ECSP003642A - MUSCARINIC ANTAGONISTS - Google Patents

MUSCARINIC ANTAGONISTS

Info

Publication number
ECSP003642A
ECSP003642A ECSP003642A ECSP003642A EC SP003642 A ECSP003642 A EC SP003642A EC SP003642 A ECSP003642 A EC SP003642A EC SP003642 A ECSP003642 A EC SP003642A
Authority
EC
Ecuador
Prior art keywords
muscarinic antagonists
alkoxy
halogen
graph
alkyl
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Joseph A Kozlowski
John W Clader
Michael W Miller
Stuart W Mccombie
Susan F Vice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP003642 priority Critical patent/ECSP003642A/en
Publication of ECSP003642A publication Critical patent/ECSP003642A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Derivados de amida de compuestos de piperidina 1,4-disustituida de la fórmula (gráfico), o una sal, éster o solvato farmacéuticamente aceptable del mismo, en donde Q y Q1 son cada uno -CH=, o uno de Q y Q1 es -CH= y el otro es N=; X es -CH2- o (gráfico), Y y Z son -C(R5)=, o uno de Y y Z es -C(R5)=y el otro es -N=; R1 es de 1 a 3 sustituyentes seleccionados entre H, halógeno y alcoxi; R2 y R5 son de 1 a 3 sustituyentes seleccionados entre H, halógeno, alquilo y alcoxi; y R3 y R4 son H o alquilo (C1-C6) son antagonistas muscarínicos útiles para el tratamiento de trastornos cognitivos como ser la enfermedad de Alzheimer. También se describen composiciones farmacéuticas y métodos de preparación.Amide derivatives of 1,4-disubstituted piperidine compounds of the formula (graph), or a pharmaceutically acceptable salt, ester or solvate thereof, wherein Q and Q1 are each -CH =, or one of Q and Q1 is -CH = and the other is N =; X is -CH2- or (graph), Y and Z are -C (R5) =, or one of Y and Z is -C (R5) = and the other is -N =; R1 is 1 to 3 substituents selected from H, halogen and alkoxy; R2 and R5 are 1 to 3 substituents selected from H, halogen, alkyl and alkoxy; and R3 and R4 are H or (C1-C6) alkyl are muscarinic antagonists useful for the treatment of cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and preparation methods are also described.

ECSP003642 2000-08-31 2000-08-31 MUSCARINIC ANTAGONISTS ECSP003642A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP003642 ECSP003642A (en) 2000-08-31 2000-08-31 MUSCARINIC ANTAGONISTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP003642 ECSP003642A (en) 2000-08-31 2000-08-31 MUSCARINIC ANTAGONISTS

Publications (1)

Publication Number Publication Date
ECSP003642A true ECSP003642A (en) 2001-03-22

Family

ID=42041242

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP003642 ECSP003642A (en) 2000-08-31 2000-08-31 MUSCARINIC ANTAGONISTS

Country Status (1)

Country Link
EC (1) ECSP003642A (en)

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