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Polysaccharides And Polysaccharide Derivatives
(AREA)
Abstract
Se describe un derivado de 6-mercapto-ciclodextrina que tiene la fórmula general I: donde m es 0-7, n es 1-8, m+n + 7 u 8; R es (C1-6)-alquileno, opcionalmente sustituido con 1-3 grupos OH, ó (CH2) o-fenileno-(CH2)p -; o, p son independientemente 0-4; X es COOH, CONHR1, NHCOR2, SO2OH, PO(OH) 2, O(CH2 -CH2-O) q-H, OH o tetrazol-5- ilo; R1 es H ó (C1-3) alquilo; R2 es carboxifenilo; q es 1-3; o sales farmacéuticamente aceptables del mismo. El derivado de 6-mercapto-ciclodextrina usados como agentes de reversión para el bloqueo neuromuscular inducido para fármacos.A 6-mercapto-cyclodextrin derivative having the general formula I is described: where m is 0-7, n is 1-8, m + n + 7 or 8; R is (C1-6) -alkylene, optionally substituted with 1-3 OH groups, or (CH2) o-phenylene- (CH2) p -; or, p are independently 0-4; X is COOH, CONHR1, NHCOR2, SO2OH, PO (OH) 2, O (CH2 -CH2-O) q-H, OH or tetrazol-5- yl; R1 is H or (C1-3) alkyl; R2 is carboxyphenyl; q is 1-3; or pharmaceutically acceptable salts thereof. The 6-mercapto-cyclodextrin derivative used as reversal agents for drug-induced neuromuscular blockade.
ECSP0037852000-11-242000-11-24
DERIVATIVES OF 6-MERCAPTO-CYCLODEXTRINE: REVERSION AGENTS FOR NEUROMUSCULAR BLOCK Induced by Pharmaceuticals
ECSP003785A
(en)
A DERIVATIVE OF 6-MERCAPTO-CYCLODEXTRINE, ITS USE, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, A KIT TO PROVIDE NEUROMUSCULAR BLOCK AND SUREVERSION, AND A METHOD FOR THE REVERSION OF THE NEUROMUSCULAR LOCK LOCKED BY PHARMACOS