EA201400701A1 - Замещенные соединения пиразоло[1,5-a]пиридина в качестве ингибиторов тропомиозинрецепторной киназы (trk) - Google Patents

Замещенные соединения пиразоло[1,5-a]пиридина в качестве ингибиторов тропомиозинрецепторной киназы (trk)

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Publication number
EA201400701A1
EA201400701A1 EA201400701A EA201400701A EA201400701A1 EA 201400701 A1 EA201400701 A1 EA 201400701A1 EA 201400701 A EA201400701 A EA 201400701A EA 201400701 A EA201400701 A EA 201400701A EA 201400701 A1 EA201400701 A1 EA 201400701A1
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EA
Eurasian Patent Office
Prior art keywords
trk
pyridine
pyrazolo
tripomyosinreceptor
kinase inhibitors
Prior art date
Application number
EA201400701A
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English (en)
Other versions
EA025352B1 (ru
Inventor
Прадип Кумар Сасмал
Шахадат Ахмед
Ашок Техим
Видьядхар Парадкар
Прасанна М. Даттатрея
Нанйеговда Йагадееш Мавинахалли
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Др. Редди'С Лабораториз Лтд.
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Application filed by Др. Редди'С Лабораториз Лтд. filed Critical Др. Редди'С Лабораториз Лтд.
Publication of EA201400701A1 publication Critical patent/EA201400701A1/ru
Publication of EA025352B1 publication Critical patent/EA025352B1/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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Abstract

Изобретение относится к сериям замещенных пиразоло[1,5-а]пиридиновых соединений, их применению в качестве ингибиторов протеинкиназ семейства тропомиозинрецепторной киназы (Trk), способу получения и фармацевтическим композициям, содержащим такие соединения.
EA201400701A 2011-12-12 2012-12-12 ЗАМЕЩЕННЫЕ СОЕДИНЕНИЯ ПИРАЗОЛО[1,5-a]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ТРОПОМИОЗИН-РЕЦЕПТОРНОЙ КИНАЗЫ (Trk) EA025352B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4329CH2011 2011-12-12
PCT/IB2012/003012 WO2013088256A1 (en) 2011-12-12 2012-12-12 Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (trk) inhibitors

Publications (2)

Publication Number Publication Date
EA201400701A1 true EA201400701A1 (ru) 2014-11-28
EA025352B1 EA025352B1 (ru) 2016-12-30

Family

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EA201400701A EA025352B1 (ru) 2011-12-12 2012-12-12 ЗАМЕЩЕННЫЕ СОЕДИНЕНИЯ ПИРАЗОЛО[1,5-a]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ТРОПОМИОЗИН-РЕЦЕПТОРНОЙ КИНАЗЫ (Trk)

Country Status (16)

Country Link
US (7) US9045478B2 (ru)
EP (2) EP2791138B1 (ru)
JP (1) JP5990595B2 (ru)
KR (2) KR20140105508A (ru)
CN (1) CN104114553B (ru)
AU (1) AU2012351748B2 (ru)
BR (1) BR112014014276A2 (ru)
CA (1) CA2858958C (ru)
CL (1) CL2014001529A1 (ru)
CO (1) CO7071124A2 (ru)
DK (1) DK2791138T3 (ru)
EA (1) EA025352B1 (ru)
ES (1) ES2686501T3 (ru)
IL (1) IL233067B (ru)
MX (1) MX356401B (ru)
WO (2) WO2013088257A1 (ru)

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CN102264736B (zh) 2008-10-22 2013-08-14 阵列生物制药公司 作为TRK激酶抑制剂的取代的吡唑并[1,5-a]嘧啶化合物
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
BR122019024201B1 (pt) 2010-05-20 2021-08-03 Array Biopharma Inc Composto macrocíclico como inibidores de trk quinase, seu uso, e composição farmacêutica
KR20140105508A (ko) * 2011-12-12 2014-09-01 닥터 레디스 레보러터리즈 리미티드 트로포미오신 수용체 키나제(Trk) 억제제인 치환된 피라졸로[1,5-a]피리딘
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JP2016540811A (ja) 2013-12-20 2016-12-28 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ Ｎ−アシルピペリジンエーテルトロポミオシン関連キナーゼ阻害剤
CN103819343B (zh) * 2014-02-17 2016-03-23 青岛农业大学 化合物2-烯丙基-4-氟-6-硝基苯酚的制备方法和农用生物活性
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
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AU2015257746B2 (en) * 2014-05-08 2018-11-22 Bayer Cropscience Aktiengesellschaft Pyrazolopyridine sulfonamides as nematicides
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