ECSP024267A - IMIDAZOTRIAZINONES REPLACED BY 2-PHENYL - Google Patents
IMIDAZOTRIAZINONES REPLACED BY 2-PHENYLInfo
- Publication number
- ECSP024267A ECSP024267A EC2002004267A ECSP024267A ECSP024267A EC SP024267 A ECSP024267 A EC SP024267A EC 2002004267 A EC2002004267 A EC 2002004267A EC SP024267 A ECSP024267 A EC SP024267A EC SP024267 A ECSP024267 A EC SP024267A
- Authority
- EC
- Ecuador
- Prior art keywords
- phenyl
- imidazotriazinones
- replaced
- treatment
- diseases
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 2-Phenyl-substituted imidazotriazinones Chemical class 0.000 abstract 1
- YQQHMYAEQTYRKO-UHFFFAOYSA-N 2-phenyl-3h-imidazo[4,5-d]triazin-4-one Chemical class N1=C2N=CN=C2C(=O)NN1C1=CC=CC=C1 YQQHMYAEQTYRKO-UHFFFAOYSA-N 0.000 abstract 1
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 210000002229 urogenital system Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Las imidazotriazinonas 2-fenil-sustituidas que tienen radicales de alquilo lineales cortas, en la posición 9 se preparan de las correspondientes imidazotriazinonas 2-fenil por clorosulfonación y la reacción subsecuente con las aminas. Los compuestos que inhiben las fosfodiesterasas que metabolizan el GMPc y son apropiadas para utilizarse como compuestos activos en los medicamentos, para el tratamiento de enfermedades cardiovasculares y cerebrovasculares y/o enfermedades del sistema urogenital, en particular el tratamiento de la disfunción eréctil2-Phenyl-substituted imidazotriazinones having short linear alkyl radicals, at position 9, are prepared from the corresponding 2-phenyl imidazotriazinones by chlorosulfonation and subsequent reaction with the amines. Compounds that inhibit phosphodiesterases that metabolize cGMP and are suitable for use as active compounds in drugs, for the treatment of cardiovascular and cerebrovascular diseases and / or diseases of the urogenital system, in particular the treatment of erectile dysfunction
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19750085A DE19750085A1 (en) | 1997-11-12 | 1997-11-12 | New 2-phenyl-imidazotriazinone derivatives used for treating cardiovascular, cerebrovascular and urogenital disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP024267A true ECSP024267A (en) | 2002-06-26 |
Family
ID=7848473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2002004267A ECSP024267A (en) | 1997-11-12 | 2002-05-28 | IMIDAZOTRIAZINONES REPLACED BY 2-PHENYL |
Country Status (6)
| Country | Link |
|---|---|
| DE (1) | DE19750085A1 (en) |
| EC (1) | ECSP024267A (en) |
| GT (1) | GT199800183A (en) |
| RU (1) | RU2260593C2 (en) |
| SV (1) | SV1998000135A (en) |
| ZA (1) | ZA9810297B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0113343D0 (en) * | 2001-06-01 | 2001-07-25 | Bayer Ag | Novel Heterocycles 2 |
| EP2619208B1 (en) * | 2010-09-20 | 2016-11-09 | Ironwood Pharmaceuticals, Inc. | Imidazotriazinone compounds |
| CN102134242B (en) * | 2011-01-21 | 2013-08-28 | 浙江大德药业集团有限公司 | Novel compounds for quickly treating impotence with long-lasting action |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
-
1997
- 1997-11-12 DE DE19750085A patent/DE19750085A1/en not_active Withdrawn
-
1998
- 1998-10-31 RU RU2000115281/04A patent/RU2260593C2/en active
- 1998-11-11 ZA ZA9810297A patent/ZA9810297B/en unknown
- 1998-11-11 GT GT199800183A patent/GT199800183A/en unknown
- 1998-11-12 SV SV1998000135A patent/SV1998000135A/en active IP Right Grant
-
2002
- 2002-05-28 EC EC2002004267A patent/ECSP024267A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA9810297B (en) | 1999-05-20 |
| GT199800183A (en) | 2000-05-04 |
| DE19750085A1 (en) | 1999-05-20 |
| RU2260593C2 (en) | 2005-09-20 |
| SV1998000135A (en) | 1999-03-09 |
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