ECSP003442A - SYNERGETIC EFFECTS OF AMLODIPINE AND ATORVASTATINE OR METABOLITE OF ATORVASTATINE AS A BASIS FOR COMBINATION THERAPY - Google Patents
SYNERGETIC EFFECTS OF AMLODIPINE AND ATORVASTATINE OR METABOLITE OF ATORVASTATINE AS A BASIS FOR COMBINATION THERAPYInfo
- Publication number
- ECSP003442A ECSP003442A ECSP003442A ECSP003442A EC SP003442 A ECSP003442 A EC SP003442A EC SP003442 A ECSP003442 A EC SP003442A EC SP003442 A ECSP003442 A EC SP003442A
- Authority
- EC
- Ecuador
- Prior art keywords
- amlodipine
- combination
- atorvastatine
- basis
- combination therapy
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La combinación de amlodipina sea con atorvastatina o metabolito de atorvastatina muestra un efecto antioxidante sinérgico en la peroxidación de lípido de lipoproteínas humanas de baja densidad y vesiculas de membrana enriquecidas con ácidos grasos polinsaturados. La inhibición del daño oxi-radical por esta combinación de droga se observó a niveles terapéuticos de una manera que no puede ser reproducida por la combinación de amlodipina con otras estatinas o el antioxidante natural, Vitamina E. La base para esta actividad potente se atribuye a las estructuras químicas de estos compuestos y a sus interacciones moleculares con las moléculas de fosdolípidos, como se determina por análisis de difracción de rayos X. Esta terapia de combinación se puede usar para tratar desórdenes cardiovasculares, especialmente, enfermedad coronaria arterial, aumentado la resistencia de las lipoproteínas de baja densidad y las membranbas de célula vascular contra la modificación oxidativa.The combination of amlodipine with either atorvastatin or the atorvastatin metabolite shows a synergistic antioxidant effect on lipid peroxidation of low-density human lipoproteins and membrane vesicles enriched with polyunsaturated fatty acids. Inhibition of oxy-radical damage by this drug combination was observed at therapeutic levels in a way that cannot be reproduced by the combination of amlodipine with other statins or the natural antioxidant, Vitamin E. The basis for this potent activity is attributed to the chemical structures of these compounds and their molecular interactions with phosdolipid molecules, as determined by X-ray diffraction analysis. This combination therapy can be used to treat cardiovascular disorders, especially coronary artery disease, increasing resistance to low-density lipoproteins and vascular cell membranes against oxidative modification.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003442 ECSP003442A (en) | 2000-04-27 | 2000-04-27 | SYNERGETIC EFFECTS OF AMLODIPINE AND ATORVASTATINE OR METABOLITE OF ATORVASTATINE AS A BASIS FOR COMBINATION THERAPY |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003442 ECSP003442A (en) | 2000-04-27 | 2000-04-27 | SYNERGETIC EFFECTS OF AMLODIPINE AND ATORVASTATINE OR METABOLITE OF ATORVASTATINE AS A BASIS FOR COMBINATION THERAPY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003442A true ECSP003442A (en) | 2000-08-18 |
Family
ID=42041070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003442 ECSP003442A (en) | 2000-04-27 | 2000-04-27 | SYNERGETIC EFFECTS OF AMLODIPINE AND ATORVASTATINE OR METABOLITE OF ATORVASTATINE AS A BASIS FOR COMBINATION THERAPY |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003442A (en) |
-
2000
- 2000-04-27 EC ECSP003442 patent/ECSP003442A/en unknown
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