ECSP045290A - Proceso para la síntesis de piperazinas n-arílicas quirales. - Google Patents
Proceso para la síntesis de piperazinas n-arílicas quirales.Info
- Publication number
- ECSP045290A ECSP045290A EC2004005290A ECSP045290A ECSP045290A EC SP045290 A ECSP045290 A EC SP045290A EC 2004005290 A EC2004005290 A EC 2004005290A EC SP045290 A ECSP045290 A EC SP045290A EC SP045290 A ECSP045290 A EC SP045290A
- Authority
- EC
- Ecuador
- Prior art keywords
- aryl
- chiral
- piperazins
- synthesis
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- -1 2-aminopyridyl Chemical group 0.000 abstract 2
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 238000006073 displacement reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Un proceso para la preparación de piperazinas N-arílicas con cadenas laterales quirales que tienen la estructura que se muestra en la fórmula abajo, y para la preparación de compuestos intermedios para las mismas: (Fórmula I). En este proceso, se introduce la quiralidad en el paso de formación del anillo de piperazina y la sustitución de 2-aminopiridilo se incorpora mediante desplazamiento. Las piperazinas N,N'-disustituidas resultantes actúan en el sistema nervioso central en los receptores de 5HT.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36343102P | 2002-03-12 | 2002-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045290A true ECSP045290A (es) | 2004-10-26 |
Family
ID=28041762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2004005290A ECSP045290A (es) | 2002-03-12 | 2004-09-10 | Proceso para la síntesis de piperazinas n-arílicas quirales. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6713626B2 (es) |
| EP (1) | EP1483255B1 (es) |
| JP (1) | JP4391241B2 (es) |
| KR (1) | KR20040105765A (es) |
| CN (2) | CN1982307A (es) |
| AR (1) | AR038930A1 (es) |
| AT (1) | ATE439356T1 (es) |
| AU (1) | AU2003220094B2 (es) |
| BR (1) | BR0308377A (es) |
| CA (1) | CA2477892C (es) |
| CR (1) | CR7431A (es) |
| DE (1) | DE60328756D1 (es) |
| EC (1) | ECSP045290A (es) |
| ES (1) | ES2329122T3 (es) |
| IL (1) | IL163827A0 (es) |
| MX (1) | MXPA04008729A (es) |
| NO (1) | NO20044050L (es) |
| NZ (1) | NZ535168A (es) |
| RU (1) | RU2315762C2 (es) |
| TW (1) | TW200403231A (es) |
| UA (1) | UA79273C2 (es) |
| WO (1) | WO2003078417A1 (es) |
| ZA (1) | ZA200408202B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060287335A1 (en) * | 2000-11-28 | 2006-12-21 | Wyeth | Serotonergic agents for treating sexual dysfunction |
| US20060223824A1 (en) * | 2000-11-28 | 2006-10-05 | Wyeth | Serotonergic agents |
| DK1408976T5 (da) | 2001-07-20 | 2011-01-10 | Psychogenics Inc | Behandling af ADHD (Attention deficit hyperactivity disorder) |
| US7361773B2 (en) * | 2002-03-12 | 2008-04-22 | Wyeth | Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines |
| US7091349B2 (en) * | 2002-03-12 | 2006-08-15 | Wyeth | Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution |
| TWI288642B (en) * | 2002-03-12 | 2007-10-21 | Wyeth Corp | Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines |
| JP2005527530A (ja) * | 2002-03-12 | 2005-09-15 | ワイス | キラル１，４−二置換ピペラジン |
| US20070099931A1 (en) * | 2004-03-19 | 2007-05-03 | Wyeth | Pharmaceutical dosage forms and compositions |
| US20050209245A1 (en) * | 2004-03-19 | 2005-09-22 | Wyeth | Process for preparing N-aryl-piperazine derivatives |
| US20050215561A1 (en) * | 2004-03-19 | 2005-09-29 | Krishnendu Ghosh | Pharmaceutical dosage forms and compositions |
| BRPI0609370A2 (pt) * | 2005-03-01 | 2010-03-30 | Wyeth Corp | cloridrato de 4-ciano-n-{(2r)-2-[4-(2,3-dihidro-benzo[1,4]dioxin-5-il)-pip erazin-1-il]-propil}-n-piridin-2-il-benzamida cristalino e amorfo |
| CN117003693B (zh) * | 2022-05-05 | 2026-01-30 | 四川大学华西医院 | 一类哌啶衍生物及其制备方法和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3586794T2 (de) | 1984-12-21 | 1993-05-27 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| JPH01125357A (ja) | 1987-11-06 | 1989-05-17 | Dainippon Pharmaceut Co Ltd | トリペプチドの誘導体 |
| AU645681B2 (en) * | 1991-05-02 | 1994-01-20 | John Wyeth & Brother Limited | Piperazine derivatives |
| GB9125900D0 (en) * | 1991-12-05 | 1992-02-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
| WO1994024115A1 (fr) * | 1993-04-16 | 1994-10-27 | Santen Pharmaceutical Co., Ltd. | Nouveau derive de piperazine |
| GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
| DK0763024T3 (da) | 1994-06-03 | 2002-12-02 | Wyeth John & Brother Ltd | Fremgangmåde og mellemprodukter til fremstilling af piperazinderivater |
| GB9413772D0 (en) * | 1994-07-08 | 1994-08-24 | Wyeth John & Brother Ltd | 5-HT1A ligands |
| GB9514901D0 (en) * | 1995-07-20 | 1995-09-20 | American Home Prod | Piperazine derivatives |
| WO1997037655A1 (en) | 1996-04-10 | 1997-10-16 | Merck & Co., Inc. | αvβ3 ANTAGONISTS |
| US6469007B2 (en) | 2000-11-28 | 2002-10-22 | Wyeth | Serotonergic agents |
-
2003
- 2003-03-10 US US10/384,845 patent/US6713626B2/en not_active Expired - Fee Related
- 2003-03-10 EP EP03716384A patent/EP1483255B1/en not_active Expired - Lifetime
- 2003-03-10 CN CNA2007100083292A patent/CN1982307A/zh active Pending
- 2003-03-10 IL IL16382703A patent/IL163827A0/xx unknown
- 2003-03-10 NZ NZ535168A patent/NZ535168A/xx unknown
- 2003-03-10 WO PCT/US2003/007078 patent/WO2003078417A1/en not_active Ceased
- 2003-03-10 ES ES03716384T patent/ES2329122T3/es not_active Expired - Lifetime
- 2003-03-10 DE DE60328756T patent/DE60328756D1/de not_active Expired - Lifetime
- 2003-03-10 BR BR0308377-2A patent/BR0308377A/pt not_active IP Right Cessation
- 2003-03-10 AU AU2003220094A patent/AU2003220094B2/en not_active Expired - Fee Related
- 2003-03-10 RU RU2004130300/04A patent/RU2315762C2/ru not_active IP Right Cessation
- 2003-03-10 CA CA2477892A patent/CA2477892C/en not_active Expired - Fee Related
- 2003-03-10 AT AT03716384T patent/ATE439356T1/de not_active IP Right Cessation
- 2003-03-10 KR KR10-2004-7014156A patent/KR20040105765A/ko not_active Ceased
- 2003-03-10 TW TW092105097A patent/TW200403231A/zh unknown
- 2003-03-10 JP JP2003576423A patent/JP4391241B2/ja not_active Expired - Fee Related
- 2003-03-10 MX MXPA04008729A patent/MXPA04008729A/es active IP Right Grant
- 2003-03-10 CN CNB038058413A patent/CN1304388C/zh not_active Expired - Fee Related
- 2003-03-11 AR ARP030100831A patent/AR038930A1/es unknown
- 2003-10-03 UA UA20041008211A patent/UA79273C2/uk unknown
-
2004
- 2004-08-24 CR CR7431A patent/CR7431A/es not_active Application Discontinuation
- 2004-09-10 EC EC2004005290A patent/ECSP045290A/es unknown
- 2004-09-24 NO NO20044050A patent/NO20044050L/no not_active Application Discontinuation
- 2004-10-11 ZA ZA200408202A patent/ZA200408202B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200403231A (en) | 2004-03-01 |
| NZ535168A (en) | 2006-03-31 |
| CN1982307A (zh) | 2007-06-20 |
| BR0308377A (pt) | 2005-01-11 |
| IL163827A0 (en) | 2005-12-18 |
| RU2004130300A (ru) | 2005-04-10 |
| NO20044050L (no) | 2004-09-24 |
| ATE439356T1 (de) | 2009-08-15 |
| UA79273C2 (en) | 2007-06-11 |
| AU2003220094A1 (en) | 2003-09-29 |
| JP4391241B2 (ja) | 2009-12-24 |
| EP1483255A1 (en) | 2004-12-08 |
| US20030187265A1 (en) | 2003-10-02 |
| AR038930A1 (es) | 2005-02-02 |
| KR20040105765A (ko) | 2004-12-16 |
| CA2477892A1 (en) | 2003-09-25 |
| RU2315762C2 (ru) | 2008-01-27 |
| EP1483255B1 (en) | 2009-08-12 |
| ZA200408202B (en) | 2007-03-28 |
| US6713626B2 (en) | 2004-03-30 |
| JP2005526775A (ja) | 2005-09-08 |
| CR7431A (es) | 2008-07-29 |
| ES2329122T3 (es) | 2009-11-23 |
| DE60328756D1 (de) | 2009-09-24 |
| MXPA04008729A (es) | 2005-07-13 |
| CN1304388C (zh) | 2007-03-14 |
| CA2477892C (en) | 2010-11-23 |
| AU2003220094B2 (en) | 2009-04-23 |
| CN1642936A (zh) | 2005-07-20 |
| WO2003078417A1 (en) | 2003-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2111650T3 (es) | Derivados aciclicos de etilenodiamina como antagonistas de receptores de la sustancia p. | |
| ECSP045290A (es) | Proceso para la síntesis de piperazinas n-arílicas quirales. | |
| ECSP066520A (es) | Derivados de dihidrobenzofuranilo alcanamina y métodos para su uso | |
| AR030533A1 (es) | Compuestos derivados de biarileter utiles como inhibidores de la recaptacion de monoaminas, composicion farmaceutica, procedimiento de tratamiento intermediario | |
| MX9605128A (es) | Nuevos derivados de aminoacidos, procedimientos para su preparacion y composiciones farmaceuticas que contienen estos compuestos. | |
| ES2135414T3 (es) | Antagonistas del receptor 5-ht4. | |
| NO20032253D0 (no) | Piperazinylpyrazinforbindelser som antagonister av serotonin 5-HT2-reseptorer | |
| HRP20060449T3 (en) | Process for the preparation of (1s)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane, acid additon salts thereof and its use for the synthesis of ivabradine and for its pharmaceutically acceptable acid addition salts | |
| AR029821A1 (es) | Decahidro-isoquinolinas, un proceso para su preparacion, composiciones farmaceuticas que las comprenden y el uso de las mismas para la fabricacion de un medicamento | |
| AR068413A2 (es) | Derivados 8-amino, metodos de preparacion, composiciones farmaceuticas y su uso en terapia | |
| MX2007013021A (es) | Derivados de benzofuranil-alcanamina y usos de los mismos como agonistas de 5-ht2c. | |
| PE20060689A1 (es) | Derivados de sulfonamidas como antagonistas de receptores orexina 2 | |
| EA200300619A1 (ru) | Серотонинергические средства | |
| UY28765A1 (es) | Compuestos de piperazina acetilínica y su uso como antagonistas del receptor de glutamato metabotrópico | |
| FR2801585B1 (fr) | Nouveaux antagonistes des recepteurs de l'ii-8 | |
| AR028743A1 (es) | DERIVADOS DE N-TRIAZOLILMETIL-PIPERAZINA CON ACCIoN ANTAGONISTA DE RECEPTORES DE NEUROQUININA | |
| DK0664807T3 (da) | Quinoxalindionderivater som EAA-antagonister | |
| ECSP045291A (es) | Preparación de ácido n1-(2'-piridil)-1,2-propanodiamino sulfámico y su uso en la síntesis de piperazinas biológicamente activas | |
| CR6503A (es) | Derivados de- 1-trifluorometil-4-hidroxi-7-piperidinil-aminometiclcromano | |
| ECSP045292A (es) | Proceso para la preparación de piperazines quirales 1,4-disustituidas | |
| PT1430034E (pt) | Derivados de alquilaminopiridazinona substituida processo para sua preparacao e composicoes farmaceuticas que os contem | |
| AR030373A1 (es) | Profarmacos para el tratamiento de enfermedades relacionadas con el receptor del nmda | |
| EA200701758A1 (ru) | Замещённые арильные производные 1,4-пиразина | |
| EA200500237A1 (ru) | Новый способ синтеза соединений 1,3-дигидро-2h-3-бензазепин-2-она и применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой | |
| DE60315626D1 (de) | Kondensierte bicyclische pyrimidinderivate |