EA200000672A1 - Кристалический терипаратид - Google Patents

Кристалический терипаратид

Info

Publication number
EA200000672A1
EA200000672A1 EA200000672A EA200000672A EA200000672A1 EA 200000672 A1 EA200000672 A1 EA 200000672A1 EA 200000672 A EA200000672 A EA 200000672A EA 200000672 A EA200000672 A EA 200000672A EA 200000672 A1 EA200000672 A1 EA 200000672A1
Authority
EA
Eurasian Patent Office
Prior art keywords
teriparatide
crystal
purification
preparation
methods
Prior art date
Application number
EA200000672A
Other languages
English (en)
Inventor
Фэминг Занг
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200000672A1 publication Critical patent/EA200000672A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)

Abstract

(57) Описаны очищенный стабильный паратиреоидный гормон, в частности терипаратид, в кристаллическом состоянии, а также способы его получения и очистки.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000672A 1997-12-18 1998-12-08 Кристалический терипаратид EA200000672A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6987597P 1997-12-18 1997-12-18
PCT/US1998/026044 WO1999031137A1 (en) 1997-12-18 1998-12-08 Crystalline teriparatide

Publications (1)

Publication Number Publication Date
EA200000672A1 true EA200000672A1 (ru) 2000-12-25

Family

ID=22091750

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000672A EA200000672A1 (ru) 1997-12-18 1998-12-08 Кристалический терипаратид

Country Status (24)

Country Link
US (1) US6590081B1 (ru)
EP (1) EP0926158B1 (ru)
JP (1) JP2002508395A (ru)
KR (1) KR20010033268A (ru)
CN (1) CN1281467A (ru)
AR (1) AR038648A1 (ru)
AT (1) ATE245165T1 (ru)
AU (1) AU748271B2 (ru)
BR (1) BR9813740A (ru)
CA (1) CA2315103A1 (ru)
DE (1) DE69816409T2 (ru)
DK (1) DK0926158T3 (ru)
EA (1) EA200000672A1 (ru)
ES (1) ES2202729T3 (ru)
HU (1) HUP0100075A2 (ru)
ID (1) ID25660A (ru)
IL (1) IL136824A0 (ru)
NO (1) NO20003131D0 (ru)
PE (1) PE20000056A1 (ru)
PL (1) PL341209A1 (ru)
PT (1) PT926158E (ru)
TR (1) TR200002179T2 (ru)
WO (1) WO1999031137A1 (ru)
ZA (1) ZA9811407B (ru)

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US7601685B2 (en) 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
ES2301697T3 (es) * 2001-12-18 2008-07-01 Eidgenossisch Technische Hochschule Zurich Matrices de proteina modificada con factor de crecimiento para ingenieria de tejidos.
EP1864681A1 (en) 2001-12-18 2007-12-12 Eidgenössische Technische Hochschule Zürich Growth factor modified protein matrices for tissue engineering
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
AU2003278766A1 (en) * 2002-09-04 2004-03-29 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
CA2512052C (en) 2002-12-31 2016-06-21 Altus Pharmaceuticals Inc. Human growth hormone crystals and methods for preparing them
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
US7553827B2 (en) * 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
US20040229878A1 (en) * 2003-05-13 2004-11-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of P38 kinase
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
US7344716B2 (en) * 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US7429378B2 (en) * 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US8361467B2 (en) * 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
US8895540B2 (en) * 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
CN101151048A (zh) * 2004-05-10 2008-03-26 纳斯泰克制药公司 增强甲状旁腺激素粘膜递送的组合物和方法
US20060127320A1 (en) * 2004-05-10 2006-06-15 Nastech Pharmaceutical Company Inc. Method of delivering parathyroid hormone to a human
US20060052305A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. Method of treating osteoporosis using intranasal parathyroid hormone
JP5007427B2 (ja) 2004-05-13 2012-08-22 アルザ コーポレイション 副甲状腺ホルモン剤の経皮送達のための装置および方法
WO2006073711A2 (en) 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
CA2595457A1 (en) 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments
US7691105B2 (en) 2005-09-26 2010-04-06 Depuy Spine, Inc. Tissue augmentation, stabilization and regeneration technique
US20070088436A1 (en) 2005-09-29 2007-04-19 Matthew Parsons Methods and devices for stenting or tamping a fractured vertebral body
US20070173447A1 (en) * 2005-10-25 2007-07-26 Nastech Pharmaceutical Company Inc. Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent
BRPI0618469A2 (pt) * 2005-11-10 2011-08-30 Univ Michigan Tech hormÈnio paratiróide de urso preto e métodos de uso de hormÈnio paratiróide de urso preto
US20080051332A1 (en) * 2005-11-18 2008-02-28 Nastech Pharmaceutical Company Inc. Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone
US20070168041A1 (en) * 2006-01-17 2007-07-19 Sudhakar Kadiyala Method and instruments for intervertebral disc augmentation through a pedicular approach
EP2136850B1 (en) 2007-04-13 2012-02-01 Kuros Biosurgery AG Polymeric tissue sealant
CA2694562A1 (en) * 2007-08-09 2009-02-12 Usv Limited Novel orthogonal process for purification of recombinant human parathyroid hormone (rhpth) (1-34)
AR066166A1 (es) * 2007-09-21 2009-07-29 Organon Nv Sistema de suministro de droga
US8241294B2 (en) 2007-12-19 2012-08-14 Depuy Spine, Inc. Instruments for expandable corpectomy spinal fusion cage
US8241363B2 (en) 2007-12-19 2012-08-14 Depuy Spine, Inc. Expandable corpectomy spinal fusion cage
US20090162351A1 (en) * 2007-12-21 2009-06-25 Depuy Spine, Inc. Transdiscal administration of inhibitors of p38 MAP kinase
US8986696B2 (en) * 2007-12-21 2015-03-24 Depuy Mitek, Inc. Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
JP2012512812A (ja) 2007-12-28 2012-06-07 クロス・バイオサージェリー・アクチェンゲゼルシャフト フィブリンフォームに組込まれたｐｄｇｆ融合タンパク質
US8876905B2 (en) 2009-04-29 2014-11-04 DePuy Synthes Products, LLC Minimally invasive corpectomy cage and instrument
CA2782640A1 (en) 2009-12-07 2011-06-16 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US8865220B2 (en) 2010-06-14 2014-10-21 Kaohsiung Medical University Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres
WO2012123028A1 (en) 2011-03-16 2012-09-20 Kuros Biosurgery Ag Pharmaceutical formulation for use in spinal fusion
CN102731643A (zh) * 2012-06-26 2012-10-17 深圳翰宇药业股份有限公司 一种治疗骨质疏松多肽的制备方法
US10413504B2 (en) 2013-12-11 2019-09-17 Merck Sharp & Dohme Corp. Intravaginal ring drug delivery system
US10596103B2 (en) 2013-12-11 2020-03-24 Merek Sharp & Dohme B.V. Drug delivery system for delivery of anti-virals
CN104910269B (zh) * 2015-06-02 2018-08-17 成都圣诺生物科技股份有限公司 一种合成特立帕肽的方法
US20200289621A1 (en) * 2017-09-22 2020-09-17 Asahi Kasei Pharma Corporation Teriparatide-containing liquid pharmaceutical composition having excellent stability

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62106000A (ja) * 1985-10-30 1987-05-16 Fujitsu Ltd 生体高分子結晶自動作製装置
DE3855331T2 (de) * 1987-10-20 1996-10-24 Michael F Holick Regulierung der zellenproliferation und differenzierung mittels peptiden
JPH07500806A (ja) * 1991-10-09 1995-01-26 シェリング・コーポレーション 結晶形成装置及び自動化された結晶化装置
US5400741A (en) 1993-05-21 1995-03-28 Medical Foundation Of Buffalo, Inc. Device for growing crystals
US5496801A (en) * 1993-12-23 1996-03-05 Allelix Biopharmaceuticals Inc. Parathyroid hormone formulation
US5419278A (en) 1994-05-25 1995-05-30 Carter; Daniel C. Vapor equilibration tray for growing protein crystals
CA2178894A1 (en) 1995-06-15 1996-12-16 Tsunehiko Fukuda Parathyroid hormone derivatives and their use

Also Published As

Publication number Publication date
TR200002179T2 (tr) 2001-07-23
PT926158E (pt) 2003-11-28
PE20000056A1 (es) 2000-02-08
HUP0100075A2 (hu) 2001-05-28
AR038648A1 (es) 2005-01-26
DE69816409T2 (de) 2004-06-09
PL341209A1 (en) 2001-03-26
KR20010033268A (ko) 2001-04-25
CA2315103A1 (en) 1999-06-24
EP0926158A1 (en) 1999-06-30
JP2002508395A (ja) 2002-03-19
NO20003131L (no) 2000-06-16
ATE245165T1 (de) 2003-08-15
ES2202729T3 (es) 2004-04-01
CN1281467A (zh) 2001-01-24
AU748271B2 (en) 2002-05-30
US6590081B1 (en) 2003-07-08
DK0926158T3 (da) 2003-11-10
WO1999031137A1 (en) 1999-06-24
ID25660A (id) 2000-10-19
DE69816409D1 (de) 2003-08-21
ZA9811407B (en) 2000-07-13
AU1632699A (en) 1999-07-05
EP0926158B1 (en) 2003-07-16
BR9813740A (pt) 2000-10-10
IL136824A0 (en) 2001-06-14
NO20003131D0 (no) 2000-06-16

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