ECSP003310A - PROCEDURE FOR THE PREPARATION OF L-PHENYLEFRINE HYDROCHLORIDE - Google Patents
PROCEDURE FOR THE PREPARATION OF L-PHENYLEFRINE HYDROCHLORIDEInfo
- Publication number
- ECSP003310A ECSP003310A ECSP003310A ECSP003310A EC SP003310 A ECSP003310 A EC SP003310A EC SP003310 A ECSP003310 A EC SP003310A EC SP003310 A ECSP003310 A EC SP003310A
- Authority
- EC
- Ecuador
- Prior art keywords
- hydrochloride
- preparation
- phenylefrine
- procedure
- methyl
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 238000009876 asymmetric hydrogenation reaction Methods 0.000 abstract 1
- -1 dicyclohexyl-phosphino Chemical group 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960001802 phenylephrine Drugs 0.000 abstract 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
El presente invento se refiere a un procedimiento mejorado de preparación de hidrocloruro de L-fenilefrina 3 a escala industrial mediando aplicación de una hidrogenación asimétrica como etapa clave y de una sucesión especial de etapas consecutivas, empleándose como catalizador una mezcla de [Rh(COD)Cl]2 y un ligando bidentado de fosfina guiral, tal como (2R,4R)-4 (diciclohexil-fosfino)-2-(difenilfosfofino-metil)-N-metil-aminocarbonil-pirrolidina como sistema de catalizadores.The present invention relates to an improved process for the preparation of L-phenylephrine 3 hydrochloride on an industrial scale using an asymmetric hydrogenation as a key step and a special succession of consecutive steps, using as a catalyst a mixture of [Rh (COD) Cl] 2 and a guiral phosphine bidentate ligand, such as (2R, 4R) -4 (dicyclohexyl-phosphino) -2- (diphenylphosphophino-methyl) -N-methyl-aminocarbonyl-pyrrolidine as the catalyst system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003310 ECSP003310A (en) | 2000-01-06 | 2000-01-06 | PROCEDURE FOR THE PREPARATION OF L-PHENYLEFRINE HYDROCHLORIDE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003310 ECSP003310A (en) | 2000-01-06 | 2000-01-06 | PROCEDURE FOR THE PREPARATION OF L-PHENYLEFRINE HYDROCHLORIDE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003310A true ECSP003310A (en) | 2000-09-22 |
Family
ID=42040941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003310 ECSP003310A (en) | 2000-01-06 | 2000-01-06 | PROCEDURE FOR THE PREPARATION OF L-PHENYLEFRINE HYDROCHLORIDE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003310A (en) |
-
2000
- 2000-01-06 EC ECSP003310 patent/ECSP003310A/en unknown
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