EA201401212A1 - Производные пирролотриазинона - Google Patents

Производные пирролотриазинона

Info

Publication number
EA201401212A1
EA201401212A1 EA201401212A EA201401212A EA201401212A1 EA 201401212 A1 EA201401212 A1 EA 201401212A1 EA 201401212 A EA201401212 A EA 201401212A EA 201401212 A EA201401212 A EA 201401212A EA 201401212 A1 EA201401212 A1 EA 201401212A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolotriazinone
derivatives
diseases
tankyrase
parp
Prior art date
Application number
EA201401212A
Other languages
English (en)
Other versions
EA027628B1 (ru
Inventor
Дитер Дорш
Ханс-Петер Бухшталлер
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201401212A1 publication Critical patent/EA201401212A1/ru
Publication of EA027628B1 publication Critical patent/EA027628B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

Соединения формулы Iв которой X, Rи Y имеют значения, указанные в п.1, являются ингибиторами танкиразы и PARP-1 и могут применяться, среди прочего, для лечения заболеваний, таких как злокачественное новообразование, сердечно-сосудистые заболевания, поражения центральной нервной системы и различные формы воспаления.
EA201401212A 2012-05-04 2013-04-06 Производные пирролотриазинона EA027628B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12003445 2012-05-04
PCT/EP2013/001026 WO2013164061A1 (en) 2012-05-04 2013-04-06 Pyrrolotriazinone derivatives

Publications (2)

Publication Number Publication Date
EA201401212A1 true EA201401212A1 (ru) 2015-08-31
EA027628B1 EA027628B1 (ru) 2017-08-31

Family

ID=48050660

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201401212A EA027628B1 (ru) 2012-05-04 2013-04-06 Производные пирролотриазинона

Country Status (21)

Country Link
US (1) US9174995B2 (ru)
EP (1) EP2844659B1 (ru)
JP (1) JP6097820B2 (ru)
KR (1) KR20150006873A (ru)
CN (1) CN104271580B (ru)
AR (1) AR090896A1 (ru)
AU (1) AU2013257018B2 (ru)
CA (1) CA2872334C (ru)
EA (1) EA027628B1 (ru)
ES (1) ES2587939T3 (ru)
HR (1) HRP20161033T1 (ru)
HU (1) HUE028325T2 (ru)
IL (1) IL235414A (ru)
MX (1) MX357502B (ru)
PL (1) PL2844659T3 (ru)
PT (1) PT2844659T (ru)
RS (1) RS55062B1 (ru)
SG (1) SG11201406997WA (ru)
SI (1) SI2844659T1 (ru)
WO (1) WO2013164061A1 (ru)
ZA (1) ZA201408876B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2865511A1 (en) 2012-03-07 2013-09-12 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
US9611223B2 (en) 2013-09-11 2017-04-04 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
NO3087076T3 (ru) * 2013-12-23 2018-02-24
UY36060A (es) 2014-04-02 2015-10-30 Bayer Pharma AG Compuestos de azol sustituidos con amida
WO2015154630A1 (zh) * 2014-04-10 2015-10-15 南京明德新药研发股份有限公司 作为PARP抑制剂的4H-吡唑并[1,5-α]苯并咪唑化合物的类似物
KR20160007347A (ko) * 2014-07-11 2016-01-20 에스티팜 주식회사 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도
KR101775356B1 (ko) * 2015-07-06 2017-09-06 재단법인 아산사회복지재단 Parp 및 탄키라제 동시 저해제에 대한 감수성 결정 방법
DK3356345T3 (da) 2015-09-30 2024-02-12 Max Planck Gesellschaft Heteroaryl-derivater som sepiapterin-reduktase-inhibitorer
WO2017055316A1 (en) 2015-10-01 2017-04-06 Bayer Pharma Aktiengesellschaft Amido-substituted azole compounds
WO2017055313A1 (en) 2015-10-01 2017-04-06 Bayer Pharma Aktiengesellschaft Amido-substituted azole compounds
PL3377495T3 (pl) 2015-11-16 2022-05-16 Topadur Pharma Ag Pochodne 2-fenylo-3,4-dihydropirolo[2,1-f] [1,2,4]triazynonu jako inhibitory fosfodiesterazy i ich zastosowania
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
WO2018078009A1 (en) 2016-10-29 2018-05-03 Bayer Pharma Aktiengesellschaft Amido-substituted cyclohexane derivatives
WO2018078005A1 (en) 2016-10-29 2018-05-03 Bayer Pharma Aktiengesellschaft Amido-substituted azaspiro derivatives as tankyrase inhibitors
WO2018087126A1 (en) 2016-11-09 2018-05-17 Bayer Pharma Aktiengesellschaft Amido-substituted cyclohexane derivatives as inhibitors of tankyrase
CN109180702B (zh) * 2018-10-29 2021-11-30 四川大学 一种噻吩并嘧啶酮化合物及其用途
CN111961058B (zh) * 2020-08-03 2022-12-16 天津全和诚科技有限责任公司 4-氨基-吡咯并三嗪衍生物及其制备方法和用途
AU2023249795A1 (en) 2022-04-08 2024-10-17 Shy Therapeutics, Llc Compounds that interact with ras superfamily proteins for treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
US6291455B1 (en) 1996-03-05 2001-09-18 Zeneca Limited 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
NZ522074A (en) 2000-05-31 2004-06-25 Astrazeneca Ab Indole derivatives with vascular damaging activity
CN1255392C (zh) 2000-07-07 2006-05-10 安吉奥金尼药品有限公司 作为血管生成抑制剂的秋水仙醇衍生物
IL153484A0 (en) 2000-07-07 2003-07-06 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
JP2006521398A (ja) 2003-03-28 2006-09-21 サイオス・インコーポレーテツド ＴＧＦβの二−環式ピリミジン阻害剤
WO2006035061A1 (en) 2004-09-30 2006-04-06 Tibotec Pharmaceuticals Ltd. Hcv inhibiting bi-cyclic pyrimidines
WO2008092861A1 (en) 2007-01-30 2008-08-07 Janssen Pharmaceutica N.V. Bicyclic derivatives as ep4 agonists
US8299256B2 (en) 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
CN101687874B (zh) * 2007-04-18 2013-01-30 百时美施贵宝公司 吡咯并三嗪激酶抑制剂

Also Published As

Publication number Publication date
HK1205740A1 (en) 2015-12-24
MX2014013090A (es) 2014-12-08
JP2015515961A (ja) 2015-06-04
MX357502B (es) 2018-07-12
EP2844659B1 (en) 2016-05-25
WO2013164061A8 (en) 2014-11-06
HRP20161033T1 (hr) 2016-10-21
RS55062B1 (sr) 2016-12-30
KR20150006873A (ko) 2015-01-19
EA027628B1 (ru) 2017-08-31
US9174995B2 (en) 2015-11-03
CN104271580A (zh) 2015-01-07
AU2013257018B2 (en) 2017-02-16
ES2587939T3 (es) 2016-10-27
US20150133453A1 (en) 2015-05-14
EP2844659A1 (en) 2015-03-11
SI2844659T1 (sl) 2016-10-28
AR090896A1 (es) 2014-12-17
CA2872334C (en) 2020-06-30
SG11201406997WA (en) 2014-11-27
PL2844659T3 (pl) 2016-11-30
PT2844659T (pt) 2016-08-31
JP6097820B2 (ja) 2017-03-15
ZA201408876B (en) 2017-06-28
CA2872334A1 (en) 2013-11-07
HUE028325T2 (en) 2016-12-28
WO2013164061A1 (en) 2013-11-07
AU2013257018A1 (en) 2014-12-18
IL235414A (en) 2017-11-30
CN104271580B (zh) 2017-02-22

Similar Documents

Publication Publication Date Title
EA201401212A1 (ru) Производные пирролотриазинона
EA201401062A1 (ru) Бициклические пиразиноновые производные
EA201400879A1 (ru) Производные тетрагидрохиназолинона в качестве ингибиторов tank и parp
EA201590230A1 (ru) Соединения пиразолопиримидина в качестве ингибиторов киназ
MX362939B (es) Derivados de (aza-)isoquinolinona.
MX362855B (es) Derivados de quinazolinona como inhidores poli (adp-ribosa) polimerasa (parp).
EA201400333A1 (ru) Бензонитрильные производные в качестве ингибиторов киназ
EA201301302A1 (ru) Производные пиридина и пиразина
EA201301301A1 (ru) Производные тиазола
NZ700928A (en) Dna-pk inhibitors
MX362215B (es) Derivados 2-aminopirido-[4,3-d]pirimidin-5-ona y su uso como inhibidores de wee-1.
EA201492216A1 (ru) Ингибиторы бромодомена и их применение
EA201491623A1 (ru) Замещенные пирролидин-2-карбоксамиды
EA201300610A1 (ru) Хиназолинкарбоксамидазетидины
MX359656B (es) Derivados de oxoquinazolinil-butanamida.
MX2016014436A (es) Derivados de heterociclil-butanamida.
MX2016001134A (es) Derivados 1,3-disustituidos de ciclopentano.
MX2016001536A (es) Derivados de urea de piperidinas.
EA201491026A1 (ru) Производные 3-фенилизохинолин-1(2h)-она в качестве ингибиторов parp-1
EA201200087A1 (ru) 2-карбоксамиды циклоаминомочевин, которые являются ингибиторами pi3k
MX2018005515A (es) Derivados de 1,4-dicarbonil-piperidilo.
MX364859B (es) Derivados de imidazopirazinona.
EA201590656A1 (ru) Азаиндолины
MX2015016760A (es) Derivados de ftalazina.
EA201101038A1 (ru) Производные пиридазинона

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU