ECSP003322A - COMPLEJO DEL INHIBIDOR DE RAS- FARNESIL TRANSFERASA Y SULFOBUTILETER -7-ß- CICLODEXTRINA O 2- HIDROXIPROPIL - ß - CICLODEXTRINA Y METODO - Google Patents
COMPLEJO DEL INHIBIDOR DE RAS- FARNESIL TRANSFERASA Y SULFOBUTILETER -7-ß- CICLODEXTRINA O 2- HIDROXIPROPIL - ß - CICLODEXTRINA Y METODOInfo
- Publication number
- ECSP003322A ECSP003322A ECSP003322A ECSP003322A EC SP003322 A ECSP003322 A EC SP003322A EC SP003322 A ECSP003322 A EC SP003322A EC SP003322 A ECSP003322 A EC SP003322A
- Authority
- EC
- Ecuador
- Prior art keywords
- cyclodextrin
- sulfobutileter
- hydroxipropil
- ras
- rasfarnesyltransferase
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 239000001116 FEMA 4028 Substances 0.000 title 2
- 229960004853 betadex Drugs 0.000 title 2
- 102000004357 Transferases Human genes 0.000 title 1
- 108090000992 Transferases Proteins 0.000 title 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 title 1
- 229950008696 farnesil Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 phenyl pyridyl Chemical group 0.000 abstract 2
- DCQLZTSRKLWEAB-UHFFFAOYSA-N ac1ndudu Chemical compound O1C(C(C2OCC(C)O)OCC(C)O)C(COCC(C)O)OC2OC(C(C2OCC(C)O)OCC(C)O)C(COCC(C)O)OC2OC(C(C2OCC(C)O)OCC(C)O)C(COCC(C)O)OC2OC(C(C2OCC(C)O)OCC(C)O)C(COCC(C)O)OC2OC(C(OCC(C)O)C2OCC(C)O)C(COCC(O)C)OC2OC(C(C2OCC(C)O)OCC(C)O)C(COCC(C)O)OC2OC2C(OCC(C)O)C(OCC(C)O)C1OC2COCC(C)O DCQLZTSRKLWEAB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se proporciona un complejo del inhibidor de la rasfarnesiltransferasa formado del inhibidor de la rasfarnesiltransferasa o una sal farmacéuticamente aceptable del mismo, de la fórmula I (gráfico), en donde n es 0 o 1, R1 se selcciona de Cl, Br, fenilo piridilo o ciano; R2 es aralquilo; R3 se selecciona de alquilo inferior, arilo o arilo sustituido o heterociclo; Z1 se selcciona de CO, SO2, CO2 o SO2NR5, R5 se selecciona de hidrógeno, alquilo inferior o alquilo sustituido; y sulfobutiléter-7-B-ciclodextrina o 2-hidroxipropil-B-ciclodextrina. El complejo tiene inesperadamente alta solubilidad acuosa del inhibidor de la rasfarnesiltransferasa son útiles como agentes anti-tumorales.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003322 ECSP003322A (es) | 2000-01-19 | 2000-01-19 | COMPLEJO DEL INHIBIDOR DE RAS- FARNESIL TRANSFERASA Y SULFOBUTILETER -7-ß- CICLODEXTRINA O 2- HIDROXIPROPIL - ß - CICLODEXTRINA Y METODO |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003322 ECSP003322A (es) | 2000-01-19 | 2000-01-19 | COMPLEJO DEL INHIBIDOR DE RAS- FARNESIL TRANSFERASA Y SULFOBUTILETER -7-ß- CICLODEXTRINA O 2- HIDROXIPROPIL - ß - CICLODEXTRINA Y METODO |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003322A true ECSP003322A (es) | 2000-02-24 |
Family
ID=42040953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003322 ECSP003322A (es) | 2000-01-19 | 2000-01-19 | COMPLEJO DEL INHIBIDOR DE RAS- FARNESIL TRANSFERASA Y SULFOBUTILETER -7-ß- CICLODEXTRINA O 2- HIDROXIPROPIL - ß - CICLODEXTRINA Y METODO |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003322A (es) |
-
2000
- 2000-01-19 EC ECSP003322 patent/ECSP003322A/es unknown
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| ECSP003322A (es) | COMPLEJO DEL INHIBIDOR DE RAS- FARNESIL TRANSFERASA Y SULFOBUTILETER -7-ß- CICLODEXTRINA O 2- HIDROXIPROPIL - ß - CICLODEXTRINA Y METODO |