ECSP003652A - TREATMENT OF COMBINATION WITH I1-1ra AND COMPOUNDS THAT INHIBIT THE PROCESSING AND RELEASE OF I1-1 - Google Patents

TREATMENT OF COMBINATION WITH I1-1ra AND COMPOUNDS THAT INHIBIT THE PROCESSING AND RELEASE OF I1-1

Info

Publication number
ECSP003652A
ECSP003652A EC2000003652A ECSP003652A ECSP003652A EC SP003652 A ECSP003652 A EC SP003652A EC 2000003652 A EC2000003652 A EC 2000003652A EC SP003652 A ECSP003652 A EC SP003652A EC SP003652 A ECSP003652 A EC SP003652A
Authority
EC
Ecuador
Prior art keywords
release
combination
processing
inhibit
compounds
Prior art date
Application number
EC2000003652A
Other languages
Spanish (es)
Inventor
Joseph Tardio
Paul Hadvary
Hans Lengsfeld
Hans Steffen
Bruce Henry Littman
Marcel Schmid
Farland Small Donald Mac
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP003652A publication Critical patent/ECSP003652A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

El invento se refiere a métodos y composiciones para tratar y prevenir estados de enfermedad por la interleuquina 1 (IL-1). En los métodos y las composiciones se usa un polipáptido antagonista del receptor de la interleuquina 1(I1-1ra.), o una variante del mismo, en combinación con un agente no esteroide que inhibe el procesamiento y la liberación del I1-1.The invention relates to methods and compositions for treating and preventing disease states by interleukin 1 (IL-1). In methods and compositions, an interleukin 1 receptor antagonist polypeptide (I1-1ra.), Or a variant thereof, is used in combination with a non-steroid agent that inhibits the processing and release of I1-1.

EC2000003652A 1999-09-14 2000-09-12 TREATMENT OF COMBINATION WITH I1-1ra AND COMPOUNDS THAT INHIBIT THE PROCESSING AND RELEASE OF I1-1 ECSP003652A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15401099P 1999-09-14 1999-09-14

Publications (1)

Publication Number Publication Date
ECSP003652A true ECSP003652A (en) 2002-04-23

Family

ID=22549650

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2000003652A ECSP003652A (en) 1999-09-14 2000-09-12 TREATMENT OF COMBINATION WITH I1-1ra AND COMPOUNDS THAT INHIBIT THE PROCESSING AND RELEASE OF I1-1

Country Status (13)

Country Link
EP (1) EP1214087A1 (en)
JP (1) JP2003509378A (en)
AR (1) AR033650A1 (en)
AU (1) AU6464400A (en)
BR (1) BR0014003A (en)
CA (1) CA2383026A1 (en)
CO (1) CO5190701A1 (en)
EC (1) ECSP003652A (en)
GT (1) GT200000155A (en)
PA (1) PA8502901A1 (en)
PE (1) PE20010685A1 (en)
TN (1) TNSN00183A1 (en)
WO (1) WO2001019390A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1729810T (en) 2004-04-02 2018-11-22 Swedish Orphan Biovitrum Ab Publ Methods of reducing aggregation of il-1ra
WO2008129288A2 (en) * 2007-04-19 2008-10-30 Boehringer Ingelheim International Gmbh Disulfonamides useful in the treatment of inflammation
MY193765A (en) * 2015-02-16 2022-10-27 Univ Queensland Sulfonylureas and related compounds and use of same
US11858922B2 (en) 2016-02-16 2024-01-02 The University Of Queensland Sulfonylureas and related compounds and use of same
JP7050751B2 (en) 2016-04-18 2022-04-08 ノバルティス アーゲー Compounds and compositions for treating conditions associated with NLRP activity
JP7163293B2 (en) 2017-01-23 2022-10-31 ジェネンテック， インコーポレイテッド Chemical compounds as inhibitors of interleukin-1 activity
US11840543B2 (en) 2017-05-24 2023-12-12 The University Of Queensland Compounds and uses
US11236045B2 (en) 2017-06-09 2022-02-01 Cadila Healthcare Limited Substituted sulfoximine compounds
WO2019008029A1 (en) 2017-07-07 2019-01-10 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
HRP20220195T1 (en) 2017-07-07 2022-04-15 Inflazome Limited Novel sulfonamide carboxamide compounds
CN117209447A (en) 2017-07-24 2023-12-12 诺华股份有限公司 Compounds and compositions for treating disorders associated with NLRP activity
EP3668843A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
PE20200758A1 (en) 2017-08-15 2020-07-27 Inflazome Ltd SULFONYLUREAS AND SULFONYLTIOUREAS AS INHIBITORS OF NLRP3
EP3668601A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Novel sulfonamide carboxamide compounds
EP3668840A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Novel sulfonamide carboxamide compounds
TW201910317A (en) 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 Novel compound
WO2019043610A1 (en) 2017-08-31 2019-03-07 Cadila Healthcare Limited Novel substituted sulfonylurea derivatives
WO2019068772A1 (en) 2017-10-03 2019-04-11 Inflazome Limited Novel compounds
CA3078195A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
WO2019092171A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
WO2019166632A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
US11884645B2 (en) 2018-03-02 2024-01-30 Inflazome Limited Sulfonyl acetamides as NLRP3 inhibitors
WO2019166627A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
US11905252B2 (en) 2018-03-02 2024-02-20 Inflazome Limited Compounds
WO2019166633A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Sulfonamide derivates as nlrp3 inhibitors
EP3759090A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
GB201806578D0 (en) * 2018-04-23 2018-06-06 Inflazome Ltd Novel compound
JP2021529187A (en) 2018-07-03 2021-10-28 ノバルティス アーゲー NLRP modulator
PE20211811A1 (en) 2018-07-20 2021-09-14 Hoffmann La Roche SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY
CA3104199A1 (en) 2018-07-20 2020-01-23 F. Hoffmann-La Roche Ag Sulfonylurea compounds as inhibitors of interleukin-1 activity
PE20211333A1 (en) 2018-08-15 2021-07-22 Inflazome Ltd NOVEL SULFONAMIDAUREA COMPOUNDS
JP2022505525A (en) * 2018-10-24 2022-01-14 ノバルティス アーゲー Compounds and compositions for treating conditions associated with NLRP activity
CN113474333B (en) 2019-01-14 2025-06-13 载度思生命科学有限公司 New substituted sulfonylurea derivatives
WO2021237891A1 (en) * 2020-05-25 2021-12-02 Beijing Vdjbio Co., Ltd. An interleukin-1 receptor antagonist and a fusion protein containing the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
BR9714328A (en) * 1997-01-29 2000-03-21 Pfizer of interleukin-1 activity
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
EP0987552A3 (en) * 1998-08-31 2000-06-07 Pfizer Products Inc. Diarylsulfonylurea binding proteins

Also Published As

Publication number Publication date
CO5190701A1 (en) 2002-08-29
AU6464400A (en) 2001-04-17
AR033650A1 (en) 2004-01-07
CA2383026A1 (en) 2001-03-22
GT200000155A (en) 2002-03-08
PA8502901A1 (en) 2002-02-21
WO2001019390A1 (en) 2001-03-22
EP1214087A1 (en) 2002-06-19
JP2003509378A (en) 2003-03-11
TNSN00183A1 (en) 2005-11-10
BR0014003A (en) 2002-05-21
PE20010685A1 (en) 2001-07-03

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