EA200601880A1 - Замещенные производные 4-алкил- и 4-алканоилпиперидина и их применение в качестве антагонистов нейрокининов - Google Patents

Замещенные производные 4-алкил- и 4-алканоилпиперидина и их применение в качестве антагонистов нейрокининов

Info

Publication number
EA200601880A1
EA200601880A1 EA200601880A EA200601880A EA200601880A1 EA 200601880 A1 EA200601880 A1 EA 200601880A1 EA 200601880 A EA200601880 A EA 200601880A EA 200601880 A EA200601880 A EA 200601880A EA 200601880 A1 EA200601880 A1 EA 200601880A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonistic activity
neurokinins
alkyl
alkanoilpiperidine
antagonists
Prior art date
Application number
EA200601880A
Other languages
English (en)
Other versions
EA010312B1 (ru
Inventor
Франс Эдуард Янссенс
Франсуа Мария Соммен
Бенуа Кристиан Альберт Гилейн Де Бук
Йозеф Элизабет Ленартс
Original Assignee
Янссен Фармацевтика Н. В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н. В. filed Critical Янссен Фармацевтика Н. В.
Publication of EA200601880A1 publication Critical patent/EA200601880A1/ru
Publication of EA010312B1 publication Critical patent/EA010312B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к замещенным производным 4-алкил- и 4-алканоилпиперидина, обладающим антагонистической активностью к нейрокининам, в частности NKi антагонистической активностью и объединенной NK/NKантагонистической активностью, к содержащим их композициям и их применению в качестве лекарственного средства, в частности, для лечения и/или профилактики шизофрении, рвоты, тревоги и депрессии, синдрома раздраженного кишечника (СРК), нарушения циркадного ритма, преэклампсии, ноцицепции, боли, в частности висцеральной и невропатической боли, панкреатита, нейрогенного воспаления, астмы, хронического обструктивного заболевания легких (ХОЗЛ) и расстройств мочеиспускания, таких как недержание мочи. Соединения по изобретению могут быть представлены общей формулой (I), включая также их фармацевтически приемлемые аддитивные соли кислоты или основания, их стереохимически изомерные формы, формы N-оксида и пролекарства, где все заместители являются такими, как определено в п.1 формулы изобретения.
EA200601880A 2004-04-08 2005-04-04 Замещенные производные 4-алкил- и 4-алканоилпиперидина и их применение в качестве антагонистов нейрокининов EA010312B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04101467 2004-04-08
PCT/EP2005/051509 WO2005097774A1 (en) 2004-04-08 2005-04-04 Substituted 4-alkyl- and 4-alkanoyl-piperidine derivatives and their use as neurokinin antagonists

Publications (2)

Publication Number Publication Date
EA200601880A1 true EA200601880A1 (ru) 2007-02-27
EA010312B1 EA010312B1 (ru) 2008-08-29

Family

ID=34928945

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601880A EA010312B1 (ru) 2004-04-08 2005-04-04 Замещенные производные 4-алкил- и 4-алканоилпиперидина и их применение в качестве антагонистов нейрокининов

Country Status (23)

Country Link
US (1) US20070213346A1 (ru)
EP (1) EP1737838B1 (ru)
JP (1) JP2007532516A (ru)
KR (1) KR20070007347A (ru)
CN (1) CN1938291B (ru)
AR (1) AR048532A1 (ru)
AT (1) ATE396185T1 (ru)
AU (1) AU2005231986B2 (ru)
BR (1) BRPI0509720A (ru)
CA (1) CA2561967A1 (ru)
DE (1) DE602005007002D1 (ru)
EA (1) EA010312B1 (ru)
ES (1) ES2307169T3 (ru)
IL (1) IL178461A0 (ru)
JO (1) JO2525B1 (ru)
MX (1) MXPA06011683A (ru)
MY (1) MY142773A (ru)
NO (1) NO20065022L (ru)
NZ (1) NZ550098A (ru)
PA (1) PA8628901A1 (ru)
TW (1) TWI358298B (ru)
WO (1) WO2005097774A1 (ru)
ZA (1) ZA200608356B (ru)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8507530B2 (en) 2007-04-27 2013-08-13 Eisai R&D Management Co., Ltd. Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
US8841327B2 (en) 2005-10-31 2014-09-23 Eisai R&D Management Co., Ltd. Heterocycles substituted pyridine derivatives and antifungal agent containing thereof

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4769257B2 (ja) * 2005-02-23 2011-09-07 シェーリング コーポレイション ケモカインレセプターのインヒビターとして有用なピペリジニルピペラジン誘導体
US8895551B2 (en) 2009-04-02 2014-11-25 Shionogi & Co., Ltd. Acrylamide compounds and the use thereof
EP2623101B1 (en) 2009-04-02 2021-04-21 Merck Patent GmbH Piperidine and piperazine derivatives as autotaxin inhibitors
WO2011051478A1 (en) * 2009-10-30 2011-05-05 Domain Therapeutics Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors
WO2015036412A1 (en) * 2013-09-12 2015-03-19 F. Hoffmann-La Roche Ag Indol-carboxamide derivatives
HUE047732T2 (hu) 2015-05-18 2020-05-28 Nerre Therapeutics Ltd NK-1/NK-3 receptor antagonista vértolulások kezeléséhez
PL3765024T3 (pl) 2018-03-14 2024-08-05 KaNDy Therapeutics Limited <div>Nowa formulacja farmaceutyczna zawierająca podwójnych antagonistów receptora nk-1/nk-3</div>
ES2963356T3 (es) * 2019-06-12 2024-03-26 Nouryon Chemicals Int Bv Método para aislar ácido carboxílico a partir de una corriente lateral acuosa
US12215074B2 (en) 2019-06-12 2025-02-04 Nouryon Chemicals International B.V. Process for the production of peroxyesters
JP7336541B2 (ja) 2019-06-12 2023-08-31 ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ 過酸化ジアシルを生成するためのプロセス
EP3983370B1 (en) 2019-06-12 2023-08-02 Nouryon Chemicals International B.V. Process for the production of diacyl peroxides
WO2020249690A1 (en) 2019-06-12 2020-12-17 Nouryon Chemicals International B.V. Process for the production of diacyl peroxides
US12533358B1 (en) 2025-05-14 2026-01-27 Bayer Consumer Care Ag Methods of treatment with elinzanetant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ321575A (en) * 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives
TW382017B (en) * 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
GB0025354D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
US6642226B2 (en) * 2001-02-06 2003-11-04 Hoffman-La Roche Inc. Substituted phenyl-piperidine methanone compounds
US7514424B2 (en) * 2002-12-23 2009-04-07 Janssen Pharmaceutica N.V. Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841327B2 (en) 2005-10-31 2014-09-23 Eisai R&D Management Co., Ltd. Heterocycles substituted pyridine derivatives and antifungal agent containing thereof
US8507530B2 (en) 2007-04-27 2013-08-13 Eisai R&D Management Co., Ltd. Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same

Also Published As

Publication number Publication date
DE602005007002D1 (de) 2008-07-03
US20070213346A1 (en) 2007-09-13
AU2005231986B2 (en) 2011-02-24
JP2007532516A (ja) 2007-11-15
EP1737838A1 (en) 2007-01-03
MY142773A (en) 2010-12-31
WO2005097774A1 (en) 2005-10-20
AR048532A1 (es) 2006-05-03
ZA200608356B (en) 2008-07-30
EA010312B1 (ru) 2008-08-29
IL178461A0 (en) 2007-02-11
NZ550098A (en) 2009-10-30
BRPI0509720A (pt) 2007-09-25
KR20070007347A (ko) 2007-01-15
PA8628901A1 (es) 2006-09-08
TWI358298B (en) 2012-02-21
NO20065022L (no) 2006-11-03
TW200603797A (en) 2006-02-01
ES2307169T3 (es) 2008-11-16
JO2525B1 (en) 2010-03-17
ATE396185T1 (de) 2008-06-15
CA2561967A1 (en) 2005-10-20
MXPA06011683A (es) 2006-12-14
AU2005231986A1 (en) 2005-10-20
EP1737838B1 (en) 2008-05-21
CN1938291A (zh) 2007-03-28
CN1938291B (zh) 2011-11-16

Similar Documents

Publication Publication Date Title
TW200604198A (en) Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists
MY142090A (en) Substituted diaza-spiro-[5.5]-undecane derivatives and their use as neurokinin antagonists
TW200626142A (en) Chemical compounds
IL177291A0 (en) Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
WO2008080844A9 (en) Azaspiro derivatives
WO2007127635A3 (en) Diketo-piperazine and piperidine derivatives as antiviral agents
TW200603797A (en) Substituted 4-alkyl- and 4-alkanoyl-piperidine derivatives and their use as neurokinin antagonists
EA200501041A1 (ru) Замещенные производные 1-пиперидин-4-ил-4-пирролидин-3-илпиперазина и их применение в качестве антагонистов нейрокининов
UA92670C2 (ru) Пиразолиновые соединения и их фармацевтическое применение, композиция на их основе
MX2009005507A (es) Derivados de espiro-piperidina.
ATE354572T1 (de) Substituierte 1-piperidin-4-yl-4-azetidin-3-yl- piperazinderivate und deren verwendung als neurokininantagonisten
MX2009006454A (es) Derivados de espiro-piperidina.
EA200701879A1 (ru) Замещённые производные оксадиазаспиро [5.5] ундеканона и их применение в качестве антагонистов нейрокинина
MX2008001606A (es) Piperazinas substituidas como antagonistas de receptor de glutamato metabotropico.
MX2009005541A (es) Indoles que actuan como antagonistas del receptor v1a.
MX2009005544A (es) Indoles.
MX2009005504A (es) Derivados de espiro piperidina como antagonistas del receptor via.
MX2009006446A (es) Derivados de espiro-piperidina.
WO2006011024A3 (en) New tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
EA200701898A1 (ru) Производные диаза-спиро-[4.4]-нонана в качестве антагонистов нейрокинина (nk1)
TW200738588A (en) Chemical compounds
EA200501040A1 (ru) Замещенные производные 1-пиперидин-3-ил-4-пиперидин-4-илпиперазина и их применение в качестве антагонистов нейрокинина
MY145168A (en) Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists
DE602005022558D1 (de) Mikroemulsionsformulierungen mit bestimmten substanz p antagonisten
MX2025009690A (es) Antagonistas de receptores opioides kappa.

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU