EA200401432A1 - Сложноэфирные производные декагидроизохинолин-3-карбоновой кислоты в качестве анальгетиков - Google Patents

Сложноэфирные производные декагидроизохинолин-3-карбоновой кислоты в качестве анальгетиков

Info

Publication number
EA200401432A1
EA200401432A1 EA200401432A EA200401432A EA200401432A1 EA 200401432 A1 EA200401432 A1 EA 200401432A1 EA 200401432 A EA200401432 A EA 200401432A EA 200401432 A EA200401432 A EA 200401432A EA 200401432 A1 EA200401432 A1 EA 200401432A1
Authority
EA
Eurasian Patent Office
Prior art keywords
difesticiative
decahydroisohinolin
analhetics
derivatives
formula
Prior art date
Application number
EA200401432A
Other languages
English (en)
Other versions
EA009526B1 (ru
Inventor
Пол Лесли Орнштейн
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200401432A1 publication Critical patent/EA200401432A1/ru
Publication of EA009526B1 publication Critical patent/EA009526B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение касается соединений формулы (I). Настоящее изобретение также касается применения соединения формулы (I) для изготовления лекарственного средства для лечения неврологических нарушений. Кроме того, настоящее изобретение касается применения соединения формулы (I) для изготовления лекарственного средства для лечения боли или мигрени.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401432A 2002-04-26 2003-04-14 Сложноэфирные производные декагидроизохинолин-3-карбоновой кислоты в качестве анальгетиков EA009526B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37612002P 2002-04-26 2002-04-26
PCT/US2003/010466 WO2003091243A1 (en) 2002-04-26 2003-04-14 Ester derivatives of a decahydroisoquinoline-3-carboxylic acid as analgestics

Publications (2)

Publication Number Publication Date
EA200401432A1 true EA200401432A1 (ru) 2005-04-28
EA009526B1 EA009526B1 (ru) 2008-02-28

Family

ID=29270765

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401432A EA009526B1 (ru) 2002-04-26 2003-04-14 Сложноэфирные производные декагидроизохинолин-3-карбоновой кислоты в качестве анальгетиков

Country Status (18)

Country Link
US (1) US7247644B2 (ru)
EP (1) EP1511741B1 (ru)
JP (2) JP2005529892A (ru)
KR (1) KR100757787B1 (ru)
CN (1) CN100436446C (ru)
AU (1) AU2003226277B2 (ru)
BR (1) BR0308911A (ru)
CA (1) CA2480026C (ru)
DK (1) DK1511741T3 (ru)
EA (1) EA009526B1 (ru)
ES (1) ES2398225T3 (ru)
IL (1) IL164773A (ru)
MX (1) MXPA04009857A (ru)
NZ (1) NZ535245A (ru)
PT (1) PT1511741E (ru)
SI (1) SI1511741T1 (ru)
WO (1) WO2003091243A1 (ru)
ZA (1) ZA200409552B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1511741T3 (da) * 2002-04-26 2013-01-21 Lilly Co Eli Esterderivater af en decahydroisoquinolin-3-carboxylsyre som analgetika
CA2686816A1 (en) 2007-01-16 2008-07-24 The Johns Hopkins University Use of various glutamate receptor antagonists for delaying or preventing platelet activity or for treating or preventing a thrombotic disease or disorder
AU2021299570A1 (en) * 2020-07-02 2023-02-23 Sea Pharmaceuticals Llc Pharmaceutical compositions of 6-(2-(2H-tetrazol-5-yl)ethyl)-6-fluorodecahydroisoquinoline-3-carboxylic acid and ester derivatives thereof
KR20240022544A (ko) * 2021-06-09 2024-02-20 프로니라스 코포레이션 신경 작용제-유도 발작을 치료하는 방법
WO2023130008A2 (en) * 2022-01-01 2023-07-06 Sea Pharmaceuticals Llc Pharmaceutical compositions of 6-(2-(2h-tetrazol-5-yl)ethyl)decahydroisoquinoline-3-carboxylic acid and derivatives thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK406686D0 (da) * 1986-08-26 1986-08-26 Hans Bundgaard Carboxylsyrederivater
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5284957A (en) 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5356902A (en) 1992-11-06 1994-10-18 Eli Lilly And Company Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists
US5446051A (en) 1994-05-31 1995-08-29 Eli Lilly And Company Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists
US5767117A (en) 1994-11-18 1998-06-16 The General Hospital Corporation Method for treating vascular headaches
WO1998045270A1 (en) 1997-04-07 1998-10-15 Eli Lilly And Company Pharmacological agents
ATE240299T1 (de) 1999-07-06 2003-05-15 Lilly Co Eli Diester prodrugs von decahydroischinoline-3- carbonsäure
CN1230174C (zh) 1999-07-06 2005-12-07 伊莱利利公司 治疗偏头痛的选择性iGluR5受体拮抗剂
EP1257545A1 (en) 1999-12-22 2002-11-20 Eli Lilly And Company SELECTIVE iGLUR 5? RECEPTOR ANTAGONISTS
US6953805B2 (en) 2001-01-05 2005-10-11 Eli Lilly And Company Excitatory amino acid receptor antagonists
MXPA03005982A (es) 2001-01-05 2003-09-10 Lilly Co Eli Antagonistas de receptores de aminoacidos excitadores.
AU2001298029A1 (en) 2001-01-05 2003-04-01 Eli Lilly And Company Derivatives of the (3s, 4ar, 6s, 8ar) 6-phenylamino-1, 2, 3, 4, 4a, 5, 6, 7, 8, 8a-decahydro isoquinoline-3-carboxylic acid as excitatory amino acid receptor antagonists for the treatment of neurological disorders and neurodegenerative diseases
US6855725B2 (en) 2001-01-05 2005-02-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
AU2003219955A1 (en) 2002-03-22 2003-10-13 Eli Lilly And Company Isoquinoline-3-carboxylic acid derivatives as excitatory amino acid receptor antagonists
DK1511741T3 (da) * 2002-04-26 2013-01-21 Lilly Co Eli Esterderivater af en decahydroisoquinolin-3-carboxylsyre som analgetika

Also Published As

Publication number Publication date
BR0308911A (pt) 2005-01-04
DK1511741T3 (da) 2013-01-21
PT1511741E (pt) 2013-02-05
KR20040102171A (ko) 2004-12-03
WO2003091243A8 (en) 2005-03-31
EP1511741B1 (en) 2012-12-26
MXPA04009857A (es) 2004-12-07
AU2003226277A1 (en) 2003-11-10
JP2010235623A (ja) 2010-10-21
EP1511741A1 (en) 2005-03-09
AU2003226277B2 (en) 2009-03-26
IL164773A (en) 2011-08-31
KR100757787B1 (ko) 2007-09-11
CA2480026C (en) 2011-06-07
NZ535245A (en) 2007-11-30
US20050256155A1 (en) 2005-11-17
EA009526B1 (ru) 2008-02-28
WO2003091243A1 (en) 2003-11-06
ES2398225T3 (es) 2013-03-14
CN1649862A (zh) 2005-08-03
IL164773A0 (en) 2005-12-18
US7247644B2 (en) 2007-07-24
CN100436446C (zh) 2008-11-26
CA2480026A1 (en) 2003-11-06
SI1511741T1 (sl) 2013-02-28
JP2005529892A (ja) 2005-10-06
ZA200409552B (en) 2006-02-22

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU