EA200000792A2 - Новые пиридиновые соединения, способ их получения и содержащие их фармацевтические композиции - Google Patents

Новые пиридиновые соединения, способ их получения и содержащие их фармацевтические композиции

Info

Publication number
EA200000792A2
EA200000792A2 EA200000792A EA200000792A EA200000792A2 EA 200000792 A2 EA200000792 A2 EA 200000792A2 EA 200000792 A EA200000792 A EA 200000792A EA 200000792 A EA200000792 A EA 200000792A EA 200000792 A2 EA200000792 A2 EA 200000792A2
Authority
EA
Eurasian Patent Office
Prior art keywords
group
preparation
pharmaceutical compositions
compositions containing
pyridine compounds
Prior art date
Application number
EA200000792A
Other languages
English (en)
Other versions
EA200000792A3 (ru
EA004102B1 (ru
Inventor
Жан-Луи Пеглион
Эме Дессанж
Кристоф Пуатевен
Марк Миллан
Анн Декейн
Original Assignee
Адир Э Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Адир Э Компани filed Critical Адир Э Компани
Publication of EA200000792A2 publication Critical patent/EA200000792A2/ru
Publication of EA200000792A3 publication Critical patent/EA200000792A3/ru
Publication of EA004102B1 publication Critical patent/EA004102B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Соединения формулы (I)где W представляет необязательно замещенную нафтильную группу или группу формулы Y (где Y), определенную в описании,n представляет целое число от 1 до 6 включительно,Z представляет одинарную связь, атом кислорода или необязательно замещенный атом азота,A и Q представляют каждый группу CH или атом азота,M, вместе с углеродными атомами фенильного кольца, к которым он присоединен, представляет тиенильную, фурильную, пирролильную или оксипирролильную группу,их изомеры; а также их аддитивные соли с фармацевтически приемлемой(ым) кислотой или основанием. Лекарственные средства.
EA200000792A 1999-08-27 2000-08-25 Пиридиновые соединения, способ их получения и содержащие их фармацевтические композиции EA004102B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9910834A FR2797874B1 (fr) 1999-08-27 1999-08-27 Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
EA200000792A2 true EA200000792A2 (ru) 2001-04-23
EA200000792A3 EA200000792A3 (ru) 2001-06-25
EA004102B1 EA004102B1 (ru) 2003-12-25

Family

ID=9549376

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000792A EA004102B1 (ru) 1999-08-27 2000-08-25 Пиридиновые соединения, способ их получения и содержащие их фармацевтические композиции

Country Status (22)

Country Link
US (2) US6399616B1 (ru)
EP (1) EP1078928B1 (ru)
JP (1) JP3602780B2 (ru)
KR (1) KR100450317B1 (ru)
CN (1) CN1163495C (ru)
AT (1) ATE266664T1 (ru)
AU (1) AU765661B2 (ru)
BR (1) BR0003848A (ru)
CA (1) CA2317053A1 (ru)
DE (1) DE60010596T2 (ru)
DK (1) DK1078928T3 (ru)
EA (1) EA004102B1 (ru)
ES (1) ES2220359T3 (ru)
FR (1) FR2797874B1 (ru)
HU (1) HUP0003413A3 (ru)
MX (1) MXPA00008241A (ru)
NO (1) NO316651B1 (ru)
NZ (1) NZ506560A (ru)
PL (1) PL342178A1 (ru)
PT (1) PT1078928E (ru)
SI (1) SI1078928T1 (ru)
ZA (1) ZA200004411B (ru)

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FR2797874B1 (fr) * 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE10031391A1 (de) * 2000-07-03 2002-02-07 Knoll Ag Bicyclische Verbindungen und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie
AU2002242996A1 (en) * 2001-03-29 2002-10-15 Tanabe Seiyaku Co., Ltd. Spiroisoquinoline compounds, methods for their preparation and intermediates
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
EP1572647B1 (en) * 2002-12-20 2016-09-21 Basf Se Synthesis of amines and intermediates for the synthesis thereof
JP4559749B2 (ja) * 2004-02-16 2010-10-13 あすか製薬株式会社 ピペラジニルピリジン誘導体
JP4596792B2 (ja) * 2004-02-24 2010-12-15 あすか製薬株式会社 ５−ｈｔ１ａ作動作用と５−ｈｔ３拮抗作用を併有する薬剤
WO2005082887A1 (ja) 2004-02-26 2005-09-09 Aska Pharmaceutical Co., Ltd. ピリミジン誘導体
DE102004023506A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023508A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Säurederivate substituierter Cyclohexyl-1,4-diamine
DE102004023501A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate
EP1773777A1 (en) * 2004-07-23 2007-04-18 Bayer Cropscience Sa N-[2-(4-pyridinyl)ethyl]benzamide derivatives as fungicides
ES2331144T3 (es) 2004-11-26 2009-12-22 Janssen Pharmaceutica Nv Derivados de isoxazolina-indol con actividad antipsicotica y ansiolitica mejorada.
FR2909670B1 (fr) * 2006-12-12 2010-07-30 Sanofi Aventis Derive fluore de quinoleine-2(1h)-one,son procede de preparation et son utilisation comme intermediaire de synthese
US9598401B2 (en) 2013-07-29 2017-03-21 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
CN105992766A (zh) * 2013-12-13 2016-10-05 武田药品工业株式会社 作为tlr抑制剂的吡咯并[3,2-c]吡啶衍生物
US9968604B2 (en) 2015-04-16 2018-05-15 Chiesi Farmaceutici S.P.A. Chromene derivatives as phoshoinositide 3-kinases inhibitors
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
CN106795160B (zh) * 2015-07-23 2019-04-19 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
AU2022237901A1 (en) * 2021-03-19 2023-09-28 Centre National De La Recherche Scientifique Applications of biased ligands of the serotonin 5-ht7 receptor for the treatment of pain, multiple sclerosis and the control of thermoregulation.

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FR2312498A1 (fr) * 1975-05-30 1976-12-24 Parcor Procede de preparation de la thieno (3,2-c) pyridine et de derives de celle-ci
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FR2797874B1 (fr) * 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
CN1163495C (zh) 2004-08-25
DK1078928T3 (da) 2004-09-13
EA200000792A3 (ru) 2001-06-25
MXPA00008241A (es) 2002-08-20
JP2001097978A (ja) 2001-04-10
KR20010050228A (ko) 2001-06-15
HK1034250A1 (en) 2001-10-19
JP3602780B2 (ja) 2004-12-15
ATE266664T1 (de) 2004-05-15
PT1078928E (pt) 2004-09-30
HU0003413D0 (en) 2000-08-25
FR2797874A1 (fr) 2001-03-02
FR2797874B1 (fr) 2002-03-29
EP1078928A1 (fr) 2001-02-28
US20020161228A1 (en) 2002-10-31
EP1078928B1 (fr) 2004-05-12
PL342178A1 (en) 2001-03-12
CA2317053A1 (fr) 2001-02-27
NO316651B1 (no) 2004-03-22
ZA200004411B (en) 2001-02-28
SI1078928T1 (en) 2004-08-31
BR0003848A (pt) 2001-04-03
DE60010596T2 (de) 2005-05-19
NO20004295L (no) 2001-02-28
DE60010596D1 (de) 2004-06-17
NO20004295D0 (no) 2000-08-28
NZ506560A (en) 2001-06-29
CN1286255A (zh) 2001-03-07
EA004102B1 (ru) 2003-12-25
AU765661B2 (en) 2003-09-25
AU5364200A (en) 2001-03-01
US6399616B1 (en) 2002-06-04
US6486171B2 (en) 2002-11-26
KR100450317B1 (ko) 2004-09-30
ES2220359T3 (es) 2004-12-16
HUP0003413A2 (hu) 2001-07-30
HUP0003413A3 (en) 2003-11-28

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