ECSP003845A - NITRILE DERIVATIVES AS CATEPSIN K INHIBITORS - Google Patents
NITRILE DERIVATIVES AS CATEPSIN K INHIBITORSInfo
- Publication number
- ECSP003845A ECSP003845A ECSP003845A ECSP003845A EC SP003845 A ECSP003845 A EC SP003845A EC SP003845 A ECSP003845 A EC SP003845A EC SP003845 A ECSP003845 A EC SP003845A
- Authority
- EC
- Ecuador
- Prior art keywords
- diseases
- compounds
- pharmaceutically acceptable
- angina pectoris
- catepsin
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000002825 nitriles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 201000004569 Blindness Diseases 0.000 abstract 1
- 102000005927 Cysteine Proteases Human genes 0.000 abstract 1
- 108010005843 Cysteine Proteases Proteins 0.000 abstract 1
- 208000005189 Embolism Diseases 0.000 abstract 1
- 206010018364 Glomerulonephritis Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000032109 Transient ischaemic attack Diseases 0.000 abstract 1
- 208000007814 Unstable Angina Diseases 0.000 abstract 1
- 206010001902 amaurosis Diseases 0.000 abstract 1
- 238000002399 angioplasty Methods 0.000 abstract 1
- 210000001367 artery Anatomy 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000010875 transient cerebral ischemia Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a compuestos de fórmula (I) En donde R1 a R7 e Y son tal como se definen en la descripción y las reivindicaciones, y las sales farmacéuticamente aceptables y/o ésteres farmacéuticamente aceptables de los mismos. Los compuestos son útiles para el tratamiento de enfermedades que estén asociadas con las proteasas cisteínicas, tales como la osteoporósis, osteoartritis, artritis reumatoide, metástasis tumoral, glomerulonefritis, arterosclerosis, infarto de miocardio, angina de pecho, angina de pecho inestable, embolia, rotura de placa, ataques isquémicos transitorios, amaurosis fugax, enfermedad oclusiva de las arterias periféricas, restenosis después de angioplastia y colocación de stents, formación de aneurismo aórtico, inflamación, enfermedades autoinmunes, malaria, citopatía del tejido del fondo ocular, y enfermedades respiratorias.The present invention relates to compounds of formula (I) wherein R1 to R7 and Y are as defined in the description and claims, and pharmaceutically acceptable salts and / or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment of diseases that are associated with cysteine proteases, such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, unstable angina pectoris, embolism, rupture of plaque, transient ischemic attacks, fugax amaurosis, peripheral artery occlusive disease, restenosis after angioplasty and stenting, formation of aortic aneurism, inflammation, autoimmune diseases, malaria, ocular fundus cytopathy, and respiratory diseases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003845 ECSP003845A (en) | 2000-12-21 | 2000-12-21 | NITRILE DERIVATIVES AS CATEPSIN K INHIBITORS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003845 ECSP003845A (en) | 2000-12-21 | 2000-12-21 | NITRILE DERIVATIVES AS CATEPSIN K INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003845A true ECSP003845A (en) | 2001-07-27 |
Family
ID=42041395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003845 ECSP003845A (en) | 2000-12-21 | 2000-12-21 | NITRILE DERIVATIVES AS CATEPSIN K INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003845A (en) |
-
2000
- 2000-12-21 EC ECSP003845 patent/ECSP003845A/en unknown
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