EA201401150A1 - Аминоиндолилзамещенные имидазолпиримидины и их применение в качестве лекарственных средств - Google Patents
Аминоиндолилзамещенные имидазолпиримидины и их применение в качестве лекарственных средствInfo
- Publication number
- EA201401150A1 EA201401150A1 EA201401150A EA201401150A EA201401150A1 EA 201401150 A1 EA201401150 A1 EA 201401150A1 EA 201401150 A EA201401150 A EA 201401150A EA 201401150 A EA201401150 A EA 201401150A EA 201401150 A1 EA201401150 A1 EA 201401150A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- aminoindolyl
- substituted
- imidazolpyrimidines
- medicines
- application
- Prior art date
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract
В заявке описаны новые аминоиндолилзамещенные имидазолилпиримидины формулы (1)в которой R, R, R, Rи Rявляются такими, как определено в п.1 формулы изобретения, и их фармацевтически приемлемые соли, и применение этих соединений для приготовления лекарственного средства, предназначенного для лечения заболевания, выбранного из группы, включающей астму, ХОЗЛ, ревматоидный артрит, определенные лимфомы и определенные заболевания нервной системы.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12164861 | 2012-04-20 | ||
| PCT/EP2013/058203 WO2013156608A1 (en) | 2012-04-20 | 2013-04-19 | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201401150A1 true EA201401150A1 (ru) | 2015-04-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201401150A EA201401150A1 (ru) | 2012-04-20 | 2013-04-19 | Аминоиндолилзамещенные имидазолпиримидины и их применение в качестве лекарственных средств |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9096579B2 (ru) |
| EP (1) | EP2838895B1 (ru) |
| JP (1) | JP6182592B2 (ru) |
| KR (1) | KR20150003743A (ru) |
| CN (1) | CN104334553A (ru) |
| AU (1) | AU2013251073A1 (ru) |
| CA (1) | CA2870767A1 (ru) |
| CL (1) | CL2014002732A1 (ru) |
| EA (1) | EA201401150A1 (ru) |
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| MX (1) | MX2014012574A (ru) |
| PH (1) | PH12014502341A1 (ru) |
| WO (1) | WO2013156608A1 (ru) |
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| EP4234552A3 (en) * | 2016-03-09 | 2023-10-18 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
| LT3426243T (lt) | 2016-03-09 | 2021-08-10 | Raze Therapeutics, Inc. | 3-fosfogliceratdehidrogenazės inhibitoriai ir jų panaudojimas |
| WO2018058109A1 (en) | 2016-09-26 | 2018-03-29 | Nusirt Sciences, Inc. | Compositions and methods for treating metabolic disorders |
| AU2018208422B2 (en) | 2017-01-10 | 2021-11-11 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
| MX2019008229A (es) | 2017-01-10 | 2019-10-24 | Bayer Ag | Derivados heterociclicos como agentes de control de plagas. |
| US10323023B2 (en) | 2017-06-30 | 2019-06-18 | Beijing Tide Pharmaceutical Co., Ltd. | Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof |
| CN110582489B (zh) | 2017-06-30 | 2023-10-27 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| WO2019000682A1 (zh) | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| CN107739368B (zh) * | 2017-10-13 | 2020-02-14 | 厦门大学 | N-取代-5-((4-取代嘧啶-2-基)氨基)吲哚类衍生物及其制备方法和用途 |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| US10793554B2 (en) | 2018-10-29 | 2020-10-06 | Forma Therapeutics, Inc. | Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone |
| PY1991603A (es) * | 2018-11-02 | 2020-09-17 | Aicuris Gmbh & Co Kg | Nueva 6,7-dihidro-4h-pirazolo [1,5-a] pirazina indole -2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
| AR117189A1 (es) * | 2018-11-02 | 2021-07-21 | Aicuris Gmbh & Co Kg | Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb) |
| US11633399B2 (en) | 2018-12-25 | 2023-04-25 | Sol-Gel Technologies Ltd. | Treatment of skin disorders with compositions comprising an EGFR inhibitor |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| WO2020180959A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| SG11202111236UA (en) * | 2019-04-30 | 2021-11-29 | Aicuris Gmbh & Co Kg | Novel indole-2-carboxamides active against the hepatitis b virus (hbv) |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
| TW202115024A (zh) | 2019-08-14 | 2021-04-16 | 美商英塞特公司 | 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物 |
| AU2020364007A1 (en) | 2019-10-11 | 2022-04-28 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| US20230247994A1 (en) | 2020-07-02 | 2023-08-10 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
| US12404261B2 (en) | 2020-12-22 | 2025-09-02 | Novartis Ag | Compounds and compositions for treating conditions associated with cGAS |
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| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
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| GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9622363D0 (en) | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
| JP2003520042A (ja) | 2000-01-24 | 2003-07-02 | アイシス・ファーマシューティカルス・インコーポレーテッド | 誘導性一酸化窒素シンターゼ発現のアンチセンスモジュレーション |
| GB0004153D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| CN100519558C (zh) | 2000-10-12 | 2009-07-29 | 贝林格尔英格海姆法玛两合公司 | 结晶单水合物、其制备方法及其在制备药物组合中的用途 |
| AR035700A1 (es) | 2001-05-08 | 2004-06-23 | Astrazeneca Ab | Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados |
| CA2446756C (en) | 2001-06-01 | 2011-03-08 | Vertex Pharmaceuticals Incorporated | Thiazole compounds useful as inhibitors of protein kinase |
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| US7226919B2 (en) | 2002-12-18 | 2007-06-05 | Vertex Pharmaceuticals Inc. | Compositions useful as inhibitors of protein kinases |
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| ATE396731T1 (de) | 2003-03-25 | 2008-06-15 | Vertex Pharma | Thiazole zur verwendung als inhibitoren von protein-kinasen |
| WO2007085540A1 (en) | 2006-01-27 | 2007-08-02 | Glaxo Group Limited | 1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives |
| PE20081834A1 (es) | 2006-12-31 | 2009-01-16 | Boehringer Ingelheim Int | Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos |
| ATE523508T1 (de) | 2007-10-25 | 2011-09-15 | Astrazeneca Ab | Für die behandlung von zellproliferativen erkrankungen geeignete pyridin- und pyrazinderivate |
| KR101116756B1 (ko) | 2009-10-27 | 2012-03-13 | 한국과학기술연구원 | 단백질 키나아제 저해활성을 갖는 신규의 1,6-치환된 인돌 화합물 |
| MX2012005332A (es) | 2009-11-13 | 2012-10-15 | Oscotec Inc | Inhibidores de cinasa. |
| WO2011075517A1 (en) | 2009-12-17 | 2011-06-23 | Merck Sharp & Dohme Corp. | Aminopyrimidines as syk inhibitors |
| US8735417B2 (en) | 2009-12-17 | 2014-05-27 | Merck Sharp & Dohme Corp. | Aminopyrimidines as Syk inhibitors |
| MX2012008083A (es) | 2010-01-12 | 2012-08-15 | Ab Science | Inhibidores de triazol y oxazol quinaza. |
| JP5959537B2 (ja) * | 2011-01-28 | 2016-08-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換ピリジニル−ピリミジン及び医薬としてのその使用 |
-
2013
- 2013-04-17 US US13/864,394 patent/US9096579B2/en active Active
- 2013-04-19 MX MX2014012574A patent/MX2014012574A/es unknown
- 2013-04-19 JP JP2015506257A patent/JP6182592B2/ja active Active
- 2013-04-19 CA CA2870767A patent/CA2870767A1/en not_active Abandoned
- 2013-04-19 EP EP13717507.1A patent/EP2838895B1/en active Active
- 2013-04-19 WO PCT/EP2013/058203 patent/WO2013156608A1/en not_active Ceased
- 2013-04-19 AU AU2013251073A patent/AU2013251073A1/en not_active Abandoned
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- 2013-04-19 EA EA201401150A patent/EA201401150A1/ru unknown
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- 2014-10-20 PH PH12014502341A patent/PH12014502341A1/en unknown
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| IL234628A0 (en) | 2014-11-30 |
| CL2014002732A1 (es) | 2015-01-23 |
| KR20150003743A (ko) | 2015-01-09 |
| JP2015514738A (ja) | 2015-05-21 |
| EP2838895B1 (en) | 2016-07-13 |
| MX2014012574A (es) | 2014-11-21 |
| EP2838895A1 (en) | 2015-02-25 |
| CN104334553A (zh) | 2015-02-04 |
| AU2013251073A1 (en) | 2014-10-02 |
| CA2870767A1 (en) | 2013-10-24 |
| PH12014502341A1 (en) | 2014-12-22 |
| JP6182592B2 (ja) | 2017-08-16 |
| WO2013156608A1 (en) | 2013-10-24 |
| US20130281430A1 (en) | 2013-10-24 |
| US9096579B2 (en) | 2015-08-04 |
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