EA201401150A1 - Аминоиндолилзамещенные имидазолпиримидины и их применение в качестве лекарственных средств - Google Patents
Аминоиндолилзамещенные имидазолпиримидины и их применение в качестве лекарственных средствInfo
- Publication number
- EA201401150A1 EA201401150A1 EA201401150A EA201401150A EA201401150A1 EA 201401150 A1 EA201401150 A1 EA 201401150A1 EA 201401150 A EA201401150 A EA 201401150A EA 201401150 A EA201401150 A EA 201401150A EA 201401150 A1 EA201401150 A1 EA 201401150A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- aminoindolyl
- substituted
- imidazolpyrimidines
- medicines
- application
- Prior art date
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract
В заявке описаны новые аминоиндолилзамещенные имидазолилпиримидины формулы (1)в которой R, R, R, Rи Rявляются такими, как определено в п.1 формулы изобретения, и их фармацевтически приемлемые соли, и применение этих соединений для приготовления лекарственного средства, предназначенного для лечения заболевания, выбранного из группы, включающей астму, ХОЗЛ, ревматоидный артрит, определенные лимфомы и определенные заболевания нервной системы.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12164861 | 2012-04-20 | ||
| PCT/EP2013/058203 WO2013156608A1 (en) | 2012-04-20 | 2013-04-19 | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201401150A1 true EA201401150A1 (ru) | 2015-04-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201401150A EA201401150A1 (ru) | 2012-04-20 | 2013-04-19 | Аминоиндолилзамещенные имидазолпиримидины и их применение в качестве лекарственных средств |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9096579B2 (ru) |
| EP (1) | EP2838895B1 (ru) |
| JP (1) | JP6182592B2 (ru) |
| KR (1) | KR20150003743A (ru) |
| CN (1) | CN104334553A (ru) |
| AU (1) | AU2013251073A1 (ru) |
| CA (1) | CA2870767A1 (ru) |
| CL (1) | CL2014002732A1 (ru) |
| EA (1) | EA201401150A1 (ru) |
| IL (1) | IL234628A0 (ru) |
| MX (1) | MX2014012574A (ru) |
| PH (1) | PH12014502341A1 (ru) |
| WO (1) | WO2013156608A1 (ru) |
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| PT3426243T (pt) | 2016-03-09 | 2021-08-19 | Raze Therapeutics Inc | Inibidores de 3-fosfoglicerato desidrogenase e utilizações dos mesmos |
| WO2017156177A1 (en) * | 2016-03-09 | 2017-09-14 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
| EP3426244B1 (en) | 2016-03-09 | 2023-06-07 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
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| AU2018208422B2 (en) | 2017-01-10 | 2021-11-11 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
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| WO2019000683A1 (zh) * | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| CN110573501B (zh) | 2017-06-30 | 2023-09-29 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| AU2018294054B2 (en) | 2017-06-30 | 2022-05-26 | Beijing Tide Pharmaceutical Co., Ltd. | Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof |
| CN107739368B (zh) * | 2017-10-13 | 2020-02-14 | 厦门大学 | N-取代-5-((4-取代嘧啶-2-基)氨基)吲哚类衍生物及其制备方法和用途 |
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| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020092395A1 (en) | 2018-10-29 | 2020-05-07 | Forma Therapeutics, Inc. | SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE |
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| KR20210108414A (ko) | 2018-12-25 | 2021-09-02 | 솔-겔 테크놀로지스 리미티드 | Egfr 억제제를 포함하는 조성물에 의한 피부 장애 치료 |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| WO2020221826A1 (en) * | 2019-04-30 | 2020-11-05 | Aicuris Gmbh & Co. Kg | Novel indole-2-carboxamides active against the hepatitis b virus (hbv) |
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| CN119930611A (zh) | 2019-10-11 | 2025-05-06 | 因赛特公司 | 作为cdk2抑制剂的双环胺 |
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| GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
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| DE50103666D1 (de) | 2000-10-12 | 2004-10-21 | Boehringer Ingelheim Pharma | Kristallines monohydrat von tiotropiumbromid, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels |
| AR035700A1 (es) | 2001-05-08 | 2004-06-23 | Astrazeneca Ab | Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados |
| CA2446756C (en) | 2001-06-01 | 2011-03-08 | Vertex Pharmaceuticals Incorporated | Thiazole compounds useful as inhibitors of protein kinase |
| PL208137B1 (pl) | 2001-06-22 | 2011-03-31 | Boehringer Ingelheim Pharma | Bezwodny krystaliczny bromek tiotropium, sposób jego wytwarzania i zastosowanie krystalicznego monohydratu bromku tiotropium do wytwarzania krystalicznego bezwodnego bromku tiotropium |
| SE0203304D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Coumpounds |
| ATE425160T1 (de) | 2002-12-18 | 2009-03-15 | Vertex Pharma | Benzisoxazolderivate, die sich als inhibitoren von proteinkinasen eigen |
| WO2004087698A2 (en) | 2003-03-25 | 2004-10-14 | Vertex Pharmaceuticals Incorporated | Thiazoles useful as inhibitors of protein kinases |
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| WO2007085540A1 (en) | 2006-01-27 | 2007-08-02 | Glaxo Group Limited | 1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives |
| PE20081834A1 (es) | 2006-12-31 | 2009-01-16 | Boehringer Ingelheim Int | Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos |
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| KR101116756B1 (ko) | 2009-10-27 | 2012-03-13 | 한국과학기술연구원 | 단백질 키나아제 저해활성을 갖는 신규의 1,6-치환된 인돌 화합물 |
| US8629132B2 (en) | 2009-11-13 | 2014-01-14 | Genosco | Kinase inhibitors |
| EP2512246B1 (en) | 2009-12-17 | 2015-09-30 | Merck Sharp & Dohme Corp. | Aminopyrimidines as syk inhibitors |
| WO2011075517A1 (en) | 2009-12-17 | 2011-06-23 | Merck Sharp & Dohme Corp. | Aminopyrimidines as syk inhibitors |
| TWI523852B (zh) | 2010-01-12 | 2016-03-01 | Ab科學公司 | 經取代之唑衍生物、含彼之組合物及其用途 |
| JP5959537B2 (ja) * | 2011-01-28 | 2016-08-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換ピリジニル−ピリミジン及び医薬としてのその使用 |
-
2013
- 2013-04-17 US US13/864,394 patent/US9096579B2/en active Active
- 2013-04-19 CA CA2870767A patent/CA2870767A1/en not_active Abandoned
- 2013-04-19 AU AU2013251073A patent/AU2013251073A1/en not_active Abandoned
- 2013-04-19 EA EA201401150A patent/EA201401150A1/ru unknown
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- 2013-04-19 JP JP2015506257A patent/JP6182592B2/ja active Active
- 2013-04-19 KR KR1020147029236A patent/KR20150003743A/ko not_active Withdrawn
- 2013-04-19 WO PCT/EP2013/058203 patent/WO2013156608A1/en not_active Ceased
- 2013-04-19 MX MX2014012574A patent/MX2014012574A/es unknown
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2014
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- 2014-10-20 PH PH12014502341A patent/PH12014502341A1/en unknown
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| US20130281430A1 (en) | 2013-10-24 |
| IL234628A0 (en) | 2014-11-30 |
| CA2870767A1 (en) | 2013-10-24 |
| CL2014002732A1 (es) | 2015-01-23 |
| WO2013156608A1 (en) | 2013-10-24 |
| JP2015514738A (ja) | 2015-05-21 |
| US9096579B2 (en) | 2015-08-04 |
| EP2838895B1 (en) | 2016-07-13 |
| AU2013251073A1 (en) | 2014-10-02 |
| KR20150003743A (ko) | 2015-01-09 |
| CN104334553A (zh) | 2015-02-04 |
| EP2838895A1 (en) | 2015-02-25 |
| MX2014012574A (es) | 2014-11-21 |
| JP6182592B2 (ja) | 2017-08-16 |
| PH12014502341A1 (en) | 2014-12-22 |
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