ECSP034616A - NEW DERIVATIVES OF PIRAZOLOPIRIDINA SUBSTITUTED WITH PIRIDINE - Google Patents
NEW DERIVATIVES OF PIRAZOLOPIRIDINA SUBSTITUTED WITH PIRIDINEInfo
- Publication number
- ECSP034616A ECSP034616A EC2003004616A ECSP034616A ECSP034616A EC SP034616 A ECSP034616 A EC SP034616A EC 2003004616 A EC2003004616 A EC 2003004616A EC SP034616 A ECSP034616 A EC SP034616A EC SP034616 A ECSP034616 A EC SP034616A
- Authority
- EC
- Ecuador
- Prior art keywords
- pirazolopiridina
- piridine
- substituted
- new derivatives
- designates
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 206010020852 Hypertonia Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 abstract 1
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 abstract 1
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 abstract 1
- 230000002425 cardiocirculatory effect Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 239000000021 stimulant Substances 0.000 abstract 1
- 230000009424 thromboembolic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
En la que R1 designa 4-piridina o 3 piridinilo R2 designa H. NH2 o halógeno, así como sales isomeros e hidratos de los mismos como estimulantes de la guanilatociclasa soluble y para el uso como agentes para el tratamiento de enfermedades cardiocirculatorias, hipertonia, trastornos tromboembolicos e isquemias disfunción sexual o inflamaciones así como para el tratamiento de enfermedades del sistema nervioso central.In which R1 designates 4-pyridine or 3 pyridinyl R2 designates H. NH2 or halogen, as well as isomeric salts and hydrates thereof as stimulants of soluble guanylate cyclase and for use as agents for the treatment of cardiocirculatory diseases, hypertonia, disorders thromboembolic and ischemia sexual dysfunction or inflammation as well as for the treatment of diseases of the central nervous system.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10057753 | 2000-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP034616A true ECSP034616A (en) | 2003-06-25 |
Family
ID=7664122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2003004616A ECSP034616A (en) | 2000-11-22 | 2003-05-21 | NEW DERIVATIVES OF PIRAZOLOPIRIDINA SUBSTITUTED WITH PIRIDINE |
Country Status (12)
| Country | Link |
|---|---|
| KR (1) | KR20030065519A (en) |
| DE (2) | DE10131987A1 (en) |
| DO (1) | DOP2001000291A (en) |
| EC (1) | ECSP034616A (en) |
| GT (1) | GT200100235A (en) |
| HN (1) | HN2001000261A (en) |
| MY (1) | MY127212A (en) |
| PE (1) | PE20020581A1 (en) |
| RU (1) | RU2003118584A (en) |
| SV (1) | SV2003000743A (en) |
| UA (1) | UA74404C2 (en) |
| ZA (1) | ZA200303887B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102485724B (en) * | 2010-12-06 | 2015-08-12 | 中国人民解放军军事医学科学院毒物药物研究所 | Substituted thiophene base pyrazolo-pyridines and medicinal use thereof |
| ES2603028T3 (en) | 2011-11-25 | 2017-02-23 | Adverio Pharma Gmbh | Procedure for the preparation of (Z) -alpha-fluoro-beta-amino-acrylaldehydes |
| EP3525779B1 (en) * | 2016-10-11 | 2024-06-05 | Bayer Pharma Aktiengesellschaft | Combination containing the sgc stimulator vericuguat and the mineralcorticoid receptor antagonist finerenone |
-
2001
- 2001-07-02 DE DE10131987A patent/DE10131987A1/en not_active Withdrawn
- 2001-11-09 KR KR10-2003-7006853A patent/KR20030065519A/en not_active Withdrawn
- 2001-11-09 UA UA2003065752A patent/UA74404C2/en unknown
- 2001-11-09 DE DE50106655T patent/DE50106655D1/en not_active Expired - Lifetime
- 2001-11-09 RU RU2003118584/04A patent/RU2003118584A/en not_active Application Discontinuation
- 2001-11-20 DO DO2001000291A patent/DOP2001000291A/en unknown
- 2001-11-20 MY MYPI20015302A patent/MY127212A/en unknown
- 2001-11-21 PE PE2001001161A patent/PE20020581A1/en not_active Application Discontinuation
- 2001-11-21 HN HN2001000261A patent/HN2001000261A/en unknown
- 2001-11-21 SV SV2001000743A patent/SV2003000743A/en unknown
- 2001-11-22 GT GT200100235A patent/GT200100235A/en unknown
-
2003
- 2003-05-19 ZA ZA200303887A patent/ZA200303887B/en unknown
- 2003-05-21 EC EC2003004616A patent/ECSP034616A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UA74404C2 (en) | 2005-12-15 |
| MY127212A (en) | 2006-11-30 |
| RU2003118584A (en) | 2004-12-20 |
| PE20020581A1 (en) | 2002-07-13 |
| GT200100235A (en) | 2002-06-25 |
| KR20030065519A (en) | 2003-08-06 |
| DE10131987A1 (en) | 2002-05-23 |
| DOP2001000291A (en) | 2002-12-15 |
| HN2001000261A (en) | 2002-01-30 |
| ZA200303887B (en) | 2004-06-21 |
| SV2003000743A (en) | 2003-01-13 |
| DE50106655D1 (en) | 2005-08-04 |
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