ECSP003383A - PROTEIN TO BLOCK THE PLAQUETARY ADHERENCE - Google Patents
PROTEIN TO BLOCK THE PLAQUETARY ADHERENCEInfo
- Publication number
- ECSP003383A ECSP003383A ECSP003383A ECSP003383A EC SP003383 A ECSP003383 A EC SP003383A EC SP003383 A ECSP003383 A EC SP003383A EC SP003383 A ECSP003383 A EC SP003383A
- Authority
- EC
- Ecuador
- Prior art keywords
- protein
- collagen
- natural
- cells
- medicinalis
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 102000008186 Collagen Human genes 0.000 abstract 4
- 108010035532 Collagen Proteins 0.000 abstract 4
- 229920001436 collagen Polymers 0.000 abstract 4
- 235000018102 proteins Nutrition 0.000 abstract 4
- 241000237902 Hirudo medicinalis Species 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 230000020411 cell activation Effects 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 150000001945 cysteines Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 208000019622 heart disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se describe una proteína natural aislada de la saliva de la sanguijuela medicinal Hirudo medicinalis que se une fuertemente al colágeno, actuando de esta manera con un inhibidor de la adherencia natural de las plaquetas al colágeno. La proteína tiene un peso molecular de aproximadamente 12000, un punto isoeléctrico ácido y contiene seis cisteínas. La proteína fue secuenciada y el gen fue clonado a partir de la biblioteca de ADNc de H. Medicinalis. También se dan a conocer procediemientos para producir tal polipéptidos por medio de técnicas recombinantes. Tanto las proteínas naturales como las quiméricas son inhibidores potentes de la adherencia de plaquetas dependientes del colágeno, y por tanto, pueden ser utilizadas para el tratamiento terapéutico de diversas condiciones relacionadas con la enfermedad cardiaca y las enfermedades del sistema circulatorio. Además, la proteína también es apropiada para recubrir superficies naturales o artificiales de colágeno con el fin de volverlas no adhesivas para las células y de esta manera prevenir la activación de células.A natural protein isolated from the saliva of the medicinal leech Hirudo medicinalis that binds strongly to collagen is described, thus acting with an inhibitor of the natural adhesion of platelets to collagen. The protein has a molecular weight of approximately 12,000, an acid isoelectric point and contains six cysteines. The protein was sequenced and the gene was cloned from the H. Medicinalis cDNA library. Procedures for producing such polypeptides by recombinant techniques are also disclosed. Both natural and chimeric proteins are potent inhibitors of collagen-dependent platelet adhesion, and therefore, can be used for the therapeutic treatment of various conditions related to heart disease and circulatory system diseases. In addition, the protein is also suitable for coating natural or artificial collagen surfaces in order to render them non-adhesive to the cells and thus prevent the activation of cells.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003383 ECSP003383A (en) | 2000-03-15 | 2000-03-15 | PROTEIN TO BLOCK THE PLAQUETARY ADHERENCE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003383 ECSP003383A (en) | 2000-03-15 | 2000-03-15 | PROTEIN TO BLOCK THE PLAQUETARY ADHERENCE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003383A true ECSP003383A (en) | 2001-03-22 |
Family
ID=42041013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003383 ECSP003383A (en) | 2000-03-15 | 2000-03-15 | PROTEIN TO BLOCK THE PLAQUETARY ADHERENCE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003383A (en) |
-
2000
- 2000-03-15 EC ECSP003383 patent/ECSP003383A/en unknown
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