ECSP003554A - HIGHLY SELECTIVE INHIBITORS FOR NOREPINEPHRINE RECOVERY AND METHODS FOR USING THEM - Google Patents
HIGHLY SELECTIVE INHIBITORS FOR NOREPINEPHRINE RECOVERY AND METHODS FOR USING THEMInfo
- Publication number
- ECSP003554A ECSP003554A ECSP003554A ECSP003554A EC SP003554 A ECSP003554 A EC SP003554A EC SP003554 A ECSP003554 A EC SP003554A EC SP003554 A ECSP003554 A EC SP003554A
- Authority
- EC
- Ecuador
- Prior art keywords
- methods
- norepinephrine
- disorder
- compositions
- highly selective
- Prior art date
Links
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 229960002748 norepinephrine Drugs 0.000 title abstract 3
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 title abstract 3
- 238000011084 recovery Methods 0.000 title abstract 2
- 229940124639 Selective inhibitor Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 5
- 241000282412 Homo Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 208000020016 psychiatric disease Diseases 0.000 abstract 2
- CBQGYUDMJHNJBX-RTBURBONSA-N reboxetine Chemical compound CCOC1=CC=CC=C1O[C@H](C=1C=CC=CC=1)[C@@H]1OCCNC1 CBQGYUDMJHNJBX-RTBURBONSA-N 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229960003770 reboxetine Drugs 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Metodos y composiciones para trarar a humanos que sufren de, ó prevenir que un humano sufra de una enfermedad, desórden o una condición psicológica o psiquiátrica, medinate la cual se prohibe la recuperación de la norepinefrina es un beneficio, tal como se divulga en el presente texto. Las composiciones comprenden de un compuesto que tiene una selectividad farmacológica de serotonina (Ki)/norepinefrina (Ki) de por lo menos aproximadamente 5000. Ejemplos de dichos compuestos incluyen reboxetina y más preferiblemente un enantiómero de reboxetina ópticamente puro (S,S). Los métodos generalmente incluyen la administración de una cantidad terapéutica de dichas composiciones. Adicionalmente se divulga las preparaciones de un medicamento de la composición y usos de la composición en la preparación del medicamento para tratar a humanos que sufren de, o prevenir a un humano que sufra de una enfermedad desórden o condición psicológica o psiquiátrica.Methods and compositions for treating humans suffering from, or preventing a human suffering from a psychological or psychiatric illness, disorder, or condition, by which the recovery of norepinephrine is prohibited is a benefit, as disclosed herein. text. The compositions comprise of a compound having a serotonin (Ki) / norepinephrine (Ki) pharmacological selectivity of at least about 5000. Examples of such compounds include reboxetine and more preferably an optically pure reboxetine enantiomer (S, S). The methods generally include the administration of a therapeutic amount of such compositions. Additionally disclosed are preparations of a medicament of the composition and uses of the composition in the preparation of the medicament for treating humans suffering from, or preventing a human suffering from a disorder, psychological or psychiatric condition or disorder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003554 ECSP003554A (en) | 2000-06-30 | 2000-06-30 | HIGHLY SELECTIVE INHIBITORS FOR NOREPINEPHRINE RECOVERY AND METHODS FOR USING THEM |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003554 ECSP003554A (en) | 2000-06-30 | 2000-06-30 | HIGHLY SELECTIVE INHIBITORS FOR NOREPINEPHRINE RECOVERY AND METHODS FOR USING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003554A true ECSP003554A (en) | 2000-10-24 |
Family
ID=42041169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003554 ECSP003554A (en) | 2000-06-30 | 2000-06-30 | HIGHLY SELECTIVE INHIBITORS FOR NOREPINEPHRINE RECOVERY AND METHODS FOR USING THEM |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003554A (en) |
-
2000
- 2000-06-30 EC ECSP003554 patent/ECSP003554A/en unknown
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