EA036091B1 - ВОДНЫЕ СОСТАВЫ АНТИДОТОВ ФАКТОРА Xa (fXa) ДЛЯ ПРЕДУПРЕЖДЕНИЯ ИЛИ УМЕНЬШЕНИЯ КРОВОТЕЧЕНИЯ И ИХ ПРИМЕНЕНИЕ - Google Patents

ВОДНЫЕ СОСТАВЫ АНТИДОТОВ ФАКТОРА Xa (fXa) ДЛЯ ПРЕДУПРЕЖДЕНИЯ ИЛИ УМЕНЬШЕНИЯ КРОВОТЕЧЕНИЯ И ИХ ПРИМЕНЕНИЕ Download PDF

Info

Publication number: EA036091B1
Authority: EA; Eurasian Patent Office
Prior art keywords: seq; arginine; mannitol; sucrose; composition
Prior art date: 2014-08-20

Application number

EA201790415A

Other languages

English (en)

Russian (ru)

Other versions

EA201790415A1 (ru

Inventor

Дзуан Вонг

Грегори А. Сача

Фуонг М. Нгуйен

Original Assignee

Портола Фармасьютикалз, Инк.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-08-20

Filing date

2015-08-20

Publication date

2020-09-25

2015-08-20 Application filed by Портола Фармасьютикалз, Инк. filed Critical Портола Фармасьютикалз, Инк.

2017-08-31 Publication of EA201790415A1 publication Critical patent/EA201790415A1/ru

2020-09-25 Publication of EA036091B1 publication Critical patent/EA036091B1/ru

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Classifications

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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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EA201790415A 2014-08-20 2015-08-20 ВОДНЫЕ СОСТАВЫ АНТИДОТОВ ФАКТОРА Xa (fXa) ДЛЯ ПРЕДУПРЕЖДЕНИЯ ИЛИ УМЕНЬШЕНИЯ КРОВОТЕЧЕНИЯ И ИХ ПРИМЕНЕНИЕ EA036091B1 (ru)

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US201462039809P	2014-08-20	2014-08-20
PCT/US2015/046173 WO2016029061A1 (en)	2014-08-20	2015-08-20	Lyophilized formulations for factor xa antidote

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EA201790415A1 EA201790415A1 (ru)	2017-08-31
EA036091B1 true EA036091B1 (ru)	2020-09-25

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EA201790415A EA036091B1 (ru)	2014-08-20	2015-08-20	ВОДНЫЕ СОСТАВЫ АНТИДОТОВ ФАКТОРА Xa (fXa) ДЛЯ ПРЕДУПРЕЖДЕНИЯ ИЛИ УМЕНЬШЕНИЯ КРОВОТЕЧЕНИЯ И ИХ ПРИМЕНЕНИЕ
EA202091385A EA202091385A3 (ru)	2014-08-20	2015-08-20	Лиофилизированные составы для антидота фактора ха

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US (6)	US20160237420A1 (2)
EP (2)	EP3750556A1 (2)
JP (4)	JP6742986B2 (2)
KR (3)	KR102867491B1 (2)
CN (2)	CN113171447B (2)
AU (3)	AU2015305413B2 (2)
CA (1)	CA2961739C (2)
DK (1)	DK3182993T3 (2)
EA (2)	EA036091B1 (2)
ES (1)	ES2814157T3 (2)
IL (2)	IL250413B (2)
SG (1)	SG11201701247RA (2)
WO (1)	WO2016029061A1 (2)
ZA (1)	ZA201701764B (2)

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WO2017147522A1 (en) *	2016-02-24	2017-08-31	Portola Pharmaceuticals, Inc.	Lyophilized formulations for factor xa antidote
PT3472314T (pt) *	2016-06-17	2021-06-18	Alexion Pharma Inc	Preparação de derivados do fator xa
WO2018213151A1 (en) *	2017-05-18	2018-11-22	Merck Sharp & Dohme Corp.	Pharmaceutical formulation comprising incretin-insulin conjugates
CN112512480B (zh) *	2018-05-21	2024-10-01	中外制药株式会社	被封入玻璃容器的冷冻干燥制剂
CN110760479A (zh) *	2019-05-17	2020-02-07	上海交通大学医学院附属瑞金医院	靶向血小板表达的凝血因子Xa及其应用

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2015
- 2015-08-20 EP EP20170763.5A patent/EP3750556A1/en active Pending
- 2015-08-20 KR KR1020227045749A patent/KR102867491B1/ko active Active
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- 2015-08-20 WO PCT/US2015/046173 patent/WO2016029061A1/en not_active Ceased
- 2015-08-20 CN CN201580048166.3A patent/CN107073082B/zh active Active
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- 2015-08-20 AU AU2015305413A patent/AU2015305413B2/en active Active
2016
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2017
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2019
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2020
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2023
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2024
- 2024-09-13 AU AU2024219698A patent/AU2024219698A1/en active Pending
- 2024-11-05 US US18/937,646 patent/US20250163399A1/en active Pending

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AU2015305413B2 (en)	2020-09-24
KR102867491B1 (ko)	2025-10-01
JP6742986B2 (ja)	2020-08-19
JP2017525704A (ja)	2017-09-07
KR102482517B1 (ko)	2022-12-28
US20180320160A1 (en)	2018-11-08
KR20250150675A (ko)	2025-10-20
DK3182993T3 (da)	2020-09-21
JP2023158199A (ja)	2023-10-26
CN107073082A (zh)	2017-08-18
US20200299668A1 (en)	2020-09-24
AU2020289768B2 (en)	2024-06-13
IL250413B (en)	2020-09-30
US20210284986A1 (en)	2021-09-16
EP3750556A1 (en)	2020-12-16
KR20230007550A (ko)	2023-01-12
JP7416549B2 (ja)	2024-01-17
CN107073082B (zh)	2021-04-30
WO2016029061A1 (en)	2016-02-25
EA202091385A3 (ru)	2021-06-30
KR20170042776A (ko)	2017-04-19
AU2020289768A1 (en)	2021-01-21
JP2019206595A (ja)	2019-12-05
EA202091385A2 (ru)	2021-03-31
CN113171447B (zh)	2024-05-17
IL276960A (en)	2020-10-29
CA2961739C (en)	2024-04-30
IL276960B (en)	2022-04-01
CA2961739A1 (en)	2016-02-25
IL250413A0 (en)	2017-03-30
AU2015305413A1 (en)	2017-03-23
ZA201701764B (en)	2020-10-28
SG11201701247RA (en)	2017-03-30
JP2022003101A (ja)	2022-01-11
AU2024219698A1 (en)	2024-10-03
US20160237420A1 (en)	2016-08-18
EP3182993A4 (en)	2018-01-17
ES2814157T3 (es)	2021-03-26
EP3182993A1 (en)	2017-06-28
US11028382B2 (en)	2021-06-08
CN113171447A (zh)	2021-07-27
EP3182993B1 (en)	2020-07-01
EA201790415A1 (ru)	2017-08-31
US20200299667A1 (en)	2020-09-24
US20250163399A1 (en)	2025-05-22

Publication	Publication Date	Title
US20250163399A1 (en)	2025-05-22	Lyophilized formulations for factor xa antidote
WO2010149907A1 (fr)	2010-12-29	Composition de facteur vii
US12005144B2 (en)	2024-06-11	Lyophilized formulations for factor XA antidote
HK40042818A (en)	2021-09-03	Lyophilized formulations for factor xa antidote
EA048314B1 (ru)	2024-11-19	Лиофилизированные составы для антидота фактора ха
HK40001910B (en)	2022-03-11	Lyophilized formulations for factor xa antidote