ECSP003402A - INHIBITORS OF SORBITOL DEHYDROGENASE - Google Patents
INHIBITORS OF SORBITOL DEHYDROGENASEInfo
- Publication number
- ECSP003402A ECSP003402A ECSP003402A ECSP003402A EC SP003402 A ECSP003402 A EC SP003402A EC SP003402 A ECSP003402 A EC SP003402A EC SP003402 A ECSP003402 A EC SP003402A
- Authority
- EC
- Ecuador
- Prior art keywords
- diabetic
- relates
- formula
- methods
- compounds
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108010009384 L-Iditol 2-Dehydrogenase Proteins 0.000 title 1
- 102100026974 Sorbitol dehydrogenase Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 208000002249 Diabetes Complications Diseases 0.000 abstract 2
- 206010012655 Diabetic complications Diseases 0.000 abstract 2
- 206010063547 Diabetic macroangiopathy Diseases 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229940118148 Aldose reductase inhibitor Drugs 0.000 abstract 1
- 208000031229 Cardiomyopathies Diseases 0.000 abstract 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 abstract 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102100030980 Sodium/hydrogen exchanger 1 Human genes 0.000 abstract 1
- 229940123659 Sorbitol dehydrogenase inhibitor Drugs 0.000 abstract 1
- 239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000033679 diabetic kidney disease Diseases 0.000 abstract 1
- MNQZXJOMYWMBOU-UHFFFAOYSA-N glyceraldehyde Chemical compound OCC(O)C=O MNQZXJOMYWMBOU-UHFFFAOYSA-N 0.000 abstract 1
- 108010093115 growth factor-activatable Na-H exchanger NHE-1 Proteins 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se refiere a compuestos inhibidores de la sorbitol deshidrogenasa de la fórmula I (gráfico), em la que R1,R2,R3 son como se ha definido en la memoria descriptiva. Esta invención también se refiere a composiciones farmacéuticas que contienen estos compuestos y a procedimientos de tratamiento o prevención de las complicaciones diabéticas, las macroangiopatía diabética y la cardiomipatía diabética particularmente la neuropatía diabética, la nefropatía diabética, la macroangiopatía diabética, mediante la administración de tales compuestos a un mamifero que sufre diabetes por lo tanto, puede desarrollar tales complicaciones. Esta invención también se refiere a composiciones farmacéuticas que comprenden una combinación de un compuesto de la fórmula I de esta invención con un inhibidor de la aldosa reductasa y a procedimientos de tratamiento o prevención decomplicaciones diabéticas con tales composiciones. Esta invención también se refiere a composiciones farmacéuticas que comprenden una combionación de un compuesto de fórmula I de esta invención con un inhibidor de NHE-1 y a procedimientos de tratamiento de cardiomiopatias y otros problemas ralecionados con el corazón con tales composiciones. Esta invención también se refiere a ciertos intermedios usados en la sintesis de los compuestos de fórmula I y a procedimientos para preparar esos intermedios.The invention relates to sorbitol dehydrogenase inhibitor compounds of the formula I (graph), in which R1, R2, R3 are as defined in the specification. This invention also relates to pharmaceutical compositions containing these compounds and to methods of treatment or prevention of diabetic complications, diabetic macroangiopathy and diabetic cardiomipathy particularly diabetic neuropathy, diabetic nephropathy, diabetic macroangiopathy, by administering such compounds to A mammal who suffers from diabetes can therefore develop such complications. This invention also relates to pharmaceutical compositions comprising a combination of a compound of the formula I of this invention with an aldose reductase inhibitor and methods of treating or preventing diabetic complications with such compositions. This invention also relates to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and methods of treating cardiomyopathy and other heart-related problems with such compositions. This invention also relates to certain intermediates used in the synthesis of the compounds of formula I and to methods for preparing those intermediates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003402 ECSP003402A (en) | 2000-03-27 | 2000-03-27 | INHIBITORS OF SORBITOL DEHYDROGENASE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003402 ECSP003402A (en) | 2000-03-27 | 2000-03-27 | INHIBITORS OF SORBITOL DEHYDROGENASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003402A true ECSP003402A (en) | 2001-10-25 |
Family
ID=42041032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003402 ECSP003402A (en) | 2000-03-27 | 2000-03-27 | INHIBITORS OF SORBITOL DEHYDROGENASE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003402A (en) |
-
2000
- 2000-03-27 EC ECSP003402 patent/ECSP003402A/en unknown
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