ECSP045121A - RECEIVER AGONISTS ACTIVATED BY PEROXISOM PROLIFERATOR - Google Patents

RECEIVER AGONISTS ACTIVATED BY PEROXISOM PROLIFERATOR

Info

Publication number
ECSP045121A
ECSP045121A EC2004005121A ECSP045121A ECSP045121A EC SP045121 A ECSP045121 A EC SP045121A EC 2004005121 A EC2004005121 A EC 2004005121A EC SP045121 A ECSP045121 A EC SP045121A EC SP045121 A ECSP045121 A EC SP045121A
Authority
EC
Ecuador
Prior art keywords
alkyl
group
substituted
optionally
heteroaryl
Prior art date
Application number
EC2004005121A
Other languages
Spanish (es)
Inventor
Tracey Ann Gibson
Richard Duane Johnston
Nathan Bryan Mantlo
Richard Craig Thompson
Leonard Larry Winneroski
Yanping Xu
Xiaodong Wang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP045121A publication Critical patent/ECSP045121A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F210/00—Copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • C08F210/16—Copolymers of ethene with alpha-alkenes, e.g. EP rubbers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/42—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
    • C08F4/44—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
    • C08F4/60—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides together with refractory metals, iron group metals, platinum group metals, manganese, rhenium technetium or compounds thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F10/00—Homopolymers and copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F10/00—Homopolymers and copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • C08F10/02—Ethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/02—Carriers therefor
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/42—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
    • C08F4/44—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
    • C08F4/60—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides together with refractory metals, iron group metals, platinum group metals, manganese, rhenium technetium or compounds thereof
    • C08F4/62—Refractory metals or compounds thereof
    • C08F4/64—Titanium, zirconium, hafnium or compounds thereof
    • C08F4/659—Component covered by group C08F4/64 containing a transition metal-carbon bond
    • C08F4/65912—Component covered by group C08F4/64 containing a transition metal-carbon bond in combination with an organoaluminium compound
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/42—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
    • C08F4/44—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
    • C08F4/60—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides together with refractory metals, iron group metals, platinum group metals, manganese, rhenium technetium or compounds thereof
    • C08F4/62—Refractory metals or compounds thereof
    • C08F4/64—Titanium, zirconium, hafnium or compounds thereof
    • C08F4/659—Component covered by group C08F4/64 containing a transition metal-carbon bond
    • C08F4/65916—Component covered by group C08F4/64 containing a transition metal-carbon bond supported on a carrier, e.g. silica, MgCl2, polymer
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/42—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
    • C08F4/44—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
    • C08F4/60—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides together with refractory metals, iron group metals, platinum group metals, manganese, rhenium technetium or compounds thereof
    • C08F4/62—Refractory metals or compounds thereof
    • C08F4/64—Titanium, zirconium, hafnium or compounds thereof
    • C08F4/659—Component covered by group C08F4/64 containing a transition metal-carbon bond
    • C08F4/6592—Component covered by group C08F4/64 containing a transition metal-carbon bond containing at least one cyclopentadienyl ring, condensed or not, e.g. an indenyl or a fluorenyl ring
    • C08F4/65922—Component covered by group C08F4/64 containing a transition metal-carbon bond containing at least one cyclopentadienyl ring, condensed or not, e.g. an indenyl or a fluorenyl ring containing at least two cyclopentadienyl rings, fused or not
    • C08F4/65925—Component covered by group C08F4/64 containing a transition metal-carbon bond containing at least one cyclopentadienyl ring, condensed or not, e.g. an indenyl or a fluorenyl ring containing at least two cyclopentadienyl rings, fused or not two cyclopentadienyl rings being mutually non-bridged

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos representados por la siguiente fórmula estructural y sales, solvatos e hidratos farmacéuticamente aceptables de los mismos, en la que: (a) R1 se selecciona entre el grupo compuesto por hidrógeno, un grupo sustituido o no sustituido seleccionado entre alquilo C1-C8, aril-alquilo C0-4, heteroaril-alquilo C0-4, cicloalquilaril C3-C6-alquilo C0-2, y -CH2-C(O)-R17-R18, donde R17 es O, o NH y R18 es bencilo opcionalmente sustituido; (b) R2 es H o un grupo sustituido o no sustituido seleccionado entre el grupo compuesto por alquilo C1-C6, alquenilo C1-C6, aril-alquilo C0-4, heteroaril-alquilo C0-4, alquil C1-C4 sulfonamida, alquil C1-C4 amida, OR10 y cicloalquilo C3-C6; (c) W es O, o S; (d) X es un engarce alquileno C1-C5 opcionalmente sustituido donde un átomo de carbono del engarce se puede sustituir opcionalmente con O, NH, S y opcionalmente dos carbonos juntos pueden formar un doble enlace; (e) Y se selecciona entre el grupo compuesto por C, O, S, NH y un enlace simple; y (f) E se selecciona entre el grupo compuesto por C(R3)(R4)A, A y un grupo sustituido o no sustituido seleccionado entre el grupo compuesto por (CH2)nCOOR19.The present invention relates to compounds represented by the following structural formula and pharmaceutically acceptable salts, solvates and hydrates thereof, in which: (a) R1 is selected from the group consisting of hydrogen, a substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-4 alkyl, heteroaryl-C0-4 alkyl, C3-C6 cycloalkylaryl-C0-2 alkyl, and -CH2-C (O) -R17-R18, where R17 is O, or NH and R18 is optionally substituted benzyl; (b) R2 is H or a substituted or unsubstituted group selected from the group consisting of C1-C6 alkyl, C1-C6 alkenyl, aryl-C0-4 alkyl, heteroaryl-C0-4 alkyl, C1-C4 alkyl sulfonamide, alkyl C1-C4 amide, OR10 and C3-C6 cycloalkyl; (c) W is O, or S; (d) X is an optionally substituted C1-C5 alkylene linker where a carbon atom of the linker may optionally be substituted with O, NH, S and optionally two carbons together may form a double bond; (e) Y is selected from the group consisting of C, O, S, NH and a single bond; and (f) E is selected from the group consisting of C (R3) (R4) A, A and a substituted or unsubstituted group selected from the group consisting of (CH2) nCOOR19.

EC2004005121A 2001-11-30 2004-05-26 RECEIVER AGONISTS ACTIVATED BY PEROXISOM PROLIFERATOR ECSP045121A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33445601P 2001-11-30 2001-11-30

Publications (1)

Publication Number Publication Date
ECSP045121A true ECSP045121A (en) 2004-07-23

Family

ID=23307289

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005121A ECSP045121A (en) 2001-11-30 2004-05-26 RECEIVER AGONISTS ACTIVATED BY PEROXISOM PROLIFERATOR

Country Status (12)

Country Link
US (1) US20050003950A1 (en)
EP (1) EP1461151A4 (en)
JP (1) JP2005511802A (en)
KR (1) KR20050033542A (en)
CN (2) CN100584462C (en)
AR (1) AR036903A1 (en)
AU (1) AU2002365867A1 (en)
BR (1) BR0214554A (en)
CA (1) CA2465570A1 (en)
EC (1) ECSP045121A (en)
TW (1) TWI242568B (en)
WO (1) WO2003047752A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2482640A1 (en) * 2002-06-03 2003-12-11 Univation Technologies, Llc Solid, particulated, spray dried, heterogenous catalyst composition
CN1328310C (en) * 2004-11-05 2007-07-25 中国科学院化学研究所 Polyolefin composite material and preparation method
WO2006063501A1 (en) 2004-12-17 2006-06-22 Yangzi Petrochemical Company Co., Ltd. Supported non-metallocene olefin polymerization catalyst, and preparation and use thereof
US7323526B2 (en) * 2005-07-29 2008-01-29 Univation Technologies, Llc Supported metallocene-alkyl catalyst composition
WO2009052700A1 (en) 2007-10-16 2009-04-30 Sinopec Yangzi Petrochemical Company Ltd. Supported non-metallocene catalyst and its preparation method
JP5480148B2 (en) 2007-10-16 2014-04-23 中国石化揚子石油化工有限公司 Magnesium compound-supported nonmetallocene catalyst and production thereof
EP2196480A1 (en) 2008-12-15 2010-06-16 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Supported catalyst
CN104448066B (en) * 2014-12-16 2017-07-07 华东理工大学 A kind of many metal olefin polymerization catalysts of support type and preparation method and application
KR102637868B1 (en) 2015-07-08 2024-02-16 셰브론 필립스 케미컬 컴퍼니 엘피 Ziegler-Natta-Metallocene Dual Catalyst Systems With Activator-Supports
US9540457B1 (en) 2015-09-24 2017-01-10 Chevron Phillips Chemical Company Lp Ziegler-natta—metallocene dual catalyst systems with activator-supports
KR102509777B1 (en) * 2016-09-29 2023-03-16 다우 글로벌 테크놀로지스 엘엘씨 How to polymerize olefins
BR112019025053B1 (en) * 2017-06-02 2022-12-20 Univation Technologies, Llc METHOD FOR DETERMINING A RELATIVE DECREASE IN THE CATALYTIC EFFECTIVENESS OF A CATALYST AND METHOD FOR OFFSETTING A POLYMERIZATION REACTOR IN A POLYMERIZATION REACTOR
TWI785263B (en) 2018-08-02 2022-12-01 奧地利商柏列利斯股份公司 Process for polymerizing ethylene in a multi-stage polymerization process
CN114901391B (en) * 2019-11-26 2024-11-26 埃克森美孚化学专利公司 System and method for producing supported catalysts

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Also Published As

Publication number Publication date
WO2003047752A1 (en) 2003-06-12
CN1625440A (en) 2005-06-08
AU2002365867A1 (en) 2003-06-17
CN101062959A (en) 2007-10-31
JP2005511802A (en) 2005-04-28
BR0214554A (en) 2004-11-09
EP1461151A4 (en) 2010-03-24
KR20050033542A (en) 2005-04-12
CA2465570A1 (en) 2003-06-12
TWI242568B (en) 2005-11-01
US20050003950A1 (en) 2005-01-06
CN100584462C (en) 2010-01-27
EP1461151A1 (en) 2004-09-29
AR036903A1 (en) 2004-10-13

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