ECSP003475A - PIRROLOTRIAZINE KINASE INHIBITORS - Google Patents
PIRROLOTRIAZINE KINASE INHIBITORSInfo
- Publication number
- ECSP003475A ECSP003475A ECSP003475A ECSP003475A EC SP003475 A ECSP003475 A EC SP003475A EC SP003475 A ECSP003475 A EC SP003475A EC SP003475 A ECSP003475 A EC SP003475A
- Authority
- EC
- Ecuador
- Prior art keywords
- formula
- compounds
- pirrolotriazine
- kinase inhibitors
- useful
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108010009202 Growth Factor Receptors Proteins 0.000 abstract 2
- 102000009465 Growth Factor Receptors Human genes 0.000 abstract 2
- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 abstract 1
- 101100123850 Caenorhabditis elegans her-1 gene Proteins 0.000 abstract 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 abstract 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 abstract 1
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 abstract 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 abstract 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención proporciona compuestos de fórmula I (gráfico), y sales farmacéuticamente aceptables de los mismos. Los compuestos de fórmula I inhiben la actividad de la tirosina cinasa de los receptores del factor del crecimiento, tales como el VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, haciéndolos por lo tanto útiles como agentes anticancerosos. Los compuestos de fórmula I también son útiles para el tratamiento de otras enfermedades asociadas con las rutas de transducción de señales que funcionan a través de los receptores del factor de crecimiento.The present invention provides compounds of formula I (graph), and pharmaceutically acceptable salts thereof. The compounds of formula I inhibit the activity of growth factor receptor tyrosine kinase, such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anticancer agents. The compounds of formula I are also useful for the treatment of other diseases associated with signal transduction pathways that function through growth factor receptors.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003475 ECSP003475A (en) | 2000-05-17 | 2000-05-17 | PIRROLOTRIAZINE KINASE INHIBITORS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003475 ECSP003475A (en) | 2000-05-17 | 2000-05-17 | PIRROLOTRIAZINE KINASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003475A true ECSP003475A (en) | 2000-06-19 |
Family
ID=42041101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003475 ECSP003475A (en) | 2000-05-17 | 2000-05-17 | PIRROLOTRIAZINE KINASE INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003475A (en) |
-
2000
- 2000-05-17 EC ECSP003475 patent/ECSP003475A/en unknown
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