ECSP045213A - Aminas de fenilpirimidina como inhibidores ige - Google Patents

Aminas de fenilpirimidina como inhibidores ige

Info

Publication number
ECSP045213A
ECSP045213A EC2004005213A ECSP045213A ECSP045213A EC SP045213 A ECSP045213 A EC SP045213A EC 2004005213 A EC2004005213 A EC 2004005213A EC SP045213 A ECSP045213 A EC SP045213A EC SP045213 A ECSP045213 A EC SP045213A
Authority
EC
Ecuador
Prior art keywords
phenyl pyrimidine
ige inhibitors
pyrimidine amines
amines
phenyl
Prior art date
Application number
EC2004005213A
Other languages
English (en)
Inventor
Murty Bulusu
Peter Ettmayer
Klaus Weigand
Max Woisetschalaeger
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0202381A external-priority patent/GB0202381D0/en
Priority claimed from GB0221953A external-priority patent/GB0221953D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP045213A publication Critical patent/ECSP045213A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Una amina, la cual se sustituye por pirimidina sustituida por fenilo; y fenilo; y un tercer sustituyente y su uso como una preparación farmacéutica.
EC2004005213A 2002-02-01 2004-07-30 Aminas de fenilpirimidina como inhibidores ige ECSP045213A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0202381A GB0202381D0 (en) 2002-02-01 2002-02-01 Organic compounds
GB0221953A GB0221953D0 (en) 2002-09-20 2002-09-20 Organic compounds

Publications (1)

Publication Number Publication Date
ECSP045213A true ECSP045213A (es) 2004-09-28

Family

ID=27665364

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005213A ECSP045213A (es) 2002-02-01 2004-07-30 Aminas de fenilpirimidina como inhibidores ige

Country Status (23)

Country Link
US (2) US20050119255A1 (es)
EP (1) EP1474146B1 (es)
JP (1) JP4393198B2 (es)
KR (1) KR20040081159A (es)
CN (2) CN1622807A (es)
AR (1) AR038368A1 (es)
AT (1) ATE406165T1 (es)
AU (1) AU2003206810B2 (es)
BR (1) BR0307379A (es)
CA (1) CA2471883C (es)
DE (1) DE60323205D1 (es)
EC (1) ECSP045213A (es)
ES (1) ES2312749T3 (es)
IL (1) IL162766A0 (es)
MX (1) MXPA04007395A (es)
NO (1) NO20043610L (es)
NZ (1) NZ534229A (es)
PE (1) PE20030983A1 (es)
PL (1) PL370666A1 (es)
PT (1) PT1474146E (es)
RU (1) RU2004126614A (es)
TW (1) TW200302728A (es)
WO (1) WO2003063871A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050014753A1 (en) * 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
EP1648875A1 (en) * 2003-07-30 2006-04-26 Cyclacel Limited 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
US20070099938A1 (en) * 2003-10-24 2007-05-03 Ono Pharmaceutical Co., Ltd. Antistress drug and medical use thereof
EP1933839A1 (en) * 2005-09-29 2008-06-25 Novartis AG Phenyl-(4-phenyl-pyrimidin-2-yl)-amines for enhancing immunotolerance
US8088793B2 (en) 2007-08-15 2012-01-03 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
CA3162388A1 (en) 2019-12-20 2021-06-24 Alfredo C. Castro 4-phenyl-n-(phenyl)thiazol-2-amine derivatives and related compounds as aryl hydrocarbon receptor (ahr) agonists for the treatment of e.g. angiogenesis implicated or inflammatory disorder
KR20240159754A (ko) * 2023-04-28 2024-11-06 한국원자력의학원 N-메틸피페라진 에탄올 카바메이트(N-methylpiperazine ethanol carbamate) 구조를 포함하는 신규 화합물 및 이의 용도

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1185039A (en) 1966-03-31 1970-03-18 Ici Ltd Pyrimidine Derivatives and Compositions containing them
GB2001069B (en) 1977-07-12 1982-01-20 Scras Pyrimidine derivatives
AU5319479A (en) 1978-12-22 1980-06-26 Ici Australia Limited Pyrimidinyl amino phenoxy carboxylate derivatives
US4351939A (en) * 1980-10-16 1982-09-28 Mead Johnson & Company Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
EP0084194B1 (de) * 1982-01-14 1986-04-30 MERCK PATENT GmbH Flüssigkristallmischungen
FR2536071B1 (fr) 1982-11-12 1986-07-11 Sanofi Sa Sels acides de 2-piperazinopyrimidine, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2547821B1 (fr) * 1983-06-24 1985-12-06 Sanofi Sa Sel de 2-piperazinopyrimidine, procede pour sa preparation et compositions pharmaceutiques en contenant
US4659363A (en) 1983-07-25 1987-04-21 Ciba-Geigy Corporation N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
EP0164204A1 (en) 1984-05-12 1985-12-11 FISONS plc Novel pharmaceutically useful pyrimidines
EP0172786B1 (de) * 1984-06-25 1991-01-30 Ciba-Geigy Ag Pyrimidinderivate wirksam als Schädlingsbekämpfungsmittel
ES2087056T3 (es) 1986-01-13 1996-07-16 American Cyanamid Co 2-pirimidinaminas sustituidas en las posiciones 4, 5 y 6.
DE3614060A1 (de) 1986-04-23 1987-10-29 Schering Ag Pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
US4868183A (en) 1986-07-21 1989-09-19 Otsuka Pharmaceutical Factory, Inc. N-pyrazinyl substituted P-aminophenols
EP0264348B1 (de) * 1986-10-13 1993-12-15 Ciba-Geigy Ag Harnstoffe
US4826990A (en) 1987-09-30 1989-05-02 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
US4966622A (en) * 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
DE58905007D1 (de) * 1988-04-12 1993-09-02 Ciba Geigy Ag Harnstoffe.
US4973690A (en) * 1988-04-12 1990-11-27 Ciba-Geigy Corporation Novel ureas
JPH02308248A (ja) * 1989-05-24 1990-12-21 Fuji Photo Film Co Ltd アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
US5516775A (en) * 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
PT672041E (pt) 1993-10-01 2002-04-29 Novartis Ag Derivados da piridina farmacologicamente activos e processos para a sua preparacao
WO1995009851A1 (en) 1993-10-01 1995-04-13 Ciba-Geigy Ag Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof
WO1995009847A1 (en) 1993-10-01 1995-04-13 Ciba-Geigy Ag Pyrimidineamine derivatives and processes for the preparation thereof
BR9407799A (pt) * 1993-10-12 1997-05-06 Du Pont Merck Pharma Composição de matéria método de tratamento e composição farmaceutica
JP2896532B2 (ja) 1994-08-13 1999-05-31 ユーハン コーポレーション 新規なピリミジン誘導体およびその製造方法
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
TW520362B (en) 1996-12-05 2003-02-11 Amgen Inc Substituted pyrimidine compounds and pharmaceutical composition comprising same
DK0976745T3 (da) * 1997-03-26 2003-10-27 Taisho Pharmaceutical Co Ltd 4-tetrahydropyridylpyrimidinderivat
IN188411B (es) 1997-03-27 2002-09-21 Yuhan Corp
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
PE20000174A1 (es) * 1998-01-12 2000-03-17 Novartis Ag Piridinilpirimidinaminas
ID24959A (id) * 1998-01-28 2000-08-31 Shionogi & Co Senyawa-senyawa trisiklik yang baru
EA002973B1 (ru) 1998-03-27 2002-12-26 Янссен Фармацевтика Н.В. Производные пиримидина в качестве ингибиторов репликации вируса иммунодефицита человека
AR023052A1 (es) 1998-09-25 2002-09-04 Mitsuharu Yoshimura Milton Derivados de pirimidona
US6576631B1 (en) * 1998-11-17 2003-06-10 Kumiai Chemical Industry Co., Ltd. Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural bactericides
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
ATE365158T1 (de) 1999-04-28 2007-07-15 Inst Med Molecular Design Inc Pyrimidincarbonsäurederivate
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
GB0003224D0 (en) 2000-02-11 2000-04-05 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
US7759357B2 (en) 2010-07-20
JP4393198B2 (ja) 2010-01-06
JP2005516051A (ja) 2005-06-02
PL370666A1 (en) 2005-05-30
CA2471883A1 (en) 2003-08-07
AU2003206810B2 (en) 2006-06-29
NO20043610L (no) 2004-10-05
US20070281956A1 (en) 2007-12-06
CA2471883C (en) 2010-12-07
PE20030983A1 (es) 2004-01-26
ES2312749T3 (es) 2009-03-01
EP1474146B1 (en) 2008-08-27
WO2003063871A1 (en) 2003-08-07
ATE406165T1 (de) 2008-09-15
BR0307379A (pt) 2004-12-28
CN101684097A (zh) 2010-03-31
PT1474146E (pt) 2008-12-05
MXPA04007395A (es) 2005-06-17
KR20040081159A (ko) 2004-09-20
TW200302728A (en) 2003-08-16
NZ534229A (en) 2005-04-29
AR038368A1 (es) 2005-01-12
RU2004126614A (ru) 2005-05-27
EP1474146A1 (en) 2004-11-10
IL162766A0 (en) 2005-11-20
DE60323205D1 (en) 2008-10-09
US20050119255A1 (en) 2005-06-02
CN1622807A (zh) 2005-06-01

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