EA200200073A1 - Многодозовые эритропоэтиновые составы - Google Patents

Многодозовые эритропоэтиновые составы

Info

Publication number
EA200200073A1
EA200200073A1 EA200200073A EA200200073A EA200200073A1 EA 200200073 A1 EA200200073 A1 EA 200200073A1 EA 200200073 A EA200200073 A EA 200200073A EA 200200073 A EA200200073 A EA 200200073A EA 200200073 A1 EA200200073 A1 EA 200200073A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dose
erythropoethyn
compositions
formulations
phenoxyethanol
Prior art date
Application number
EA200200073A
Other languages
English (en)
Other versions
EA006220B1 (ru
Inventor
Атеф Гайед
Original Assignee
Авентис Фармасьютиклс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фармасьютиклс, Инк. filed Critical Авентис Фармасьютиклс, Инк.
Publication of EA200200073A1 publication Critical patent/EA200200073A1/ru
Publication of EA006220B1 publication Critical patent/EA006220B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к многодозовым эритропоэтиновым составам для парентерального применения. Составы содержат один или более следующих консервантов: бензетониума хлорид, феноксиэтанол и фенилэтиловый спирт.Отчет о международном поиске был опубликован 2001.10.04.
EA200200073A 1999-07-22 2000-07-21 Многодозовые эритропоэтиновые составы EA006220B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19821699P 1999-07-22 1999-07-22
PCT/US2000/040446 WO2001007075A2 (en) 1999-07-22 2000-07-21 Multi-dose erythropoietin formulations

Publications (2)

Publication Number Publication Date
EA200200073A1 true EA200200073A1 (ru) 2002-08-29
EA006220B1 EA006220B1 (ru) 2005-10-27

Family

ID=22732468

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200073A EA006220B1 (ru) 1999-07-22 2000-07-21 Многодозовые эритропоэтиновые составы

Country Status (25)

Country Link
US (1) US7432360B2 (ru)
EP (1) EP1200115B9 (ru)
JP (1) JP2003517462A (ru)
KR (1) KR100693263B1 (ru)
CN (2) CN101091792A (ru)
AT (1) ATE304863T1 (ru)
AU (1) AU777397B2 (ru)
BR (1) BR0012667A (ru)
CA (1) CA2378945C (ru)
CZ (1) CZ302750B6 (ru)
DE (1) DE60022759T2 (ru)
DK (1) DK1200115T3 (ru)
EA (1) EA006220B1 (ru)
EE (1) EE200200037A (ru)
ES (1) ES2248110T3 (ru)
HK (1) HK1050318A1 (ru)
HR (1) HRP20020159B1 (ru)
HU (1) HUP0202246A3 (ru)
IL (2) IL147755A0 (ru)
NO (1) NO20020303L (ru)
NZ (1) NZ516735A (ru)
PL (1) PL202945B1 (ru)
RS (1) RS50355B (ru)
WO (1) WO2001007075A2 (ru)
ZA (1) ZA200200742B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL147756A (en) 1999-07-22 2005-12-18 Aventis Pharma Inc Preserved pharmaceutical formulations
MEP90708A (hr) 2000-05-15 2011-12-20 Nova farmaceutska smješa
US7148211B2 (en) 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
CN1960745A (zh) * 2004-03-26 2007-05-09 詹森药业有限公司 促红细胞生成素组合加药方案
US7772182B2 (en) 2004-08-05 2010-08-10 Alza Corporation Stable suspension formulations of erythropoietin receptor agonists
EP1845934B1 (de) * 2005-02-03 2008-05-14 Clariant Produkte (Deutschland) GmbH Konservierungsmittel
JP2011116752A (ja) * 2009-10-29 2011-06-16 Jcr Pharmaceuticals Co Ltd エリスロポエチン含有水性液剤
KR101805087B1 (ko) * 2010-09-16 2017-12-05 주식회사 엘지화학 높은 방부력을 제공하는 오일 주사 제형
ES2982752T3 (es) * 2015-10-22 2024-10-17 Iltoo Pharma Composiciones farmacéuticas de il-2

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3489837A (en) * 1968-07-11 1970-01-13 Leroy J Hyman Synergistic antiseptic composition consisting of 9-aminoacridine hydrochloride and benzethonium chloride
JPS6045849B2 (ja) 1980-08-25 1985-10-12 林原 健 ヒトエリトロポエチンの製造方法
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
JPS6191131A (ja) * 1984-10-09 1986-05-09 Chugai Pharmaceut Co Ltd 医薬品の吸着防止方法および組成物
JPS6197229A (ja) 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
JPH0651637B2 (ja) * 1985-03-28 1994-07-06 エーザイ株式会社 ペプタイドの吸着防止組成物
US5045529A (en) * 1989-03-27 1991-09-03 Bionostics, Inc. Tonometric fluid for blood gas and co-oximetry instruments
JP3249147B2 (ja) * 1990-06-01 2002-01-21 キリン−アムジエン・インコーポレーテツド 生理活性蛋白含有経口製剤
CA2050425A1 (en) * 1990-09-03 1992-03-04 Yoshiaki Uda Pharmaceutical composition and its mucous use
DE4126983A1 (de) * 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
US5661125A (en) 1992-08-06 1997-08-26 Amgen, Inc. Stable and preserved erythropoietin compositions
JP2532025B2 (ja) * 1993-07-23 1996-09-11 株式会社林原生物化学研究所 新リンホカインｉｉｉを有効成分とする抗腫瘍作用を有するリンホカインの活性増強剤
WO1995033474A1 (en) * 1994-06-03 1995-12-14 Tsumura & Co. Medicinal composition
JP2000504319A (ja) * 1996-01-19 2000-04-11 イーライ・リリー・アンド・カンパニー 肥満症タンパク質製剤
WO1998010785A1 (en) * 1996-09-13 1998-03-19 Advanced Medicine Research Institute Ophthalmic compositions of neurotrophic factors, remedies for optic nerve function disorders and method for treating optic nerve function disorders
JPH1112193A (ja) * 1997-06-19 1999-01-19 Sankyo Co Ltd ヒトカルシトニン含有水溶液製剤
GB9726555D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Vaccine

Also Published As

Publication number Publication date
CA2378945C (en) 2010-02-23
NO20020303D0 (no) 2002-01-21
HRP20020159B1 (en) 2007-08-31
BR0012667A (pt) 2002-07-02
WO2001007075A3 (en) 2001-10-04
AU777397B2 (en) 2004-10-14
CA2378945A1 (en) 2001-02-01
DE60022759D1 (de) 2006-02-02
EP1200115B1 (en) 2005-09-21
NO20020303L (no) 2002-03-21
ATE304863T1 (de) 2005-10-15
IL147755A0 (en) 2002-08-14
AU7137400A (en) 2001-02-13
KR100693263B1 (ko) 2007-03-13
CZ2002264A3 (cs) 2002-06-12
EP1200115A2 (en) 2002-05-02
DE60022759T2 (de) 2006-06-22
HRP20020159A2 (en) 2003-06-30
PL353569A1 (en) 2003-12-01
EE200200037A (et) 2003-04-15
US20050267033A1 (en) 2005-12-01
RS50355B (sr) 2009-11-10
CZ302750B6 (cs) 2011-10-19
HK1050318A1 (zh) 2003-06-20
JP2003517462A (ja) 2003-05-27
YU4702A (sh) 2005-06-10
EP1200115B9 (en) 2006-01-18
HUP0202246A2 (en) 2002-10-28
CN101091792A (zh) 2007-12-26
ES2248110T3 (es) 2006-03-16
EA006220B1 (ru) 2005-10-27
DK1200115T3 (da) 2006-01-16
CN1371284A (zh) 2002-09-25
US7432360B2 (en) 2008-10-07
ZA200200742B (en) 2003-06-25
KR20020011143A (ko) 2002-02-07
PL202945B1 (pl) 2009-08-31
NZ516735A (en) 2004-01-30
HUP0202246A3 (en) 2010-01-28
IL147755A (en) 2009-11-18
WO2001007075A2 (en) 2001-02-01

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU