ECSP003614A - CHEMICAL COMPOUNDS XXII - Google Patents
CHEMICAL COMPOUNDS XXIIInfo
- Publication number
- ECSP003614A ECSP003614A ECSP003614A ECSP003614A EC SP003614 A ECSP003614 A EC SP003614A EC SP003614 A ECSP003614 A EC SP003614A EC SP003614 A ECSP003614 A EC SP003614A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- hydrogen
- partially unsaturated
- disorders
- carboaryloxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- -1 alkylsulfoxyl Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 102000006902 5-HT2C Serotonin Receptor Human genes 0.000 abstract 1
- 108010072553 5-HT2C Serotonin Receptor Proteins 0.000 abstract 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 102000014630 G protein-coupled serotonin receptor activity proteins Human genes 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- LELOWRISYMNNSU-UHFFFAOYSA-N Hydrocyanic acid Chemical group N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 201000010064 diabetes insipidus Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000002859 sleep apnea Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
(GRÁFICO), en la que R1 y R2 se seleccionan independientemente de hidrógeno y alquilo, R3 es alquilo R4, R6 y R7 se selccionan independientemente de hidrógeno, halógeno, hidroxi, alquilo, arilo, amino, alquilamino, dialquilamino, alcoxi, ariloxi, alquiltio, alquilsulfoxilo, alquilsulfonilo, nitro, carbonitrilo, carboalcoxi, carboariloxi, carboxilo, R5 se selcciona de hidrógeno, halógeno, hidroxi, alquilo, arilo, amino, alquilamino, dialquilamino, alcoxi, ariloxi, alquiltio, alquilsulfoxilo, alquilsulfonilo, nitro, carbonitrilo, carboalcoxi, carboariloxi, y carboxilo, A es un anillo heterociclico parcialmente insaturado o aromático de 5 ¿o 6 eslabones o un anillo carbocíclico parcialmente insaturado de 5 o 6 eslabones, en el que si A es un anillo carbocíclico parcialmente insaturado de 6 eslabones, entonces al menos uno de R4 a R7 es distinto de hidrógeno, y las sales; compuestos promedicamentos farmacéuticamente aceptables de estos y el uso de éstos en terapia, particularmente como agonistas o antagonistas de un receptor de 5-HT, particularmente un receptor de 5-HT2c por ejemplo en el tratamiento de trastornos del sistema nervioso central, daño al sistema nervioso central, trastornos cardiovasculares, trastornos gastrointestinales, diabetes insípida y apnea del sueño, y particularmente para el tratamiento de la obesidad.(GRAPH), where R1 and R2 are independently selected from hydrogen and alkyl, R3 is alkyl, R4, R6 and R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, alkylsulfonyl, nitro, carbonitrile, carboalkoxy, carboaryloxy, carboxyl, R5 is selected from hydrogen, halogen, hydroxy, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, alkylsulfonyl, nitro, carbonyl carboalkoxy, carboaryloxy, and carboxyl, A is a 5- or 6-membered aromatic or partially unsaturated heterocyclic ring or a 5- or 6-membered partially unsaturated carbocyclic ring, wherein if A is a 6-membered partially unsaturated carbocyclic ring, then at least one of R4 to R7 is other than hydrogen, and the salts; Pharmaceutically acceptable prodrug compounds thereof and the use of these in therapy, particularly as agonists or antagonists of a 5-HT receptor, particularly a 5-HT2c receptor eg in the treatment of disorders of the central nervous system, damage to the nervous system central, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus and sleep apnea, and particularly for the treatment of obesity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003614 ECSP003614A (en) | 2000-08-11 | 2000-08-11 | CHEMICAL COMPOUNDS XXII |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003614 ECSP003614A (en) | 2000-08-11 | 2000-08-11 | CHEMICAL COMPOUNDS XXII |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003614A true ECSP003614A (en) | 2000-10-24 |
Family
ID=42041220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003614 ECSP003614A (en) | 2000-08-11 | 2000-08-11 | CHEMICAL COMPOUNDS XXII |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003614A (en) |
-
2000
- 2000-08-11 EC ECSP003614 patent/ECSP003614A/en unknown
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