ECSP003711A - SGLT2 INHIBITORS OF C-ARYL GLYCOCIDES AND METHOD - Google Patents
SGLT2 INHIBITORS OF C-ARYL GLYCOCIDES AND METHODInfo
- Publication number
- ECSP003711A ECSP003711A ECSP003711A ECSP003711A EC SP003711 A ECSP003711 A EC SP003711A EC SP003711 A ECSP003711 A EC SP003711A EC SP003711 A ECSP003711 A EC SP003711A
- Authority
- EC
- Ecuador
- Prior art keywords
- aryl
- heterocycle
- independently hydrogen
- alkyl
- sglt2
- Prior art date
Links
- 229940123518 Sodium/glucose cotransporter 2 inhibitor Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- -1 -OCHF2 Chemical group 0.000 abstract 2
- 108091006269 SLC5A2 Proteins 0.000 abstract 2
- 102000058081 Sodium-Glucose Transporter 2 Human genes 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 229940125708 antidiabetic agent Drugs 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se proporciona compuestos que inhiben el SGLT2, que tiene la fórmula (gráfico), en donde R1, R2 y R2a son independientemente hidrógeno, OH, OR5, alquilo, CF3, OCHF2, OCF3, SR5i o halógeno, o dos de R1, R2 y R2a junto con los carbonos a los cuales están unidos, pueden formar un carbocíclo o heterociclo de cinco, seis o siete elementos, deseados; R3 y R4 son independientemente hidrógeno, OH, OR5a, Oarilo, OCH2 arilo, alquilo inferior, cicloalquilo, CF3, -OCHF2, -OCF3, halógeno, -CN, CO2R5b, -CO2H, -COR6b, -CH(OH)R6c, -CH(OR5b)R6d, CONR6R6a, -NHCOR5c, -NHSO2R5d, -NHSO2arilo, arilo, SR5c, -SOR5f, -SO2R5g, -SO2 arilo o un heterociclo de cinco, seis o siete elementos ó R3 y R4 junto con los carbonos a los cuales están unidos forman un carbocíclo o heterociclo de cinco, seis o siete elementos deseados; R5, R5a, R5b, R5c, R5d, R5e, R5f, R5g, R5h, R5i son independientemente alquilo inferior; R6, R6a, R6b, R6c y R6d, son independientemente hidrógeno, alquilo, arilo, alquilarilo, o cicloalquilo o R6 y R6a junto con el nitrógeno al cual están unidos, forman un heterociclo de cinco, seis o siete elementos deseados; A es O, S, NH o (CH2)n en donde n es 0-3 también proporciona el tratamiento de la diabetes y padecimientos relacionados empleando una cantidad que inhibe el SGLT2 del compuesto anterior solo o en combinación con otro agente antidiabético u otro agente terapéutico.Compounds that inhibit SGLT2 are provided, which has the formula (graph), wherein R1, R2, and R2a are independently hydrogen, OH, OR5, alkyl, CF3, OCHF2, OCF3, SR5i, or halogen, or two of R1, R2, and R2a together with the carbons to which they are attached, can form a desired five, six or seven element carbocycle or heterocycle; R3 and R4 are independently hydrogen, OH, OR5a, Oaryl, OCH2 aryl, lower alkyl, cycloalkyl, CF3, -OCHF2, -OCF3, halogen, -CN, CO2R5b, -CO2H, -COR6b, -CH (OH) R6c, - CH (OR5b) R6d, CONR6R6a, -NHCOR5c, -NHSO2R5d, -NHSO2aryl, aryl, SR5c, -SOR5f, -SO2R5g, -SO2 aryl or a heterocycle of five, six or seven elements or R3 and R4 together with the carbons to the which are joined together form a carbocycle or heterocycle of five, six or seven desired elements; R5, R5a, R5b, R5c, R5d, R5e, R5f, R5g, R5h, R5i are independently lower alkyl; R6, R6a, R6b, R6c and R6d, are independently hydrogen, alkyl, aryl, alkylaryl, or cycloalkyl, or R6 and R6a together with the nitrogen to which they are attached, form a heterocycle of five, six or seven desired elements; A is O, S, NH or (CH2) n where n is 0-3 also provides treatment for diabetes and related conditions using an amount that inhibits the SGLT2 of the above compound alone or in combination with another antidiabetic agent or other agent therapeutic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003711 ECSP003711A (en) | 2000-10-12 | 2000-10-12 | SGLT2 INHIBITORS OF C-ARYL GLYCOCIDES AND METHOD |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003711 ECSP003711A (en) | 2000-10-12 | 2000-10-12 | SGLT2 INHIBITORS OF C-ARYL GLYCOCIDES AND METHOD |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003711A true ECSP003711A (en) | 2000-11-24 |
Family
ID=42041294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003711 ECSP003711A (en) | 2000-10-12 | 2000-10-12 | SGLT2 INHIBITORS OF C-ARYL GLYCOCIDES AND METHOD |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003711A (en) |
-
2000
- 2000-10-12 EC ECSP003711 patent/ECSP003711A/en unknown
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