ECSP003408A - Biphenyl aPz inhibitors containing heterocyclic compounds and method - Google Patents
Biphenyl aPz inhibitors containing heterocyclic compounds and methodInfo
- Publication number
- ECSP003408A ECSP003408A ECSP003408A ECSP003408A EC SP003408 A ECSP003408 A EC SP003408A EC SP003408 A ECSP003408 A EC SP003408A EC SP003408 A ECSP003408 A EC SP003408A
- Authority
- EC
- Ecuador
- Prior art keywords
- apz
- biphenyl
- containing heterocyclic
- heterocyclic compounds
- inhibitors containing
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title 2
- 235000010290 biphenyl Nutrition 0.000 title 1
- 239000004305 biphenyl Substances 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 229940125708 antidiabetic agent Drugs 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960004580 glibenclamide Drugs 0.000 abstract 1
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 abstract 1
- 229960003105 metformin Drugs 0.000 abstract 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 abstract 1
- 229960001641 troglitazone Drugs 0.000 abstract 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se proporciona un compuesto que inhibe a P2 que tiene la fórmula (gráfico), en donde R1, R2, R3, R4, X-X y (gráfico), son como se describen en la presente. También se proporciona un método para tratar la diabetes y enfermedades relacionadas, especialmenrte diabets tipo II, que emplean estos inhibidores de aP2 o una combinación de este inhibidor de aP2 y otro agente antidiabético tal como metformina, gliburido, troglitazona y/o insulina.A P2-inhibiting compound is provided having the formula (graph), wherein R1, R2, R3, R4, X-X and (graph), are as described herein. Also provided is a method of treating diabetes and related diseases, especially type II diabets, that employ these aP2 inhibitors or a combination of this aP2 inhibitor and another antidiabetic agent such as metformin, glyburide, troglitazone, and / or insulin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003408 ECSP003408A (en) | 2000-03-30 | 2000-03-30 | Biphenyl aPz inhibitors containing heterocyclic compounds and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003408 ECSP003408A (en) | 2000-03-30 | 2000-03-30 | Biphenyl aPz inhibitors containing heterocyclic compounds and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003408A true ECSP003408A (en) | 2000-05-25 |
Family
ID=42041038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003408 ECSP003408A (en) | 2000-03-30 | 2000-03-30 | Biphenyl aPz inhibitors containing heterocyclic compounds and method |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003408A (en) |
-
2000
- 2000-03-30 EC ECSP003408 patent/ECSP003408A/en unknown
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