ECSP034460A - NEW HETEROCICLIC COMPOUNDS, ITS PREPARATION AND ITS USE AS MEDICATIONS, IN SPECIAL AS ANTIBACTERIALS - Google Patents

NEW HETEROCICLIC COMPOUNDS, ITS PREPARATION AND ITS USE AS MEDICATIONS, IN SPECIAL AS ANTIBACTERIALS

Info

Publication number
ECSP034460A
ECSP034460A EC2003004460A ECSP034460A ECSP034460A EC SP034460 A ECSP034460 A EC SP034460A EC 2003004460 A EC2003004460 A EC 2003004460A EC SP034460 A ECSP034460 A EC SP034460A EC SP034460 A ECSP034460 A EC SP034460A
Authority
EC
Ecuador
Prior art keywords
antibacterials
special
medications
preparation
compounds
Prior art date
Application number
EC2003004460A
Other languages
Spanish (es)
Inventor
Jozsef Aszodi
Claude Fromentin
Maxime Lampilas
David Alan Rowlands
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8853181&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP034460(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of ECSP034460A publication Critical patent/ECSP034460A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención se refiere a nuevos compuestos heterocíclicos de fórmula general (I), y sus sales con una base o un ácido: La invención se refiere, igualmente, a un procedimiento de preparación de estos compuestos, así como a su utiización como medicamentos, en especial como antibacterianos.The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for preparing these compounds, as well as their use as medicaments, in Special as antibacterials.

EC2003004460A 2000-08-01 2003-01-30 NEW HETEROCICLIC COMPOUNDS, ITS PREPARATION AND ITS USE AS MEDICATIONS, IN SPECIAL AS ANTIBACTERIALS ECSP034460A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0010121A FR2812635B1 (en) 2000-08-01 2000-08-01 NOVEL HETEROCYCLIC COMPOUNDS, PREPARATION AND USE AS MEDICAMENTS IN PARTICULAR AS ANTI-BACTERIALS

Publications (1)

Publication Number Publication Date
ECSP034460A true ECSP034460A (en) 2003-03-10

Family

ID=8853181

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004460A ECSP034460A (en) 2000-08-01 2003-01-30 NEW HETEROCICLIC COMPOUNDS, ITS PREPARATION AND ITS USE AS MEDICATIONS, IN SPECIAL AS ANTIBACTERIALS

Country Status (41)

Country Link
US (5) US7112592B2 (en)
EP (1) EP1307457B1 (en)
JP (2) JP4515704B2 (en)
KR (1) KR100632906B1 (en)
CN (1) CN1289500C (en)
AP (1) AP1614A (en)
AR (1) AR031716A1 (en)
AT (1) ATE263768T1 (en)
AU (2) AU7990501A (en)
BG (1) BG66094B1 (en)
BR (1) BRPI0112986B8 (en)
CA (1) CA2417475C (en)
CR (1) CR6895A (en)
CZ (1) CZ294956B6 (en)
DE (1) DE60102702T2 (en)
DK (1) DK1307457T3 (en)
DZ (1) DZ3397A1 (en)
EA (1) EA004920B1 (en)
EC (1) ECSP034460A (en)
EE (1) EE05183B1 (en)
ES (1) ES2220793T3 (en)
FR (1) FR2812635B1 (en)
HR (1) HRP20030034B1 (en)
HU (1) HU226889B1 (en)
IL (2) IL154187A0 (en)
MA (1) MA26938A1 (en)
ME (2) ME00060B (en)
MX (1) MXPA03000881A (en)
NO (1) NO324940B1 (en)
NZ (1) NZ523707A (en)
OA (1) OA12347A (en)
PL (2) PL216028B1 (en)
PT (1) PT1307457E (en)
RS (1) RS50214B (en)
SI (1) SI1307457T1 (en)
SK (1) SK287597B6 (en)
TR (1) TR200400859T4 (en)
TW (1) TWI292401B (en)
UA (1) UA73791C2 (en)
WO (1) WO2002010172A1 (en)
ZA (1) ZA200300676B (en)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2812635B1 (en) * 2000-08-01 2002-10-11 Aventis Pharma Sa NOVEL HETEROCYCLIC COMPOUNDS, PREPARATION AND USE AS MEDICAMENTS IN PARTICULAR AS ANTI-BACTERIALS
FR2835186B1 (en) 2002-01-28 2006-10-20 Aventis Pharma Sa NOVEL HETEROCYCLIC COMPOUNDS ACTIVE AS BETA-LACTAMASES INHIBITORS
FR2844273B1 (en) * 2002-09-05 2008-04-04 Aventis Pharma Sa NOVEL HETEROCYCLIC COMPOUNDS, METHOD AND INTERMEDIARY PREPARATION AND USE AS MEDICAMENT, IN PARTICULAR AS INHIBITORS OF BETA-LACTAMASES AND ANTI-BACTERIALS.
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
FR2848210B1 (en) * 2002-12-06 2007-10-19 Aventis Pharma Sa NOVEL HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTI-BACTERIALS AND INHIBITORS OF BETA-LACTAMASES
CA2783572C (en) 2005-12-07 2016-08-09 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
NZ574605A (en) 2006-07-13 2011-11-25 Achillion Pharmaceuticals Inc 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
EP2040698A4 (en) * 2006-07-14 2011-08-10 Shionogi & Co Oxime compounds and the use thereof
AU2007300531A1 (en) * 2006-09-27 2008-04-03 Merck Sharp & Dohme Corp. Novel inhibitors of beta-lactamase
WO2008051763A1 (en) * 2006-10-23 2008-05-02 Irm Llc Cathepsin proteases inhibitors
EP2119702A4 (en) 2007-01-31 2010-12-08 Dainippon Sumitomo Pharma Co AMIDE DERIVATIVE
FR2914923B1 (en) * 2007-04-12 2013-06-14 Novexel NOVEL HETEROCYCLIC NITROGEN COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIAL MEDICINES.
US8563732B2 (en) * 2007-05-31 2013-10-22 Shionogi & Co., Ltd. Oxyimino compounds and the use thereof
FR2921060B1 (en) * 2007-09-14 2012-06-15 Novexel NOVEL PROCESS FOR PREPARING DISUBSIDED PIPERIDINE AND NOVEL INTERMEDIATES
ES2533826T3 (en) * 2008-01-18 2015-04-15 Merck Sharp & Dohme Corp. Beta-lactamase inhibitors
EP2346820B1 (en) * 2008-06-11 2013-02-13 Shionogi & Co., Ltd. Oxycarbamoyl compounds and the use thereof
EP2921559A1 (en) 2008-06-19 2015-09-23 Astra Zeneca Holding France Use of (1r,2s,5r) 1,6-diazabicyclo [3.2.1]octane-2-carboxamide, 7-oxo-6-(sulfooxy)-, monosodium salt as a diagnostic reagent for detecting serine beta-lactamases
FR2936798B1 (en) * 2008-10-03 2012-09-28 Novexel NOVEL HETEROCYCLIC NITROGEN COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIAL MEDICINES.
FR2937034B1 (en) 2008-10-10 2012-11-23 Novexel NOVEL HETEROCYCLIC NITROGEN COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIAL MEDICINES
US20120053350A1 (en) * 2009-04-30 2012-03-01 Ian Mangion Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids
KR20120109292A (en) 2009-06-24 2012-10-08 다이닛본 스미토모 세이야꾸 가부시끼가이샤 N-substituted-cyclic amino derivative
FR2951171A1 (en) * 2009-10-09 2011-04-15 Novexel NOVEL SODIUM SALT OF A CRYSTALLIZED ENANTIOMER AZABICYCLIC COMPOUND AND NOVEL POLYMORPHIC AND PSEUDOPOLYMORPHIC FORMS AND THEIR PREPARATION
US8772490B2 (en) * 2010-12-22 2014-07-08 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivatives and process for preparing the same
SI2657234T1 (en) * 2010-12-22 2017-06-30 Meiji Seika Pharma Co., Ltd. Optically-active diazabicyclooctane derivative and method for manufacturing same
KR102143660B1 (en) * 2011-06-17 2020-08-11 화이자 안티-인펙티브스 에이비 Process for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
RU2578370C2 (en) * 2011-08-27 2016-03-27 Вокхардт Лимитед 1,6-diazabicyclo[3,2,1]octan-7-one derivatives and using them for treating bacterial infections
MX340533B (en) * 2011-08-30 2016-07-13 Wockhardt Ltd 1,6- diazabicyclo [3,2,1] octan- 7 - one derivatives and their use in the treatment of bacterial infections.
US8969567B2 (en) 2011-09-13 2015-03-03 Wockhardt Ltd. Nitrogen containing compounds and their use
EP3052497B1 (en) 2011-09-13 2017-06-28 Wockhardt Limited Nitrogen containing compounds and their use
US9505761B2 (en) 2011-12-02 2016-11-29 Fedora Pharmaceuticals Inc. Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors
US8796257B2 (en) 2011-12-02 2014-08-05 Naeja Pharmaceutical Inc. Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
US8969570B2 (en) 2012-03-30 2015-03-03 Cubist Pharmaceuticals, Inc. Beta-lactamase inhibitors
TW201343645A (en) 2012-03-30 2013-11-01 Cubist Pharm Inc 1,3,4-oxadiazole and 1,3,4-thiadiazole β-lactamase inhibitors
KR20150003777A (en) 2012-03-30 2015-01-09 큐비스트 파마슈티컬즈 인코포레이티드 ISOXAZOLE β-LACTAMASE INHIBITORS
US8916709B2 (en) 2012-03-30 2014-12-23 Cubist Pharmaceuticals, Inc. 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors
AR090539A1 (en) * 2012-04-02 2014-11-19 Astrazeneca Ab INHIBITING COMPOUNDS OF B LACTAMASA
RU2693898C2 (en) 2012-05-30 2019-07-05 Мейдзи Сейка Фарма Ко., Лтд. Novel beta-lactamase inhibitor and method for production thereof
BR112015003592B1 (en) * 2012-08-25 2020-04-14 Wockhardt Ltd 1,6-diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections
JPWO2014069351A1 (en) 2012-11-01 2016-09-08 株式会社カネカ Method for producing optically active bicyclic urea compound
UA111925C2 (en) 2012-12-11 2016-06-24 Федора Фармасьютікалз Інк. BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS
CN104685061B (en) 2013-02-19 2018-05-01 株式会社Api L-lysine hydroxylase, method for producing hydroxy-L-lysine and method for producing hydroxy-L-2-pipericolic acid using the L-lysine hydroxylase
CA2904089C (en) * 2013-03-08 2017-05-02 Wockhardt Limited A process for sodium salt of (2s, 5r)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane
BR112015021332B1 (en) * 2013-03-08 2020-06-30 Wockhardt Limited sodium salt of (2s, 5r) -6-benzyloxy-7-oxo-1,6-diaza-bicyclo [3.2.1] octane-2-carboxylic and its preparation
US9120795B2 (en) 2013-03-14 2015-09-01 Cubist Pharmaceuticals, Inc. Crystalline form of a β-lactamase inhibitor
AU2014278556B2 (en) 2013-06-10 2018-07-19 Merck Sharp & Dohme Llc Preparation of tert-butyl 4-((1R,2S,5R)-6- (benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2- carboxamido)piperidine-1-carboxylate
DK3050883T3 (en) 2013-09-24 2020-05-25 Meiji Seika Pharma Co Ltd PROCEDURE FOR THE PREPARATION OF DIAZABICYCLOOCTAND DERIVATIVES AND INTERMEDIATES
US9120796B2 (en) 2013-10-02 2015-09-01 Cubist Pharmaceuticals, Inc. B-lactamase inhibitor picoline salt
EP3613740A1 (en) 2013-10-08 2020-02-26 Meiji Seika Pharma Co., Ltd. Preparation of a diazabicyclooctane derivative
US9434728B1 (en) 2013-10-11 2016-09-06 Wockhardt Limited Nitrogen containing compounds and their use
EP3096754B1 (en) 2014-01-22 2018-08-29 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
US9839642B2 (en) 2014-05-09 2017-12-12 Merck Sharp & Dohme Corp. Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
KR102542392B1 (en) * 2014-11-17 2023-06-09 엔타시스 테라퓨틱스 리미티드 Combination therapy for treatment of resistant bacterial infections
ES2812848T3 (en) 2014-12-02 2021-03-18 Merck Sharp & Dohme Process for the preparation of tert-butyl 4 - ((2S, 5R) -6- (benzyloxy) -7-oxo-1,6-diazabicyclo [3.2.1] octane-2-carboxamido) piperidine-1-carboxylate and analogues of the same
RU2732129C2 (en) 2014-12-05 2020-09-11 Мейдзи Сейка Фарма Ко., Лтд. Method of producing crystals of a diazabicyclooctane derivative and a stable lyophilized preparation
US10667737B2 (en) 2015-03-23 2020-06-02 International Business Machines Corporation Monitoring a person for indications of a brain injury
EP3091018A1 (en) * 2015-05-07 2016-11-09 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
CA2983674A1 (en) * 2015-05-07 2016-11-10 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
WO2016206101A1 (en) 2015-06-26 2016-12-29 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
WO2017002089A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002087A1 (en) 2015-07-02 2017-01-05 Wockhardtlimited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002086A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002083A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
US10265326B2 (en) 2015-08-10 2019-04-23 Sandoz Ag Form C of avibactam sodium
WO2017037607A1 (en) 2015-09-01 2017-03-09 Wockhardt Limited (aminomethylidene)amino-substituted (2s,5r)-6-(sulfonyl)-7-oxo-1,6-diazabicyclo[3.2.1 ]octane-2-carboxamide derivatives with antibacterial activity
EP3281942A4 (en) 2015-09-16 2018-08-15 Xuanzhu Pharma Co., Ltd. B-lactamase inhibitor and application thereof
CA3000087A1 (en) 2015-10-02 2017-04-06 Legochem Biosciences, Inc. Compositions and methods for inhibiting beta-lactamase
US10954539B2 (en) 2015-10-02 2021-03-23 Api Corporation Method for producing hydroxy-L-pipecolic acid
WO2017081615A1 (en) 2015-11-09 2017-05-18 Wockhardt Limited 7-oxo -6-(sulfooxy)- 1,6-diazabicyclo [3.2.1] octane containing compounds and their use in treatment of bacterial infections
CN106749242B (en) * 2015-11-23 2021-04-02 上海医药工业研究院 The preparation method of avibactam intermediate
WO2017136254A1 (en) 2016-02-04 2017-08-10 Merck Sharp & Dohme Corp. Methods of preparing hydroxylamine derivatives useful in the preparation of anti-infective agents
CN105753867B (en) * 2016-03-24 2018-03-27 齐鲁制药有限公司 A kind of preparation method of improved AVM hereinafter Batan sodium midbody compound
ES2734773T3 (en) 2016-05-27 2019-12-11 Valoralia I Mas D Sl Dihydrooxadiazine compounds to treat infections and cancer
CN106279163A (en) * 2016-08-12 2017-01-04 上海龙翔生物医药开发有限公司 A kind of method synthesizing A Wei Batan and intermediate optical isomer thereof
WO2018037124A1 (en) 2016-08-26 2018-03-01 Sandoz Ag Avibactam free acid
CN114591223B (en) 2016-09-16 2025-01-24 恩塔西斯治疗有限公司 β-lactamase inhibitor compounds
JOP20190061A1 (en) 2016-09-28 2019-03-26 Novartis Ag Beta-lactamase inhibitors
EP3301094A1 (en) * 2016-09-30 2018-04-04 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
CN106699756B (en) * 2016-12-30 2019-10-29 淄博鑫泉医药技术服务有限公司 The synthetic method of beta lactamase restrainer AVM hereinafter Batan
KR20190115062A (en) * 2017-02-06 2019-10-10 무타빌리스 New heterocyclic compounds and their use for the treatment or prevention of bacterial infections
NZ758200A (en) 2017-05-08 2025-12-19 Entasis Therapeutics Inc Compounds and methods for treating bacterial infections
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
WO2018234962A1 (en) 2017-06-20 2018-12-27 Wockhardt Limited PROCESS FOR O-SULFONATION OF 1,6-DIAZABICYCLO [3.2.1] OCTANE COMPOUNDS
US11207312B2 (en) 2017-07-17 2021-12-28 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors and methods of use thereof
KR102455390B1 (en) 2017-10-02 2022-10-17 아릭사 파마슈티컬스 인코포레이티드 Aztreonam derivatives and uses thereof
CN109678856B (en) * 2017-10-18 2020-09-25 新发药业有限公司 Preparation method of avibactam intermediate
CN111373033A (en) 2017-11-23 2020-07-03 豪夫迈·罗氏有限公司 Proline hydroxylase and related uses, methods and products
CN109956941B (en) * 2017-12-25 2020-08-04 新发药业有限公司 Simple preparation method of abamectin
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
SG11202101255UA (en) 2018-08-09 2021-03-30 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
ES2991492T3 (en) 2018-10-01 2024-12-03 Arixa Pharmaceuticals Inc Relebactam derivatives and their uses
CN111072660B (en) * 2018-10-22 2021-05-18 新发药业有限公司 Simple preparation method of rilibatan
AU2020237440B2 (en) 2019-03-12 2022-10-20 Arixa Pharmaceuticals, Inc. Crystalline form of an avibactam derivative
US11565999B2 (en) 2019-04-25 2023-01-31 Arixa Pharmaceuticals, Inc. Methods of synthesizing aztreonam derivatives
CN110078728B (en) * 2019-05-23 2020-10-23 江西富祥药业股份有限公司 Abamebactam intermediate, preparation method and application thereof
WO2021106864A1 (en) * 2019-11-25 2021-06-03 Eisai R&D Management Co., Ltd. Process for the preparation of producing pyrazolo[1,5-a] pyrimidine derivatives
EP4146650B1 (en) 2020-09-01 2026-01-21 Ningxia Academy of Agriculture and Forestry Sciences Beta-lactamase inhibitors and their preparation
US12410166B2 (en) 2021-05-07 2025-09-09 Ningxia Academy Of Agriculture And Forestry Sciences Sulfonylamidine substituted compounds and their use as beta-lactamase inhibitors
US11814385B2 (en) 2021-06-25 2023-11-14 University Of South Florida Small molecule inhibitors targeting Clostridioides difficile sporulation
KR20240041506A (en) 2022-09-23 2024-04-01 주식회사 경보제약 Stable monohydrate form of avibactam sodium and manufacturaing method thereof
WO2025027521A1 (en) 2023-08-01 2025-02-06 Fresenius Kabi Oncology Ltd. An improved process for the preparation of avibactam and intermediate thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4939678B1 (en) * 1968-05-06 1974-10-28
US4024147A (en) * 1972-06-30 1977-05-17 John Wyeth & Brother Limited Heterocyclic compounds
US4049821A (en) * 1976-05-12 1977-09-20 A. H. Robins Company, Inc. Method of treating allergy
EP0260057A3 (en) * 1986-09-02 1989-02-01 The University Of Melbourne 2-oxo-4-carboxy-pyrimidines
JPS63119471A (en) * 1986-09-02 1988-05-24 ザ・ユニバーシテイ・オブ・メルボルン 2-oxo-4-carboxy-pyrimidine
HUT74682A (en) * 1993-12-29 1997-01-28 Pfizer Diazabicyclic neurokinin antagonists and pharmaceutical compositions containing them
TW358097B (en) * 1996-05-24 1999-05-11 Hoffmann La Roche Beta-lactams and their process and pharmaceutical compositions
HUP0001741A3 (en) * 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
CN1523015A (en) * 1997-02-10 2004-08-25 �Ʒ� 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines
US6060585A (en) * 1997-03-04 2000-05-09 Wisconsin Alumni Research Foundation β-polypeptide foldamers of well-defined secondary structure
KR100207096B1 (en) * 1997-07-08 1999-07-15 이명환 Process for the preparation of cisapride
DE69906059D1 (en) * 1998-04-20 2003-04-24 Fujisawa Pharmaceutical Co ANTHRANILIC ACID DERIVATIVES AS INHIBITORS OF C-GMP PHOSPHODIESTERASE
GB9817029D0 (en) * 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds
FR2784682B1 (en) * 1998-10-15 2002-12-06 Hoechst Marion Roussel Inc NOVEL 2-HALOGEN DERIVATIVES OF 5-0-DESOSAMINYLERYTHRONOLIDE A, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS
AU2055500A (en) * 1998-12-23 2000-07-31 Eli Lilly And Company Aromatic amides
TR200101903T2 (en) * 1999-01-02 2001-11-21 Aventis Pharma Deutschland Gmbh New malonic acid derivatives, their preparation processes.
FR2812635B1 (en) * 2000-08-01 2002-10-11 Aventis Pharma Sa NOVEL HETEROCYCLIC COMPOUNDS, PREPARATION AND USE AS MEDICAMENTS IN PARTICULAR AS ANTI-BACTERIALS
FR2835186B1 (en) * 2002-01-28 2006-10-20 Aventis Pharma Sa NOVEL HETEROCYCLIC COMPOUNDS ACTIVE AS BETA-LACTAMASES INHIBITORS

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