ECSP045091A - AMIDAS OF ANTRANILIC ACID AND PHARMACEUTICAL USE OF THE SAME - Google Patents
AMIDAS OF ANTRANILIC ACID AND PHARMACEUTICAL USE OF THE SAMEInfo
- Publication number
- ECSP045091A ECSP045091A ECSP045091A ECSP045091A EC SP045091 A ECSP045091 A EC SP045091A EC SP045091 A ECSP045091 A EC SP045091A EC SP045091 A ECSP045091 A EC SP045091A
- Authority
- EC
- Ecuador
- Prior art keywords
- carbon atoms
- treatment
- alkyl
- alkenyl
- formula
- Prior art date
Links
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 title abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 208000017442 Retinal disease Diseases 0.000 abstract 2
- 206010038923 Retinopathy Diseases 0.000 abstract 2
- 206010064930 age-related macular degeneration Diseases 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 208000002780 macular degeneration Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001613 neoplastic effect Effects 0.000 abstract 2
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 2
- PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical class NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invención se refiere a derivados de amida de ácido antranílico de la fórmula (I), en donde Ar está representado por la sub-fórmula (Ia), en donde Ra representa H o alquilo inferior, R1 representa H o perfluoroalquilo inferior, y y R2 representa H, halógeno, alquilo de 2 a 7 átomos de carbono, alquenilo de 2 a 7 átomos de carbono, o alquinilo inferior; o Ar está representado por la subfórmula (Ib), y R1 representa perfluoroalquilo inferior, y R2 representa bromo, yodo, alquilo de 2 a 7 átomos de carbono, alquenilo de 2 a 7 átomos de carbono, o alquinilo inferior, o R1 representa H, y R2 representa flúor, bromo, yodo, etilo, alquilo de 5 a 7 átomos de carbono, alquenilo de 2 a 7 átomos de carbono, o alquinilo inferior; a N-óxidos y tautómeros de los mismos, y a sales de estas amidas de ácido antranílico, sus N-óxidos y tautómeros; a procesos para su preparación; a su aplicación en el tratamiento del cuerpo humano o animal, al uso de los mismos - solos o en combinación con uno o más compuestos farmacéuticamente activos diferentes - para el tratamiento en especial de una enfermedad neoplástica, tal como una enfermedad tumoral, de retinopatía o degeneración macular relacionada con la edad; a un método para el tratamiento de estas enfermedades en animales; y al uso de este compuesto - solo o en combinación con uno o más compuestos farmacéuticamente activos diferentes - para la fabricación de una preparación farmacéutica para el tratamiento de una enfermedad neoplástica, de retinopatía, o degeneración macular relacionada con la edad.The invention relates to anthranilic acid amide derivatives of the formula (I), wherein Ar is represented by the sub-formula (Ia), wherein Ra represents H or lower alkyl, R1 represents H or lower perfluoroalkyl, and and R2 represents H, halogen, alkyl of 2 to 7 carbon atoms, alkenyl of 2 to 7 carbon atoms, or lower alkynyl; or Ar is represented by sub-formula (Ib), and R1 represents lower perfluoroalkyl, and R2 represents bromine, iodine, alkyl of 2 to 7 carbon atoms, alkenyl of 2 to 7 carbon atoms, or lower alkynyl, or R1 represents H , and R2 represents fluorine, bromine, iodine, ethyl, alkyl of 5 to 7 carbon atoms, alkenyl of 2 to 7 carbon atoms, or lower alkynyl; to N-oxides and tautomers thereof, and to salts of these amides of anthranilic acid, their N-oxides and tautomers; to processes for its preparation; to its application in the treatment of the human or animal body, to the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment in particular of a neoplastic disease, such as a tumor, retinopathy or age-related macular degeneration; to a method for the treatment of these diseases in animals; and to the use of this compound - alone or in combination with one or more other pharmaceutically active compounds - for the manufacture of a pharmaceutical preparation for the treatment of a neoplastic disease, retinopathy, or age-related macular degeneration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP045091 ECSP045091A (en) | 2004-05-03 | 2004-05-03 | AMIDAS OF ANTRANILIC ACID AND PHARMACEUTICAL USE OF THE SAME |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP045091 ECSP045091A (en) | 2004-05-03 | 2004-05-03 | AMIDAS OF ANTRANILIC ACID AND PHARMACEUTICAL USE OF THE SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045091A true ECSP045091A (en) | 2004-06-28 |
Family
ID=40435099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP045091 ECSP045091A (en) | 2004-05-03 | 2004-05-03 | AMIDAS OF ANTRANILIC ACID AND PHARMACEUTICAL USE OF THE SAME |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP045091A (en) |
-
2004
- 2004-05-03 EC ECSP045091 patent/ECSP045091A/en unknown
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