EA200901432A1 - Новые аспарагиназы и их применение - Google Patents

Новые аспарагиназы и их применение

Info

Publication number
EA200901432A1
EA200901432A1 EA200901432A EA200901432A EA200901432A1 EA 200901432 A1 EA200901432 A1 EA 200901432A1 EA 200901432 A EA200901432 A EA 200901432A EA 200901432 A EA200901432 A EA 200901432A EA 200901432 A1 EA200901432 A1 EA 200901432A1
Authority
EA
Eurasian Patent Office
Prior art keywords
new
asparaginase
relates
variants
asparaginases
Prior art date
Application number
EA200901432A
Other languages
English (en)
Other versions
EA017305B1 (ru
Inventor
ВАН ДЕР Ян Метске ЛААН
Марк Кристиаан Стор
Де Илсе Ланге
Лисетте Морман
Original Assignee
ДСМ АйПи АССЕТС Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ДСМ АйПи АССЕТС Б.В. filed Critical ДСМ АйПи АССЕТС Б.В.
Publication of EA200901432A1 publication Critical patent/EA200901432A1/ru
Publication of EA017305B1 publication Critical patent/EA017305B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/06—Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
    • A23L5/25—Removal of unwanted matter, e.g. deodorisation or detoxification using enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01001—Asparaginase (3.5.1.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Настоящее изобретение касается аспарагиназы, у которой ширина рН-профиля активности составляет по меньшей мере 3,5 единицы рН. Изобретение также касается недавно идентифицированных полипептидов аспарагиназы согласно SEQ ID NO: 2 или SEQ ID NO: 4 и их вариантов, а также последовательностей полинуклеотидов, кодирующих эти новые варианты аспарагиназы. Кроме того, изобретение касается применения этих новых вариантов аспарагиназы в промышленных процессах.
EA200901432A 2007-04-20 2008-04-17 Новые аспарагиназы и их применение EA017305B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP07106660 2007-04-20
EP07106664 2007-04-20
EP07106662 2007-04-20
PCT/EP2008/054693 WO2008128975A1 (en) 2007-04-20 2008-04-17 Novel asparaginases and uses thereof

Publications (2)

Publication Number Publication Date
EA200901432A1 true EA200901432A1 (ru) 2010-04-30
EA017305B1 EA017305B1 (ru) 2012-11-30

Family

ID=39650693

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901432A EA017305B1 (ru) 2007-04-20 2008-04-17 Новые аспарагиназы и их применение

Country Status (14)

Country Link
US (3) US20100136169A1 (ru)
EP (1) EP2137306B1 (ru)
JP (1) JP2010524448A (ru)
AR (1) AR066410A1 (ru)
AU (1) AU2008240797A1 (ru)
BR (1) BRPI0810481B1 (ru)
CA (1) CA2682677A1 (ru)
CL (2) CL2008001128A1 (ru)
DK (1) DK2137306T3 (ru)
EA (1) EA017305B1 (ru)
ES (1) ES2550362T3 (ru)
IL (1) IL201018A0 (ru)
MX (1) MX2009011256A (ru)
WO (1) WO2008128975A1 (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6730832B1 (en) 2001-09-10 2004-05-04 Luis Mayan Dominguez High threonine producing lines of Nicotiana tobacum and methods for producing
US7666652B2 (en) 2007-03-09 2010-02-23 Novozymes A/S Asparaginases
EA018424B1 (ru) 2007-04-20 2013-07-30 ДСМ АйПи АССЕТС Б.В. Варианты фермента аспарагиназы и их применение
US20110129569A1 (en) 2009-11-26 2011-06-02 Dsm Ip Assets B.V. Method to produce fried vegetable products
US20120100249A1 (en) * 2010-04-27 2012-04-26 Dsm Ip Assets B.V. Novel asparaginase enzyme
WO2012007192A1 (en) * 2010-07-14 2012-01-19 Nestec S.A. Asparaginase from basidiomycetes
US9057087B2 (en) 2010-11-19 2015-06-16 Novozymes North America, Inc. Processes of producing a fermentation product
WO2012158320A1 (en) 2011-05-13 2012-11-22 Baker Hughes Incorporated Method of using asparaginase as a polyacrylamide enzyme breaker
BR112014006735B1 (pt) * 2011-09-21 2021-06-22 Reynolds Technologies, Inc Método de produção de uma planta de tabaco modificada e produto de tabaco
US8716571B2 (en) 2011-09-21 2014-05-06 Reynolds Technologies, Inc. Tobacco having reduced amounts of amino acids and methods for producing such lines
US9137958B2 (en) 2012-02-08 2015-09-22 Reynolds Technologies, Inc. Tobacco having altered amounts of environmental contaminants
PL2884857T3 (pl) * 2012-08-17 2017-07-31 Novozymes A/S Sposób wytwarzania produktu żywnościowego
US9828595B2 (en) * 2012-08-17 2017-11-28 Novozymes A/S Thermostable asparaginase variants and polynucleotides encoding same
CN106414789A (zh) 2013-11-21 2017-02-15 恩特格里斯公司 用于在等离子体系统中使用的室组件的表面涂层
WO2016001894A1 (en) 2014-07-04 2016-01-07 West Systems Srl Method and composition to reduce the formation of acrylamide in fresh or pre-fried foods to be subjected to heat treatment
CA2991325A1 (en) * 2015-07-07 2017-01-12 Renaissance Bioscience Corp. Development of an asparagine-reducing yeast by adaptive evolution and uses thereof to reduce acrylamide formation
WO2019083794A1 (en) 2017-10-27 2019-05-02 Pfenex Inc. PROCESS FOR PRODUCING EAR ASPARAGINASE. RECOMBINED COLI
JP7784804B2 (ja) 2017-10-27 2025-12-12 フェネックス インク． 組み換えｅｒｗｉｎｉａアスパラギナーゼの製造のための方法
US20210299233A1 (en) 2018-07-12 2021-09-30 The Children's Medical Center Corporation Method for treating cancer
WO2022211829A1 (en) 2021-03-30 2022-10-06 Jazz Pharmaceuticals Ireland Ltd. Dosing of recombinant l-asparaginase
CN119630280A (zh) 2022-05-14 2025-03-14 诺维信公司 用于预防、处理、抑制和/或消除植物病原性侵染和感染的组合物和方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3819540B2 (ja) * 1996-06-07 2006-09-13 株式会社林原生物化学研究所 Ｌ−アスパラギナーゼ活性を有する哺乳類由来のポリペプチド
US7037540B2 (en) 2002-09-19 2006-05-02 Frito-Lay North America, Inc. Method for reducing acrylamide formation in thermally processed foods
US7524519B2 (en) * 2002-09-20 2009-04-28 The Procter & Gamble Company Method for reducing acrylamide in foods, foods having reduced levels of acrylamide, and article of commerce
ES2533469T3 (es) 2002-10-11 2015-04-10 Novozymes A/S Método de preparación de un producto tratado con calor
US20040101607A1 (en) 2002-11-22 2004-05-27 The Procter & Gamble Company Method for reducing acrylamide in foods, foods having reduced levels of acrylamide, and article of commerce
US8105815B2 (en) 2002-12-19 2012-01-31 Dsm Ip Assets B.V. Asparaginase and its use in food production

Also Published As

Publication number Publication date
IL201018A0 (en) 2011-08-01
ES2550362T3 (es) 2015-11-06
US20100136169A1 (en) 2010-06-03
JP2010524448A (ja) 2010-07-22
CL2008001128A1 (es) 2008-06-13
EP2137306A1 (en) 2009-12-30
US20130023029A1 (en) 2013-01-24
EP2137306B1 (en) 2015-07-29
WO2008128975A1 (en) 2008-10-30
US8323948B2 (en) 2012-12-04
BRPI0810481A2 (pt) 2014-10-07
MX2009011256A (es) 2009-11-05
CA2682677A1 (en) 2008-10-30
AR066410A1 (es) 2009-08-19
BRPI0810481B1 (pt) 2022-05-17
EA017305B1 (ru) 2012-11-30
CL2008001129A1 (es) 2008-06-13
AU2008240797A1 (en) 2008-10-30
DK2137306T3 (en) 2015-10-26
US20120045549A1 (en) 2012-02-23

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU