ECSP003519A - ETHANOSULPHONYL-PIPERIDINE DERIVATIVES - Google Patents
ETHANOSULPHONYL-PIPERIDINE DERIVATIVESInfo
- Publication number
- ECSP003519A ECSP003519A ECSP003519A ECSP003519A EC SP003519 A ECSP003519 A EC SP003519A EC SP003519 A ECSP003519 A EC SP003519A EC SP003519 A ECSP003519 A EC SP003519A
- Authority
- EC
- Ecuador
- Prior art keywords
- disease
- neurodegeneration
- diseases
- compounds
- chronic
- Prior art date
Links
- 230000004770 neurodegeneration Effects 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 208000002193 Pain Diseases 0.000 abstract 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 2
- 230000001684 chronic effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a compuestos de la fórmula general (gráfico), en donde, R1 significa hidrógeno o hidroxilo; R2 significa hidrógeno o metilo; y X significa -O- ó -CH2-; y a sus sales de adición ácida famacéuticamente aceptables. Se han demostrado que estos compuestos tienen una buena afinidad para el receptor del NMDA y son por lo tanto de utilidad en el tratamiento de enfermedades, en donde las indicaciones terapéuticas incluyen formas agudas de neurodegeneración causadas p.Ej., por una apoplejía o un trauma cerebral; formas crónicas de neurodegeneración tales como la enfermedad de Alzheimer, enfermedad de Parkinson, enfermedad de Huntington o ALS (esclerosis lateral amiotrófica); neurodegeneración asociada con infecciones bacterianas o víricas y enfermedades tales como la esquizofrenia, ansiedad, depresión y dolor crónico/agudo.The invention relates to compounds of the general formula (graph), wherein, R1 means hydrogen or hydroxyl; R2 means hydrogen or methyl; and X means -O- or -CH2-; and to its pharmaceutically acceptable acid addition salts. These compounds have been shown to have a good affinity for the NMDA receptor and are therefore useful in the treatment of diseases, where the therapeutic indications include acute forms of neurodegeneration caused e.g. by stroke or trauma. cerebral; chronic forms of neurodegeneration such as Alzheimer's disease, Parkinson's disease, Huntington's disease or ALS (amyotrophic lateral sclerosis); neurodegeneration associated with bacterial or viral infections and diseases such as schizophrenia, anxiety, depression and chronic / acute pain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003519 ECSP003519A (en) | 2000-06-08 | 2000-06-08 | ETHANOSULPHONYL-PIPERIDINE DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003519 ECSP003519A (en) | 2000-06-08 | 2000-06-08 | ETHANOSULPHONYL-PIPERIDINE DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003519A true ECSP003519A (en) | 2001-01-23 |
Family
ID=42041143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003519 ECSP003519A (en) | 2000-06-08 | 2000-06-08 | ETHANOSULPHONYL-PIPERIDINE DERIVATIVES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003519A (en) |
-
2000
- 2000-06-08 EC ECSP003519 patent/ECSP003519A/en unknown
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