ECSP003679A - PIRIDINES AND SUBSTITUTED PYRIDACINES WITH ANGIOGENESIS INHIBITION ACTIVITY - Google Patents
PIRIDINES AND SUBSTITUTED PYRIDACINES WITH ANGIOGENESIS INHIBITION ACTIVITYInfo
- Publication number
- ECSP003679A ECSP003679A ECSP003679A ECSP003679A EC SP003679 A ECSP003679 A EC SP003679A EC SP003679 A ECSP003679 A EC SP003679A EC SP003679 A ECSP003679 A EC SP003679A
- Authority
- EC
- Ecuador
- Prior art keywords
- inhibition activity
- substituted
- ring
- pyridacines
- piridines
- Prior art date
Links
- 230000033115 angiogenesis Effects 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000004892 pyridazines Chemical class 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Piridinas y piridacinas sustituidas que tienen actividad de inhibición de angiogénesis y la fórmula estructural generalizada: donde el anillo que contiene A, B, D, E, y L es fenilo o un heterociclo que contiene nitrógeno; los grupos X e Y pueden ser cualquiera de una variedad de unidades de enlace; R1 y R2 pueden ser sustituyentes independientes definidos o juntos pueden ser un puente que define un anillo; el anillo J puede ser un grupo arilo, piridilo o cicloalquilo; y los grupos G pueden ser cualquiera de una variedad de sustituyentes definidos. También se describen composiciones farmacéuticas que contienen estos materiales y los métodos de tratamiento de un mamífero que tiene un trastorno caracterizado por procesos de angiogénesis e hipermeabilidad anormales mediante el uso de estos materiales.Pyridines and substituted pyridazines that have angiogenesis inhibition activity and the generalized structural formula: where the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; Groups X and Y can be any of a variety of link units; R1 and R2 can be defined independent substituents or together they can be a bridge defining a ring; the J ring may be an aryl, pyridyl or cycloalkyl group; and the G groups can be any of a variety of defined substituents. Pharmaceutical compositions containing these materials and the methods of treatment of a mammal having a disorder characterized by abnormal angiogenesis and hypermeability processes through the use of these materials are also described.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003679 ECSP003679A (en) | 2000-09-25 | 2000-09-25 | PIRIDINES AND SUBSTITUTED PYRIDACINES WITH ANGIOGENESIS INHIBITION ACTIVITY |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003679 ECSP003679A (en) | 2000-09-25 | 2000-09-25 | PIRIDINES AND SUBSTITUTED PYRIDACINES WITH ANGIOGENESIS INHIBITION ACTIVITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003679A true ECSP003679A (en) | 2001-06-22 |
Family
ID=42041273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003679 ECSP003679A (en) | 2000-09-25 | 2000-09-25 | PIRIDINES AND SUBSTITUTED PYRIDACINES WITH ANGIOGENESIS INHIBITION ACTIVITY |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003679A (en) |
-
2000
- 2000-09-25 EC ECSP003679 patent/ECSP003679A/en unknown
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