ECSP003381A - DERIVATIVES OF BIPHENIL - Google Patents

DERIVATIVES OF BIPHENIL

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Publication number
ECSP003381A
ECSP003381A ECSP003381A ECSP003381A EC SP003381 A ECSP003381 A EC SP003381A EC SP003381 A ECSP003381 A EC SP003381A EC SP003381 A ECSP003381 A EC SP003381A
Authority
EC
Ecuador
Prior art keywords
hydrogen
lower alkyl
halogen
trifluoromethyl
amino
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Guido Galley
Thierry Godel
Walter Hunkeler
Heinz Stadler
Michael Bos
Torsten Hoffmann
Patrick Schnider
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP003381 priority Critical patent/ECSP003381A/en
Publication of ECSP003381A publication Critical patent/ECSP003381A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a compuestos de la fórmula general (gráfico), en donde R es hidrógeno, alquilo inferior, alcoxi inferior, halógeno, amino, -N(R6)2 ó trifluorometilo; R1 es hidrógeno, alcoxi inferior o halógeno; R y R1 pueden ser conjuntamente -CH=CH-CH=CH-; R2 es halógeno, alquilo inferior o trifluorometilo; R3 es hidrógeno o alquilo inferior; R4 es hidrógeno o una amina terciaria cíclica, sustituida opcionalmente por alquilo inferior; R5 es hidrógeno, nitro, amino ó -N(R6)2; R6 es hidrógeno o alquilo inferior; X es -C(O)N(R6)-, -(CH2)n O-, -(CH2)nN(R6)-, -N(R6)C(O)- ó -N(R6)(CH2)n-; y ES 1-2; y sales derivadas de una adición ácida farmacéuticamente aceptables. Los compuestos de la fórmula I se pueden usar para el tratamiento de enfermedades relacionadas con el receptor de NK-1.The invention relates to compounds of the general formula (graph), wherein R is hydrogen, lower alkyl, lower alkoxy, halogen, amino, -N (R6) 2 or trifluoromethyl; R1 is hydrogen, lower alkoxy or halogen; R and R1 can be together -CH = CH-CH = CH-; R2 is halogen, lower alkyl, or trifluoromethyl; R3 is hydrogen or lower alkyl; R4 is hydrogen or a cyclic tertiary amine, optionally substituted by lower alkyl; R5 is hydrogen, nitro, amino or -N (R6) 2; R6 is hydrogen or lower alkyl; X is -C (O) N (R6) -, - (CH2) n O-, - (CH2) nN (R6) -, -N (R6) C (O) - or -N (R6) (CH2) n-; and IS 1-2; and salts derived from a pharmaceutically acceptable acid addition. The compounds of formula I can be used for the treatment of NK-1 receptor related diseases.

ECSP003381 2000-03-09 2000-03-09 DERIVATIVES OF BIPHENIL ECSP003381A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP003381 ECSP003381A (en) 2000-03-09 2000-03-09 DERIVATIVES OF BIPHENIL

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP003381 ECSP003381A (en) 2000-03-09 2000-03-09 DERIVATIVES OF BIPHENIL

Publications (1)

Publication Number Publication Date
ECSP003381A true ECSP003381A (en) 2000-10-24

Family

ID=42041011

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP003381 ECSP003381A (en) 2000-03-09 2000-03-09 DERIVATIVES OF BIPHENIL

Country Status (1)

Country Link
EC (1) ECSP003381A (en)

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