ECSP045045A - PHARMACEUTICAL FORMULATIONS OF CONTROLLED RELEASE INCLUDING 4-AMINO-6,7-DIMETOXI-2- (5-METHANOSULPHONAMIDE-1,2,3,4-TETRAHYDROISOQUINOL-2-IL) -5- (2-PIRIDIL) QUINAZOLINA - Google Patents
PHARMACEUTICAL FORMULATIONS OF CONTROLLED RELEASE INCLUDING 4-AMINO-6,7-DIMETOXI-2- (5-METHANOSULPHONAMIDE-1,2,3,4-TETRAHYDROISOQUINOL-2-IL) -5- (2-PIRIDIL) QUINAZOLINAInfo
- Publication number
- ECSP045045A ECSP045045A ECSP045045A ECSP045045A EC SP045045 A ECSP045045 A EC SP045045A EC SP045045 A ECSP045045 A EC SP045045A EC SP045045 A ECSP045045 A EC SP045045A
- Authority
- EC
- Ecuador
- Prior art keywords
- amino
- tetrahydroisoquinol
- controlled release
- pharmaceutically acceptable
- methanosulphonamide
- Prior art date
Links
- 238000013270 controlled release Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000012738 dissolution medium Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- OLYXPBZBZBVRGD-UHFFFAOYSA-N n-[2-(4-amino-6,7-dimethoxy-5-pyridin-2-ylquinazolin-2-yl)-3,4-dihydro-1h-isoquinolin-5-yl]methanesulfonamide Chemical compound COC=1C(OC)=CC2=NC(N3CC4=C(C(=CC=C4)NS(C)(=O)=O)CC3)=NC(N)=C2C=1C1=CC=CC=N1 OLYXPBZBZBVRGD-UHFFFAOYSA-N 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La invención proporciona una formulación farmacéutica de liberación controlada para administración oral que comprende 4-amino-6,7-dimetoxi-2-(5-metanosulfonamido-1,2,3,4-tetrahidroisoquinol-2-il)-5-(2-piridil)quinazolina o una sal farmacéuticamente aceptable de la misma; y un adyuvante, diluyente o vehículo farmacéuticamente aceptable; caracterizada porque la formulación está adaptada para liberar al menos un 50% en peso de la 4-amino-6,7-dimetoxi-2-(5-metanosulonamido-1,2,3,4-tetrahidro-isoquinol-2-il)-5-(2-piridil)quinazolina, o la sal farmacéuticamente aceptable de la misma, después de 6 horas en el Aparato I descrito en la Farmacopea de Estados Unidos 24 (2000), páginas 1941-193,que tiene recipientes de 1 litro, cestas de malla 40 (orificios de 0,4 mm), una velocidad de rotación de 100 rpm y un medio de disolución que consta de 900 ml de ácido clorhídrico 0, 01 M que contiene cloruro sódico al 0.7% p/v a 37° C.The invention provides a controlled release pharmaceutical formulation for oral administration comprising 4-amino-6,7-dimethoxy-2- (5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl) -5- (2 -pyridyl) quinazoline or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable adjuvant, diluent or carrier; characterized in that the formulation is adapted to release at least 50% by weight of 4-amino-6,7-dimethoxy-2- (5-methanesulonamido-1,2,3,4-tetrahydro-isoquinol-2-yl) -5- (2-pyridyl) quinazoline, or the pharmaceutically acceptable salt thereof, after 6 hours in the Apparatus I described in the United States Pharmacopoeia 24 (2000), pages 1941-193, which has 1 liter containers , 40 mesh baskets (0.4 mm holes), a rotation speed of 100 rpm and a dissolution medium consisting of 900 ml of 0.01 M hydrochloric acid containing 0.7% sodium chloride w / w 37 ° C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP045045 ECSP045045A (en) | 2004-04-02 | 2004-04-02 | PHARMACEUTICAL FORMULATIONS OF CONTROLLED RELEASE INCLUDING 4-AMINO-6,7-DIMETOXI-2- (5-METHANOSULPHONAMIDE-1,2,3,4-TETRAHYDROISOQUINOL-2-IL) -5- (2-PIRIDIL) QUINAZOLINA |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP045045 ECSP045045A (en) | 2004-04-02 | 2004-04-02 | PHARMACEUTICAL FORMULATIONS OF CONTROLLED RELEASE INCLUDING 4-AMINO-6,7-DIMETOXI-2- (5-METHANOSULPHONAMIDE-1,2,3,4-TETRAHYDROISOQUINOL-2-IL) -5- (2-PIRIDIL) QUINAZOLINA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045045A true ECSP045045A (en) | 2004-04-28 |
Family
ID=40435088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP045045 ECSP045045A (en) | 2004-04-02 | 2004-04-02 | PHARMACEUTICAL FORMULATIONS OF CONTROLLED RELEASE INCLUDING 4-AMINO-6,7-DIMETOXI-2- (5-METHANOSULPHONAMIDE-1,2,3,4-TETRAHYDROISOQUINOL-2-IL) -5- (2-PIRIDIL) QUINAZOLINA |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP045045A (en) |
-
2004
- 2004-04-02 EC ECSP045045 patent/ECSP045045A/en unknown
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