EA202190452A1 - Ингибиторы cdk8/19 - Google Patents

Ингибиторы cdk8/19

Info

Publication number
EA202190452A1
EA202190452A1 EA202190452A EA202190452A EA202190452A1 EA 202190452 A1 EA202190452 A1 EA 202190452A1 EA 202190452 A EA202190452 A EA 202190452A EA 202190452 A EA202190452 A EA 202190452A EA 202190452 A1 EA202190452 A1 EA 202190452A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cdk8
inhibitors
compounds
pharmaceuticals
disorders
Prior art date
Application number
EA202190452A
Other languages
English (en)
Inventor
Алексей Леонидович МИНДИЧ
Анна Юрьевна ЧЕСТНОВА
Мария Андреевна КАСАТКИНА
Андрей Иванович АЛАФИНОВ
Алексей Сергеевич ГАВРИЛОВ
Антон Александрович ЕВДОКИМОВ
Лилиана Вячеславовна ЛЕНШМИДТ
Елена Александровна МАКСИМЕНКО
Мария Сергеевна МИШИНА
Сергей Александрович СИЛОНОВ
Евгений Юрьевич СМИРНОВ
Павел Андреевич ЯКОВЛЕВ
Дмитрий Валентинович МОРОЗОВ
Original Assignee
Закрытое Акционерное Общество "Биокад"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Закрытое Акционерное Общество "Биокад" filed Critical Закрытое Акционерное Общество "Биокад"
Publication of EA202190452A1 publication Critical patent/EA202190452A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к новым соединениям формулы Iкоторые обладают свойствами ингибитора CDK8/19, к фармацевтической композиции, содержащей данные соединения, и их применению в качестве фармацевтических препаратов для лечения заболеваний или нарушений.
EA202190452A 2018-08-03 2019-07-31 Ингибиторы cdk8/19 EA202190452A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2018128415A RU2761824C2 (ru) 2018-08-03 2018-08-03 Ингибиторы CDK8/19
PCT/RU2019/050123 WO2020027704A1 (ru) 2018-08-03 2019-07-31 Ингибиторы cdk8/19

Publications (1)

Publication Number Publication Date
EA202190452A1 true EA202190452A1 (ru) 2021-04-13

Family

ID=69231230

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190452A EA202190452A1 (ru) 2018-08-03 2019-07-31 Ингибиторы cdk8/19

Country Status (19)

Country Link
US (1) US11840531B2 (ru)
EP (1) EP3831829A4 (ru)
JP (1) JP7365396B2 (ru)
KR (1) KR102926889B1 (ru)
CN (1) CN113166140B (ru)
AR (1) AR115898A1 (ru)
AU (1) AU2019313199B2 (ru)
BR (1) BR112021001939A2 (ru)
CA (1) CA3108298A1 (ru)
CL (1) CL2021000282A1 (ru)
CO (1) CO2021001174A2 (ru)
EA (1) EA202190452A1 (ru)
MA (1) MA52375B2 (ru)
MX (1) MX2021001335A (ru)
PE (1) PE20210416A1 (ru)
PH (1) PH12021550258A1 (ru)
RU (1) RU2761824C2 (ru)
TW (1) TWI839374B (ru)
WO (1) WO2020027704A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3189027A1 (en) 2020-07-11 2022-01-20 Pfizer Inc. Antiviral heteroaryl ketone derivatives
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
CN120265622A (zh) * 2022-11-21 2025-07-04 上海齐鲁制药研究中心有限公司 Cdk抑制剂

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200808739A (en) * 2006-04-06 2008-02-16 Novartis Vaccines & Diagnostic Quinazolines for PDK1 inhibition
MX2010006244A (es) * 2007-12-06 2010-12-02 Schering Corp Moduladores de gamma secretasa.
EP2630122B1 (en) * 2010-10-18 2016-11-30 RaQualia Pharma Inc Arylamide derivatives as ttx-s blockers
TWI529171B (zh) * 2013-07-29 2016-04-11 赫孚孟拉羅股份公司 １，７－萘啶衍生物
WO2016009076A1 (en) 2014-07-17 2016-01-21 Merck Patent Gmbh Novel naphthryidines and isoquinolines and their use as cdk8/19 inhibitors
WO2017094026A1 (en) * 2015-11-30 2017-06-08 Council Of Scientific & Industrial Research 3-pyrimidinyl pyrrolo [2,3-b] pyridine as new anticancer agents and the process for the preparation thereof
WO2017202719A1 (en) * 2016-05-23 2017-11-30 Boehringer Ingelheim International Gmbh New phenylpyrazolylacetamide compounds and derivatives as cdk8/cdk19 inhibitors

Also Published As

Publication number Publication date
CN113166140A (zh) 2021-07-23
AU2019313199A1 (en) 2021-03-11
CN113166140B (zh) 2024-06-14
US11840531B2 (en) 2023-12-12
RU2018128415A3 (ru) 2021-03-30
CA3108298A1 (en) 2020-02-06
BR112021001939A2 (pt) 2021-04-27
EP3831829A1 (en) 2021-06-09
JP2021533143A (ja) 2021-12-02
KR102926889B1 (ko) 2026-02-19
MA52375A1 (fr) 2021-12-31
TW202012406A (zh) 2020-04-01
RU2018128415A (ru) 2020-02-04
PE20210416A1 (es) 2021-03-04
WO2020027704A1 (ru) 2020-02-06
RU2761824C2 (ru) 2021-12-13
AU2019313199B2 (en) 2023-07-06
KR20210040416A (ko) 2021-04-13
MX2021001335A (es) 2021-04-12
JP7365396B2 (ja) 2023-10-19
AR115898A1 (es) 2021-03-10
TWI839374B (zh) 2024-04-21
CO2021001174A2 (es) 2021-02-26
MA52375B2 (fr) 2023-02-28
PH12021550258A1 (en) 2021-10-11
US20210246138A1 (en) 2021-08-12
CL2021000282A1 (es) 2021-08-13
EP3831829A4 (en) 2022-04-20

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