ECSP014130A - Compuestos heterociclicos como ligandos de los receptores gaba. - Google Patents

Compuestos heterociclicos como ligandos de los receptores gaba.

Info

Publication number
ECSP014130A
ECSP014130A EC2001004130A ECSP014130A ECSP014130A EC SP014130 A ECSP014130 A EC SP014130A EC 2001004130 A EC2001004130 A EC 2001004130A EC SP014130 A ECSP014130 A EC SP014130A EC SP014130 A ECSP014130 A EC SP014130A
Authority
EC
Ecuador
Prior art keywords
agonists
ligandos
gaba
receivers
compounds
Prior art date
Application number
EC2001004130A
Other languages
English (en)
Inventor
George Maynard
Daniel Yohannes
Jun Yuan
Linghong Xie
Kungae Lee
Manuka Ghosh
George Luke
Xiaojun Liu
Albert Vincent Lawrence
Kevin Currie
Zhe-Qing Wang
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of ECSP014130A publication Critical patent/ECSP014130A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Catalysts (AREA)

Abstract

Lo que se divulga en el presente son compuestos heterocíclicos de la fórmula. Y sales farmacéuticas aceptables de la misma cuya característica es que las variables A, V, Y, J, E, X, T, G, Q, W, Z, b, n y m se definen en el presente. Estos compuestos son agonistas, antagonistas o agonistas invertidos?? Altamente selectivos para los receptores cerebrales GABAA O pro-fármacos de agonistas, antagonistas o agonistas invertidos para los receptores cerebrales GABAA.
EC2001004130A 2000-08-07 2001-08-07 Compuestos heterociclicos como ligandos de los receptores gaba. ECSP014130A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22366900P 2000-08-07 2000-08-07

Publications (1)

Publication Number Publication Date
ECSP014130A true ECSP014130A (es) 2002-03-25

Family

ID=22837525

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2001004130A ECSP014130A (es) 2000-08-07 2001-08-07 Compuestos heterociclicos como ligandos de los receptores gaba.

Country Status (19)

Country Link
US (2) US6653471B2 (es)
EP (1) EP1325006A2 (es)
JP (1) JP2004505942A (es)
KR (1) KR20030036678A (es)
CN (1) CN1468241A (es)
AU (1) AU2001285401A1 (es)
BR (1) BR0113120A (es)
CA (1) CA2420967A1 (es)
CO (1) CO5310576A1 (es)
EC (1) ECSP014130A (es)
HN (1) HN2002000193A (es)
IL (1) IL154310A0 (es)
MX (1) MXPA03001186A (es)
PA (1) PA8524601A1 (es)
PE (1) PE20020275A1 (es)
PY (1) PY0119496A (es)
TN (1) TNSN01122A1 (es)
UY (1) UY26874A1 (es)
WO (1) WO2002012442A2 (es)

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US20070099911A1 (en) * 2005-10-28 2007-05-03 Wyeth Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands
WO2007053352A2 (en) * 2005-10-28 2007-05-10 Wyeth Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands
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US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
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TWI649318B (zh) 2013-04-19 2019-02-01 英塞特控股公司 作為ｆｇｆｒ抑制劑之雙環雜環
KR101612179B1 (ko) * 2013-04-19 2016-04-12 영남대학교 산학협력단 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염을 유효성분으로 함유하는 암질환 예방 또는 치료용 약학조성물
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Also Published As

Publication number Publication date
AU2001285401A1 (en) 2002-02-18
IL154310A0 (en) 2003-09-17
CA2420967A1 (en) 2002-02-14
WO2002012442A3 (en) 2003-05-01
KR20030036678A (ko) 2003-05-09
HN2002000193A (es) 2002-11-05
TNSN01122A1 (fr) 2005-11-10
UY26874A1 (es) 2002-03-22
JP2004505942A (ja) 2004-02-26
US6949562B2 (en) 2005-09-27
US20040110778A1 (en) 2004-06-10
PA8524601A1 (es) 2003-09-05
CN1468241A (zh) 2004-01-14
US6653471B2 (en) 2003-11-25
BR0113120A (pt) 2004-06-22
CO5310576A1 (es) 2003-08-29
EP1325006A2 (en) 2003-07-09
US20030105081A1 (en) 2003-06-05
WO2002012442A2 (en) 2002-02-14
PE20020275A1 (es) 2002-04-09
MXPA03001186A (es) 2004-04-20
PY0119496A (es) 2003-11-03

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