EA201400939A1 - Способ получения медетомидина с использованием хлорацетона - Google Patents

Способ получения медетомидина с использованием хлорацетона

Info

Publication number
EA201400939A1
EA201400939A1 EA201400939A EA201400939A EA201400939A1 EA 201400939 A1 EA201400939 A1 EA 201400939A1 EA 201400939 A EA201400939 A EA 201400939A EA 201400939 A EA201400939 A EA 201400939A EA 201400939 A1 EA201400939 A1 EA 201400939A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methetomidine
chlorocetone
obtaining
medetomidine
chloroacetone
Prior art date
Application number
EA201400939A
Other languages
English (en)
Other versions
EA027921B1 (ru
Inventor
Флоренсио Сарагоса Дёрвальд
Анна Кулеша
Штефан Эльцнер
Роберт Буйок
Збигнев Вробель
Кшиштов Войцеховски
Original Assignee
Лонца Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47557694&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201400939(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2012/070875 external-priority patent/WO2012172121A1/en
Application filed by Лонца Лтд. filed Critical Лонца Лтд.
Publication of EA201400939A1 publication Critical patent/EA201400939A1/ru
Publication of EA027921B1 publication Critical patent/EA027921B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

Изобретение раскрывает способ получения медетомидина исходя из 1-бром 2,3-диметилбензола и хлорацетона.
EA201400939A 2012-06-28 2012-11-15 Способ получения медетомидина с использованием хлорацетона EA027921B1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261665510P 2012-06-28 2012-06-28
EP12174102 2012-06-28
EP12188104 2012-10-11
PCT/EP2012/070875 WO2012172121A1 (en) 2012-06-28 2012-10-22 Method for the preparation of medetomidine with chloroacetone
EP12192625 2012-11-14
PCT/EP2012/072798 WO2013011157A1 (en) 2012-06-28 2012-11-15 Method for preparation of medetomidine with chloroacetone

Publications (2)

Publication Number Publication Date
EA201400939A1 true EA201400939A1 (ru) 2015-01-30
EA027921B1 EA027921B1 (ru) 2017-09-29

Family

ID=47557694

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400939A EA027921B1 (ru) 2012-06-28 2012-11-15 Способ получения медетомидина с использованием хлорацетона

Country Status (20)

Country Link
US (2) US9156793B2 (ru)
EP (1) EP2867211B1 (ru)
JP (1) JP5777841B2 (ru)
KR (1) KR101560116B1 (ru)
CN (2) CN104245678B (ru)
AU (1) AU2012285677B2 (ru)
CA (1) CA2866437C (ru)
CL (2) CL2014002907A1 (ru)
CY (1) CY1117492T1 (ru)
DK (1) DK2867211T3 (ru)
EA (1) EA027921B1 (ru)
ES (1) ES2565066T3 (ru)
HR (1) HRP20160216T1 (ru)
HU (1) HUE027382T2 (ru)
IN (1) IN2014DN07984A (ru)
MY (1) MY165218A (ru)
PL (1) PL2867211T3 (ru)
SG (1) SG11201405609WA (ru)
TW (2) TWI560182B (ru)
WO (1) WO2013011157A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2557638T3 (es) 2012-05-08 2016-01-27 Lonza Ltd Método para la preparación de 2-(2,3-dimetilfenil)-1-propanal
IN2014DN07983A (ru) * 2012-05-08 2015-05-01 Lonza Ag
JP5777841B2 (ja) * 2012-06-28 2015-09-09 ロンザ・リミテッド クロロアセトンを用いてメデトミジンを調製するための方法
IN2014DN08121A (ru) * 2012-06-28 2015-05-01 Lonza Ag
RU2718960C2 (ru) * 2016-02-12 2020-04-15 Сони Корпорейшн Устройство и способ
CN106518812A (zh) * 2016-10-25 2017-03-22 湖南大学 一种美托咪定及其中间体的制备方法
CN113044857B (zh) * 2020-12-30 2023-05-23 重庆柒兴克米科技有限公司 高收率制取高纯氰化钠或氰化钾的生产工艺
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

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USRE23400E (en) 1951-08-14 Electkic low and high-voltage fuses
BE790604A (fr) 1971-10-28 1973-04-26 Sandoz Sa Nouveaux aminoalcanols, leur preparation et leur application comme medicaments
JPS51100042A (en) 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
JPS51100041A (en) 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
GB2092569B (en) 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2101114B (en) 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
DE3586403T2 (de) 1984-02-24 1993-02-04 Sagami Chem Res Methode zum isomerisieren eines glycidats.
JPS62103037A (ja) * 1985-10-29 1987-05-13 Hamari Yakuhin Kogyo Kk ２−（４−イソブチルフエニル）−プロピオンアルデヒドの製造法
DE19714042A1 (de) 1997-04-05 1998-10-08 Henkel Kgaa Verfahren zur Herstellung aromatischer Aldehyde
SE513474C2 (sv) 1999-01-25 2000-09-18 Hans Elwing Instutionen Foer C Metod för att förhindra kräftdjurs, särskilt havstulpaners, etablering på fasta ytor med hjälp av en substans som stör nervsignaler, varvid substansen är medetomidin, dvs (+)-4-/1- (2,3-dimetylfenyl)-etyl/-IH-imidazol
EP1918282A1 (en) * 2006-11-06 2008-05-07 "Joint Stock Company Grindeks" Method for preparing medetomidine and its salts
GB2453982B (en) 2007-10-24 2009-09-16 Norbrook Lab Ltd Chemical process for the preparation of Medetomidine
US7902247B2 (en) 2008-01-09 2011-03-08 Allergan, Inc. Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors
CN101921234B (zh) * 2009-06-12 2012-05-30 中国中化股份有限公司 一种制备美托咪啶的方法
CN102753532B (zh) * 2009-12-09 2015-05-13 I-技术有限公司 美托咪定的制备方法
ES2557638T3 (es) 2012-05-08 2016-01-27 Lonza Ltd Método para la preparación de 2-(2,3-dimetilfenil)-1-propanal
IN2014DN07983A (ru) * 2012-05-08 2015-05-01 Lonza Ag
WO2012172120A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd 2-(2,3-dimethylphenyl)-1-propanal and its use as perfume
WO2012172119A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
WO2012172122A2 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
IN2014DN08121A (ru) 2012-06-28 2015-05-01 Lonza Ag
JP5777841B2 (ja) * 2012-06-28 2015-09-09 ロンザ・リミテッド クロロアセトンを用いてメデトミジンを調製するための方法
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone

Also Published As

Publication number Publication date
HRP20160216T1 (hr) 2016-03-25
HUE027382T2 (en) 2016-10-28
ES2565066T3 (es) 2016-03-31
CL2016001664A1 (es) 2017-01-27
EA027921B1 (ru) 2017-09-29
DK2867211T3 (en) 2016-02-29
CN105218453A (zh) 2016-01-06
WO2013011157A1 (en) 2013-01-24
KR20140129399A (ko) 2014-11-06
US20150099889A1 (en) 2015-04-09
MY165218A (en) 2018-03-09
TWI560182B (en) 2016-12-01
EP2867211B1 (en) 2015-12-30
JP2015517474A (ja) 2015-06-22
PL2867211T3 (pl) 2016-06-30
CN104245678A (zh) 2014-12-24
CL2014002907A1 (es) 2015-01-16
TW201402553A (zh) 2014-01-16
IN2014DN07984A (ru) 2015-05-01
EP2867211A1 (en) 2015-05-06
US20150336909A1 (en) 2015-11-26
CN105218453B (zh) 2017-04-12
SG11201405609WA (en) 2015-02-27
CA2866437A1 (en) 2013-01-24
HK1201530A1 (zh) 2015-09-04
NZ700642A (en) 2016-04-29
US9156793B2 (en) 2015-10-13
US9434694B2 (en) 2016-09-06
TW201630888A (zh) 2016-09-01
JP5777841B2 (ja) 2015-09-09
TWI543970B (zh) 2016-08-01
HK1213893A1 (zh) 2016-07-15
CN104245678B (zh) 2016-02-24
AU2012285677A1 (en) 2014-09-25
AU2012285677B2 (en) 2016-03-31
KR101560116B1 (ko) 2015-10-13
CY1117492T1 (el) 2017-04-26
CA2866437C (en) 2018-01-02

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU