EA202190832A1 - Способы получения соединений пиразола - Google Patents
Способы получения соединений пиразолаInfo
- Publication number
- EA202190832A1 EA202190832A1 EA202190832A EA202190832A EA202190832A1 EA 202190832 A1 EA202190832 A1 EA 202190832A1 EA 202190832 A EA202190832 A EA 202190832A EA 202190832 A EA202190832 A EA 202190832A EA 202190832 A1 EA202190832 A1 EA 202190832A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- preparation
- methods
- compounds
- substituted pyrazole
- processes
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 4
- NOIXNOMHHWGUTG-UHFFFAOYSA-N 2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline Chemical compound C=1C=C(OCC=2N=C3C=CC=CC3=CC=2)C=CC=1C1=NN(CC(F)(F)F)C=C1C1=CC=NC=C1 NOIXNOMHHWGUTG-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- OFUOCIUIWKDKPA-UHFFFAOYSA-N 3-[4-[(7-hydroxy-6-methyl-2,3-dihydro-1h-inden-4-yl)methyl]-3,5-dimethylpyrazol-1-yl]propanoic acid Chemical compound CC1=NN(CCC(O)=O)C(C)=C1CC1=CC(C)=C(O)C2=C1CCC2 OFUOCIUIWKDKPA-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000007787 solid Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 210000001685 thyroid gland Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Abstract
Изобретение относится к способам получения соединений на основе замещенного пиразола при помощи новых промежуточных соединений и уникальных процессов получения таких промежуточных соединений, что облегчает синтез готового продукта при помощи коммерчески подходящего пути синтеза. Настоящее изобретение также направлено на новые способы получения тиреоидных соединений на основе замещенного пиразола, а также на твердые формы 3-{4-[(7-гидрокси-6-метилиндан-4-ил)метил]-3,5-диметил-1H-пиразол-1-ил}пропановой кислоты, ее фармацевтические композиции и способы их получения.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201821035741 | 2018-09-22 | ||
| PCT/IB2019/058005 WO2020058945A1 (en) | 2018-09-22 | 2019-09-21 | Methods of producing pyrazole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202190832A1 true EA202190832A1 (ru) | 2021-08-18 |
Family
ID=69888611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202190832A EA202190832A1 (ru) | 2018-09-22 | 2019-09-21 | Способы получения соединений пиразола |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11560357B2 (ru) |
| EP (1) | EP3853209A4 (ru) |
| JP (1) | JP2022501386A (ru) |
| KR (1) | KR20210064310A (ru) |
| CN (1) | CN113166069A (ru) |
| AU (1) | AU2019343529A1 (ru) |
| BR (1) | BR112021005274A2 (ru) |
| CA (1) | CA3113743A1 (ru) |
| EA (1) | EA202190832A1 (ru) |
| IL (1) | IL281431A (ru) |
| MX (1) | MX2021003282A (ru) |
| PH (1) | PH12021550647A1 (ru) |
| SG (1) | SG11202102332QA (ru) |
| WO (1) | WO2020058945A1 (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023047203A1 (en) | 2021-09-25 | 2023-03-30 | Torrent Pharmaceuticals Ltd | Combination of omzotirome and antidiabetic agent, antihypertensive agent or anti-dyslipidemic agent |
| CN115160210B (zh) * | 2022-08-01 | 2023-10-24 | 上海巽田科技股份有限公司 | 一种合成杂双环类化合物的方法 |
| WO2025049339A2 (en) * | 2023-08-25 | 2025-03-06 | Nuvation Bio Inc. | Crystalline forms of a bet inhibitor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU688499A1 (ru) * | 1978-04-06 | 1979-09-30 | Институт Органической Химии Ан Армянской Сср | Производные пиразол-1-пропионовой кислоты в качестве отвердителей эпоксидных смол |
| CA2545821C (en) | 2003-12-22 | 2010-09-21 | Basilea Pharmaceutica Ag | Aroylfuranes and aroylthiophenes |
| ATE478053T1 (de) | 2007-06-06 | 2010-09-15 | Torrent Pharmaceuticals Ltd | Neuartige verbindungen |
| CN101891618B (zh) * | 2010-06-23 | 2012-10-31 | 厦门大学 | 2-[(2,3,4-三烷氧基-6-酰基)苯基]乙酸酯及其制备方法与应用 |
| CN102351702B (zh) * | 2011-08-18 | 2014-08-13 | 厦门大学 | 降血糖药物分子tapa的合成方法 |
-
2019
- 2019-09-21 EA EA202190832A patent/EA202190832A1/ru unknown
- 2019-09-21 CN CN201980076920.2A patent/CN113166069A/zh active Pending
- 2019-09-21 KR KR1020217012058A patent/KR20210064310A/ko not_active Ceased
- 2019-09-21 US US17/277,036 patent/US11560357B2/en active Active
- 2019-09-21 CA CA3113743A patent/CA3113743A1/en active Pending
- 2019-09-21 EP EP19862401.7A patent/EP3853209A4/en not_active Withdrawn
- 2019-09-21 JP JP2021516379A patent/JP2022501386A/ja active Pending
- 2019-09-21 MX MX2021003282A patent/MX2021003282A/es unknown
- 2019-09-21 AU AU2019343529A patent/AU2019343529A1/en not_active Abandoned
- 2019-09-21 SG SG11202102332QA patent/SG11202102332QA/en unknown
- 2019-09-21 BR BR112021005274-7A patent/BR112021005274A2/pt not_active IP Right Cessation
- 2019-09-21 WO PCT/IB2019/058005 patent/WO2020058945A1/en not_active Ceased
-
2021
- 2021-03-11 IL IL281431A patent/IL281431A/en unknown
- 2021-03-20 PH PH12021550647A patent/PH12021550647A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021005274A2 (pt) | 2021-06-15 |
| EP3853209A1 (en) | 2021-07-28 |
| EP3853209A4 (en) | 2022-09-14 |
| PH12021550647A1 (en) | 2021-10-11 |
| SG11202102332QA (en) | 2021-04-29 |
| KR20210064310A (ko) | 2021-06-02 |
| WO2020058945A1 (en) | 2020-03-26 |
| CA3113743A1 (en) | 2020-03-26 |
| CN113166069A (zh) | 2021-07-23 |
| AU2019343529A1 (en) | 2021-04-15 |
| JP2022501386A (ja) | 2022-01-06 |
| IL281431A (en) | 2021-04-29 |
| MX2021003282A (es) | 2021-06-08 |
| US20220033358A1 (en) | 2022-02-03 |
| US11560357B2 (en) | 2023-01-24 |
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