ECSP014068A - Procedimiento para regular la angiogenesis utilizando proteina ryk - Google Patents

Procedimiento para regular la angiogenesis utilizando proteina ryk

Info

Publication number
ECSP014068A
ECSP014068A EC2001004068A ECSP014068A ECSP014068A EC SP014068 A ECSP014068 A EC SP014068A EC 2001004068 A EC2001004068 A EC 2001004068A EC SP014068 A ECSP014068 A EC SP014068A EC SP014068 A ECSP014068 A EC SP014068A
Authority
EC
Ecuador
Prior art keywords
ryk
angiogenesis
diseases
procedure
proteins
Prior art date
Application number
EC2001004068A
Other languages
English (en)
Inventor
Alya Zolotorev
Nathalie A Dubois-Stringfellow
Steve Roczniak
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of ECSP014068A publication Critical patent/ECSP014068A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se encontró que la proteína Ryk tenia una novedosa actividad en la regulación de la angiogenesis, se construyeron nuevas proteínas Ryk variantes que son ventajosas para modular la actividad formadora de capilares de las células endoteliales, las proteínas Ryk variantes pueden ser utilizadas como agentes terapéuticos en enfermedades tales como el cáncer, la cicratización de heridas, las retinopatías diabéticas, la degeneración macular y las enfermedades cardiovasculares, así como otras enfermedades o trastornos clínicos en la que la angiogenesis esta involucrada en la causa o el tratamiento de la enfermedad.
EC2001004068A 2000-05-10 2001-05-09 Procedimiento para regular la angiogenesis utilizando proteina ryk ECSP014068A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56878300A 2000-05-10 2000-05-10

Publications (1)

Publication Number Publication Date
ECSP014068A true ECSP014068A (es) 2002-02-25

Family

ID=24272718

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2001004068A ECSP014068A (es) 2000-05-10 2001-05-09 Procedimiento para regular la angiogenesis utilizando proteina ryk

Country Status (13)

Country Link
EP (1) EP1287121A2 (es)
JP (1) JP2004527206A (es)
AR (1) AR028424A1 (es)
AU (1) AU2001261343A1 (es)
CA (1) CA2408349A1 (es)
CO (1) CO5300464A1 (es)
DO (1) DOP2001000164A (es)
EC (1) ECSP014068A (es)
GT (1) GT200100079A (es)
PE (1) PE20011218A1 (es)
SV (1) SV2002000442A (es)
UY (1) UY26696A1 (es)
WO (1) WO2001085789A2 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10501523B2 (en) 2014-07-18 2019-12-10 Sanofi IL-8 level based method of predicting the outcome of colon cancer treatment
US11033606B2 (en) 2011-04-26 2021-06-15 Sanofi Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-FU) and irinotecan (FOLFIRI)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050180959A1 (en) * 2002-02-06 2005-08-18 Karsten Eulenberg Kinases involved in the regulation of energy homeostasis
JP2024535691A (ja) * 2021-08-18 2024-10-02 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア 抗受容体チロシンキナーゼ関連タンパク質（Ｒｙｋ）抗体及びその使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07506969A (ja) * 1992-05-11 1995-08-03 ルードヴィッヒ・インスティテュート・フォア・キャンサー・リサーチ レセプタ型チロシンキナーゼ類似の分子
WO1996020403A1 (en) * 1994-12-23 1996-07-04 Ludwig Institute For Cancer Research Assay, receptor proteins and ligands
EP1084245B1 (en) * 1998-06-11 2006-03-29 AstraZeneca AB Human receptor tyrosine kinase
WO2000024415A2 (en) * 1998-10-28 2000-05-04 Cornell Research Foundation, Inc. Methods for regulating angiogenesis and vascular integrity using trk receptor ligands

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11033606B2 (en) 2011-04-26 2021-06-15 Sanofi Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-FU) and irinotecan (FOLFIRI)
US10501523B2 (en) 2014-07-18 2019-12-10 Sanofi IL-8 level based method of predicting the outcome of colon cancer treatment
US11208461B2 (en) 2014-07-18 2021-12-28 Sanofi Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer

Also Published As

Publication number Publication date
CO5300464A1 (es) 2003-07-31
UY26696A1 (es) 2001-12-28
EP1287121A2 (en) 2003-03-05
SV2002000442A (es) 2002-07-03
DOP2001000164A (es) 2002-05-15
JP2004527206A (ja) 2004-09-09
PE20011218A1 (es) 2002-02-01
GT200100079A (es) 2001-12-31
CA2408349A1 (en) 2001-11-15
AR028424A1 (es) 2003-05-07
AU2001261343A1 (en) 2001-11-20
WO2001085789A2 (en) 2001-11-15
WO2001085789A3 (en) 2002-05-16

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