preparation of clopidogrel bisulphate form i
EP2095815B1 (en) * 2008-02-26 2011-10-26 Laboratorios Lesvi, S.L. Pharmaceutical formulations containing clopidogrel
CN101983056A (en) * 2008-04-01 2011-03-02 安斯泰来制药有限公司 Preventive and/or therapeutic agent for vascular disease
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
US20090264460A1 (en) * 2008-04-21 2009-10-22 Mamta Mishra Clopidogrel pharmaceutical formulations
US20130303477A1 (en) * 2008-05-13 2013-11-14 The Medicines Company Maintenance of Platelet Inhibition During Antiplatelet Therapy
US20120141468A1 (en) * 2008-05-13 2012-06-07 Lisa Ruderman Chen Maintenance of platelet inhibition during antiplatelet therapy
US8759316B2 (en) * 2008-05-13 2014-06-24 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
WO2009140092A1 (en) 2008-05-13 2009-11-19 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US9427448B2 (en) 2009-11-11 2016-08-30 The Medicines Company Methods of treating, reducing the incidence of, and/or preventing ischemic events
KR100990949B1 (en) * 2008-06-09 2010-10-29 엔자이텍 주식회사 Method for preparing clopidogrel and its derivatives
US8299097B2 (en) * 2008-09-12 2012-10-30 The Brigham And Women's Hospital, Inc. Methods for treating inflammatory disorders
WO2010046476A1 (en) * 2008-10-24 2010-04-29 Sandoz Ag A process for the preparation of s-clopidogrel
US8563690B2 (en) * 2008-11-03 2013-10-22 The Board Of Trustees Of The University Of Illinois Modulation of platelet aggregation
CN101402641B (en) * 2008-11-20 2011-05-04 天津药物研究院 Oxime derivatives containing thienopyridine, preparation method and application thereof
EP2416799B1 (en) 2009-04-10 2017-11-01 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
CN102625658B (en) 2009-05-13 2015-01-28 锡德克斯药物公司 Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
EA021588B1 (en) 2009-06-25 2015-07-30 Тетра Сиа Betain salts of acetylsalicylic acid
CN101585842B (en) * 2009-07-13 2011-07-20 北京赛科药业有限责任公司 Research and control method of impurity B control method in clopidogrel
BR112012011298B1 (en) 2009-11-11 2021-12-14 Chiesi Farmaceutici S.P.A. USE OF CANGRELOR AND/OR BIVALIRUDIN IN DRUG PREPARATION AND DRUG COMBINATION
US10376532B2 (en) 2009-11-11 2019-08-13 Chiesi Farmaceutici, S.P.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
WO2011101865A2 (en) 2010-02-19 2011-08-25 Cadila Healthcare Limited Stable pharmaceutical compositions of clopidogrel for parenteral delivery
CN102212069A (en) * 2010-04-06 2011-10-12 刘桂坤 Naphthene derivatives and their preparation methods and their application in cardiovascular and cerebrovascular disease drugs
CN101812071A (en) * 2010-05-10 2010-08-25 杭州和素化学技术有限公司 Method for processing mother liquor obtained by splitting clopidogrel hydrogen sulfate intermediate
CN102241690B (en) 2010-05-13 2015-08-12 天津药物研究院 Thienopyridine ester derivative, the Preparation Method And The Use of one class nitrile group-containing
CN101863901B (en) * 2010-06-29 2012-12-05 天津药物研究院 2-(substituted phenyl)-2-(4,5,6,7-thiophane[3,2-c] pyridine-5(4H)-group)-N-substitute-acetamide as well as preparation method and application thereof
WO2012007019A1 (en) 2010-07-13 2012-01-19 Pharmathen S.A. Process for the preparation of clopidogrel and salts thereof
BR112013004165B1 (en) 2010-08-26 2021-07-20 Ipca Laboratories Limited COMPOSITION FOR THE TREATMENT OR PROPHYLAXIS OF THROMBOSIS OR EMBOLISM
CN101974015B (en) * 2010-10-11 2012-05-09 天津药物研究院 Ester compound, preparation method and application thereof
CN101962388B (en) * 2010-10-14 2012-12-19 天津药物研究院 Acetamide derivatives, preparation method and application thereof
CN101974016A (en) * 2010-10-14 2011-02-16 天津药物研究院 Amide compound and preparation method and applications thereof
CN106167483B (en) 2010-10-18 2019-02-15 塞伦尼斯医疗控股有限公司 It can be used for compound, composition and the method for cholesterol mobilization
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
AU2012277327B2 (en) 2011-06-27 2017-04-27 Ipca Laboratories Limited Anti-thrombotic compounds
US9539246B2 (en) 2011-08-30 2017-01-10 University Of Utah Research Foundation Methods and compositions for treating nephrogenic diabetes insipidus
WO2013084089A1 (en) 2011-12-09 2013-06-13 Wockhardt Limited Methods for treating cardiovascular disorder
CN103665042B (en) * 2012-09-21 2016-03-16 北京普禄德医药科技有限公司 Optically active 2-hydroxy tetrahydro thienopyridine derivative and its production and use
CN102993210A (en) * 2012-12-19 2013-03-27 苏春华 New thienopyridine compound
WO2014118802A1 (en) 2013-01-31 2014-08-07 Pharmazell Gmbh An improved process for the preparation of clopidogrel bisulfate form-i
CN104447867B (en) * 2013-09-17 2017-12-26 江苏天士力帝益药业有限公司 A kind of thieno piperidine derivative, preparation method and applications
DE102014108210A1 (en) * 2014-06-11 2015-12-17 Dietrich Gulba rodenticide
HUP1400294A2 (en) 2014-06-13 2015-12-28 Skillpharm Kft Novel application of clopidogrel
CN107698620A (en) 2015-06-23 2018-02-16 江苏天士力帝益药业有限公司 A kind of deuterated thieno piperidine derivative, preparation method and applications
WO2018234565A1 (en) 2017-06-23 2018-12-27 Chiesi Farmaceutici S.P.A. Method of preventing of systemic-to-pulmonary-artery shunt thrombosis
EP4070658A1 (en) 2021-04-06 2022-10-12 BIORoxx GmbH Use of anticoagulant active compounds as rodenticide
US20230059869A1 (en) 2021-08-03 2023-02-23 Liqmeds Worldwide Limited Oral pharmaceutical solution of clopidogrel
CN115260086A (en) * 2022-09-28 2022-11-01 吉林大学 Fluoro internal standard substance and application and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2527574A (en) * 1948-06-01 1950-10-31 Parke Davis & Co Esters of phenyl-heterocyclicaminoacetic acid and their production
FR1312412A (en) * 1959-12-18 1962-12-21 Dausse Lab Alpha-phenyl alpha-piperidino acetic acid derivatives and their preparation
FR2215948B1 (en) * 1973-02-01 1976-05-14 Centre Etd Ind Pharma

Also Published As

Publication number Publication date
FI73218B (en) 1987-05-29
PL242965A1 (en) 1984-07-16
PH19375A (en) 1986-04-02
DD211351A5 (en) 1984-07-11
DE3369683D1 (en) 1987-03-12
IL69049A (en) 1986-03-31
FI832543A0 (en) 1983-07-12
EG16540A (en) 1990-12-30
DK304183D0 (en) 1983-07-01
DK304183A (en) 1984-01-14
FR2530247A1 (en) 1984-01-20
PT77018B (en) 1986-01-24
YU197485A (en) 1986-10-31
CS528183A2 (en) 1985-12-16
EP0099802B1 (en) 1987-02-04
IL69049A0 (en) 1983-10-31
KR840005448A (en) 1984-11-12
EP0099802A1 (en) 1984-02-01
DK157552B (en) 1990-01-22
KR870001270B1 (en) 1987-06-30
NO159725B (en) 1988-10-24
NO159725C (en) 1989-02-01
ES8403901A1 (en) 1984-04-01
YU150683A (en) 1986-04-30
FI73218C (en) 1987-09-10
ES523943A0 (en) 1984-04-01
AU554358B2 (en) 1986-08-21
AU1663783A (en) 1984-01-19
IE831604L (en) 1984-01-13
US4529596A (en) 1985-07-16
YU45291B (en) 1992-05-28
PT77018A (en) 1983-08-01
OA07491A (en) 1985-03-31
FR2530247B1 (en) 1986-05-16
YU44384B (en) 1990-06-30
NO832530L (en) 1984-01-16
GR79592B (en) 1984-10-31
ATE25384T1 (en) 1987-02-15
ZA834705B (en) 1984-03-28
PL142272B1 (en) 1987-10-31
NZ204874A (en) 1986-01-24
JPS64955B2 (en) 1989-01-10
IE55895B1 (en) 1991-02-14
SG95287G (en) 1990-11-23
MX9203264A (en) 1992-07-01
MA19843A1 (en) 1984-04-01
SU1272994A3 (en) 1986-11-23
HU187111B (en) 1985-11-28
CA1194875A (en) 1985-10-08
DK157552C (en) 1990-06-11
UA7142A1 (en) 1995-06-30
CS246062B2 (en) 1986-10-16
JPS5927895A (en) 1984-02-14
FI832543L (en) 1984-01-14

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