ECSP044944A - SUBSTITUTED DERIVATIVES OF 4-AMINOCICLOHEXANOL - Google Patents

SUBSTITUTED DERIVATIVES OF 4-AMINOCICLOHEXANOL

Info

Publication number
ECSP044944A
ECSP044944A EC2004004944A ECSP044944A ECSP044944A EC SP044944 A ECSP044944 A EC SP044944A EC 2004004944 A EC2004004944 A EC 2004004944A EC SP044944 A ECSP044944 A EC SP044944A EC SP044944 A ECSP044944 A EC SP044944A
Authority
EC
Ecuador
Prior art keywords
substituted derivatives
aminociclohexanol
aminocyclohexanol
medicaments
manufacture
Prior art date
Application number
EC2004004944A
Other languages
Spanish (es)
Inventor
Hagen Heinrich Hennies
Bernd Sundermann
Stephan Wnendt
Babette-Yvonne Koegel
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of ECSP044944A publication Critical patent/ECSP044944A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención dice relación con derivados sustituidos de 4-aminociclohexanol, el proceso para su elaboración, medicamentos que contienen esta combinación y el uso de derivados sustituidos de 4-aminociclohexanol para la fabricación de medicamentos para el tratamiento de diversas indicaciones, en especial del dolor.The present invention relates to substituted derivatives of 4-aminocyclohexanol, the process for its preparation, medicaments containing this combination and the use of substituted derivatives of 4-aminocyclohexanol for the manufacture of medicaments for the treatment of various indications, especially pain .

EC2004004944A 2001-07-17 2004-01-15 SUBSTITUTED DERIVATIVES OF 4-AMINOCICLOHEXANOL ECSP044944A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10135637A DE10135637A1 (en) 2001-07-17 2001-07-17 New substituted 4-aminocyclohexanol derivatives, are ORL1 receptor ligands useful e.g. for treating anxiety, depression, epilepsy, Alzheimer's disease, cardiovascular disease or especially pain

Publications (1)

Publication Number Publication Date
ECSP044944A true ECSP044944A (en) 2004-02-26

Family

ID=7692669

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004004944A ECSP044944A (en) 2001-07-17 2004-01-15 SUBSTITUTED DERIVATIVES OF 4-AMINOCICLOHEXANOL

Country Status (2)

Country Link
DE (1) DE10135637A1 (en)
EC (1) ECSP044944A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10153346A1 (en) 2001-10-29 2004-04-22 Grünenthal GmbH Substituted indoles
DE102006033109A1 (en) 2006-07-18 2008-01-31 Grünenthal GmbH Substituted heteroaryl derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115589A (en) * 1977-05-17 1978-09-19 The Upjohn Company Compounds, compositions and method of use
US4366172A (en) * 1977-09-29 1982-12-28 The Upjohn Company 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use
US4212878A (en) * 1978-01-26 1980-07-15 The Upjohn Company Phenylacetamide derivative analgesics
US4346101A (en) * 1980-12-08 1982-08-24 The Upjohn Company Benzamide derivative analgesics
DE3924304A1 (en) * 1989-07-22 1991-01-31 Bayer Ag NEW FLUORINATED CYCLOHEXIDEERIVATES, METHOD AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION AND USE OF THE NEW FLUORATED CYCLOHEXE DERIVATIVES AS FUNGICIDES AND INTERMEDIATE PRODUCTS
US5304479A (en) * 1991-12-06 1994-04-19 Diagnostic Reagents, Inc. Phencyclidine compounds and assays for its determination
US5239110A (en) * 1992-12-30 1993-08-24 Sterling Winthrop, Inc. Phenylcyclohexanol derivatives as agents for treating CNS disorders

Also Published As

Publication number Publication date
DE10135637A1 (en) 2003-02-06

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