ECSP003510A - POLYMORPHOS OF A AZOBICICLO CITRATE (2,2,2) OCT - 3 - CRYSTALLINE ILAMINE AND ITS PHARMACEUTICAL COMPOSITIONS - Google Patents

POLYMORPHOS OF A AZOBICICLO CITRATE (2,2,2) OCT - 3 - CRYSTALLINE ILAMINE AND ITS PHARMACEUTICAL COMPOSITIONS

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Publication number
ECSP003510A
ECSP003510A ECSP003510A ECSP003510A EC SP003510 A ECSP003510 A EC SP003510A EC SP003510 A ECSP003510 A EC SP003510A EC SP003510 A ECSP003510 A EC SP003510A
Authority
EC
Ecuador
Prior art keywords
oct
crystalline
polymorphos
azobiciclo
ilamine
Prior art date
Application number
Other languages
Spanish (es)
Inventor
George Joseph Quallich
Lewin Theophilus Wint
Peter Robert Rose
Stephen Sargent Massett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP003510 priority Critical patent/ECSP003510A/en
Publication of ECSP003510A publication Critical patent/ECSP003510A/en

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dos formas polimórficas cristalinas de citrato de (2-benzhidril-1-azo-biciclo(2.2.2)oct-3-il)-(5-isopropil-2-metoxibencil)amina monohidrato (los monohidratos) son la forma A y la forma B. La composición farmacéutica que contiene al menos uno de estos polimorfos tiene una estabilidad ventajosa para la formulación para el tratamiento de émesis aguda en pacientes que reciben quimioterapia. La administarción de esta composición farmacéutica es convencionalmente oral, mediante preferiblemente comprimidos o cápsulas e intravenosa. Se describe también un procedimiento de obtención de las formas A y B.Two crystalline polymorphic forms of (2-benzhidril-1-azo-bicyclo (2.2.2) oct-3-yl) - (5-isopropyl-2-methoxybenzyl) amine monohydrate (the monohydrates) are Form A and Form B. The pharmaceutical composition containing at least one of these polymorphs has an advantageous stability for the formulation for the treatment of acute emesis in patients receiving chemotherapy. Administration of this pharmaceutical composition is conventionally oral, preferably by tablet or capsule, and intravenous. A procedure for obtaining forms A and B is also described.

ECSP003510 2000-06-01 2000-06-01 POLYMORPHOS OF A AZOBICICLO CITRATE (2,2,2) OCT - 3 - CRYSTALLINE ILAMINE AND ITS PHARMACEUTICAL COMPOSITIONS ECSP003510A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP003510 ECSP003510A (en) 2000-06-01 2000-06-01 POLYMORPHOS OF A AZOBICICLO CITRATE (2,2,2) OCT - 3 - CRYSTALLINE ILAMINE AND ITS PHARMACEUTICAL COMPOSITIONS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP003510 ECSP003510A (en) 2000-06-01 2000-06-01 POLYMORPHOS OF A AZOBICICLO CITRATE (2,2,2) OCT - 3 - CRYSTALLINE ILAMINE AND ITS PHARMACEUTICAL COMPOSITIONS

Publications (1)

Publication Number Publication Date
ECSP003510A true ECSP003510A (en) 2000-07-21

Family

ID=42041135

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP003510 ECSP003510A (en) 2000-06-01 2000-06-01 POLYMORPHOS OF A AZOBICICLO CITRATE (2,2,2) OCT - 3 - CRYSTALLINE ILAMINE AND ITS PHARMACEUTICAL COMPOSITIONS

Country Status (1)

Country Link
EC (1) ECSP003510A (en)

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