ECSP044958A - VIRAL POLYMERASE INHIBITORS - Google Patents

VIRAL POLYMERASE INHIBITORS

Info

Publication number
ECSP044958A
ECSP044958A EC2004004958A ECSP044958A ECSP044958A EC SP044958 A ECSP044958 A EC SP044958A EC 2004004958 A EC2004004958 A EC 2004004958A EC SP044958 A ECSP044958 A EC SP044958A EC SP044958 A ECSP044958 A EC SP044958A
Authority
EC
Ecuador
Prior art keywords
polymerase inhibitors
viral polymerase
nr22c
same definition
defined above
Prior art date
Application number
EC2004004958A
Other languages
Spanish (es)
Inventor
Pierre Louis Beaulieu
Eric Jolicoeur
Marc Andre Poupart
Sylvie Goulet
Jean Rancourt
Martin Poirier
Gulrez Fazal
George Kukolj
James Gillard
Original Assignee
Boehringer Ingelheim Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Canada Ltd filed Critical Boehringer Ingelheim Canada Ltd
Publication of ECSP044958A publication Critical patent/ECSP044958A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Un isómero, enantiómero, diastereoisómero o tautómero de un compuestos, representado por la fórmula I: en la que A es O, S, NR1 o CR1, donde R1 se ha definido en esta memoria; representa o un enlace sencillo o uno doble; R2 se selecciona entre: H. halógeno, R21, OR21, SR21, COOR21, SO2N(R22)2, N(R22)2, CON(R22)2, NR22C(O)R22 o NR22C(O)NR22 donde R21 y cada R22 se ha definido en esta memoria; B es NR3 o CR3, con la condición de que uno de A o B es o CR1 o CR3, donde R3 se ha definido en esta memoria; K es N o CR4, donde R4 se ha definido en esta memoria; L es N o CR5, donde R5 tiene la misma definición que R4 definido antes; M es N o CR7, donde R7 tiene la misma definición que R4 definido antes; Y1 es O o S; Z es N(R6a)R6 o OR6, donde R6a es H o alquilo o NR61R62 donde R61 y R62 se ha definido en esta memoria; una de sus sales o uno de sus derivados, como un inhibidor de polimerasa NS5B de lHCV.An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A is O, S, NR1 or CR1, where R1 has been defined herein; represents either a single or a double bond; R2 is selected from: H. halogen, R21, OR21, SR21, COOR21, SO2N (R22) 2, N (R22) 2, CON (R22) 2, NR22C (O) R22 or NR22C (O) NR22 where R21 and each R22 has been defined herein; B is NR3 or CR3, with the proviso that one of A or B is either CR1 or CR3, where R3 has been defined herein; K is N or CR4, where R4 has been defined herein; L is N or CR5, where R5 has the same definition as R4 defined above; M is N or CR7, where R7 has the same definition as R4 defined above; Y1 is O or S; Z is N (R6a) R6 or OR6, where R6a is H or alkyl or NR61R62 where R61 and R62 has been defined herein; one of its salts or one of its derivatives, such as an NS5B polymerase inhibitor of lHCV.

EC2004004958A 2001-07-25 2004-01-23 VIRAL POLYMERASE INHIBITORS ECSP044958A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30767401P 2001-07-25 2001-07-25

Publications (1)

Publication Number Publication Date
ECSP044958A true ECSP044958A (en) 2004-03-23

Family

ID=34572608

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004004958A ECSP044958A (en) 2001-07-25 2004-01-23 VIRAL POLYMERASE INHIBITORS

Country Status (4)

Country Link
CN (1) CN101302182A (en)
EC (1) ECSP044958A (en)
UA (2) UA85366C2 (en)
ZA (2) ZA200400122B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20120773A1 (en) * 2009-03-27 2012-07-19 Presidio Pharmaceuticals Inc FUSED TRICYCLIC RINGS REPLACED AS HEPATITIS C VIRUS INHIBITORS

Also Published As

Publication number Publication date
UA101465C2 (en) 2013-04-10
ZA200400240B (en) 2004-11-01
ZA200400122B (en) 2004-11-03
CN101302182A (en) 2008-11-12
UA85366C2 (en) 2009-01-26

Similar Documents

Publication Publication Date Title
CO5650161A2 (en) VIRAL POLYMERASE INHIBITORS
DE60225709D1 (en) AMINOBENZAMID DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3
CO5580777A2 (en) INHIBITORS OF HYDROXYPYRIMIDINONE CARBOXAMIDE N-SUBSTITUTES OF INTEGRATED HIV
ES2567571T3 (en) C-glycoside derivatives and salts thereof
ECSP077171A (en) VIRAL POLYMERASE INHIBITORS
ATE346070T1 (en) PURINE DERIVATIVES AS KINASE INHIBITORS
BRPI0506817A (en) selective kinase inhibitors
NO20040100L (en) New compounds such as anti-inflammatory, immunomodulatory and anti-proliferative agents
MY136789A (en) Metalloproteinase inhibitors
SV2004001414A (en) INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION WATERFALL. PC20535
AR049089A1 (en) DERIVATIVES OF ADAMANTIL PIRROLIDIN -2- ONA AS INHIBITORS OF 11-BETA HYDROXIESTEROID DEHYDROGENASE
UY29702A1 (en) MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS
EA200901463A1 (en) VIRAL POLYMERASE INHIBITORS
TNSN07348A1 (en) Thiadiazole substituted coumarin derivatives and their use as leukotriene biosynthesis inhibitor
CY1106247T1 (en) THIOPHEN- AND THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS
DK1377579T3 (en) Acyl and sulfonyl derivatives of 6,9-disubstituted-2 (trans-1,4-diaminocyclohexyl) purines and their use as antiproliferative agents
AR026352A1 (en) IMIDAZOPIRIDINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE VII.
ATE411287T1 (en) NEW METALPROTEINASE INHIBITORS
DE60336735D1 (en) NEW BIOLOGICAL MOLEKÜ LE
ECSP044958A (en) VIRAL POLYMERASE INHIBITORS
AR054583A1 (en) PANTOPRAZOL ISOTOPICALLY REPLACED
NO20050871L (en) 6-amino-1H-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
DE60225019D1 (en) Non-nucleosidic inhibitors of the reverse transcriptase
ATE308541T1 (en) 2-AMINO-4-HETEROARYLETHYL-THIAZOLINE DERIVATIVES AND THEIR USE AS INHIBITERS OF INDUCIBLE NO-SYNTHASE
PE38397A1 (en) COMBINED THERAPY FOR HIV INFECTION