ECSP045350A - 5- {2-HIDROXI-3-1- (3-TRIFLUOROMETILFENIL) -CICLOPROPIL-PROPIONILAMINO} -FALIDA AND COMPOUNDS RELATED TO MODULATOR ACTIVITY OF THE PROGESTERONE RECEPTOR TO BE EMPLOYED IN THE CONTRACEPTION AND IN A HORMAL REPLACEMENT THERAPY - Google Patents
5- {2-HIDROXI-3-1- (3-TRIFLUOROMETILFENIL) -CICLOPROPIL-PROPIONILAMINO} -FALIDA AND COMPOUNDS RELATED TO MODULATOR ACTIVITY OF THE PROGESTERONE RECEPTOR TO BE EMPLOYED IN THE CONTRACEPTION AND IN A HORMAL REPLACEMENT THERAPYInfo
- Publication number
- ECSP045350A ECSP045350A ECSP045350A ECSP045350A EC SP045350 A ECSP045350 A EC SP045350A EC SP045350 A ECSP045350 A EC SP045350A EC SP045350 A ECSP045350 A EC SP045350A
- Authority
- EC
- Ecuador
- Prior art keywords
- progesterone receptor
- contraception
- trifluorometilfenil
- propionilamino
- falida
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 3
- 102000003998 progesterone receptors Human genes 0.000 title abstract 3
- 108090000468 progesterone receptors Proteins 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- 238000009256 replacement therapy Methods 0.000 title 1
- 239000000583 progesterone congener Substances 0.000 abstract 3
- 230000001404 mediated effect Effects 0.000 abstract 2
- 210000000481 breast Anatomy 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 230000003054 hormonal effect Effects 0.000 abstract 1
- 229940127234 oral contraceptive Drugs 0.000 abstract 1
- 239000003539 oral contraceptive agent Substances 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención consiste en progestinas no esteroides de la fórmula general (I) donde R1 y R2 son, independientemente entre sí, -H o -F, R3 es -CH3 o -CF3, y Ar es (a) o (b), o un derivado o análogo del mismo aceptable para uso farmacéutico. Estas progestinas son adecuadas para modular selectivamente los efectos mediados por el receptor de progesterona en diferentes tejidos de interés, en particular en tejidos de útero versus tejido de mama. Por ello, las progestinas de la presente invención, optativamente en combinación con estrógenos, se pueden utilizar en la contracepción (en particular en los anticonceptivos orales libres de estrógenos), para reemplazo hormonal y para trastornos ginecológicos. La presente invención se relaciona además con una forma de modular selectivamente los efectos mediados por el receptor de progesterona en diferentes tejidos u órganos de interés.The present invention consists of non-steroidal progestins of the general formula (I) where R1 and R2 are, independently of each other, -H or -F, R3 is -CH3 or -CF3, and Ar is (a) or (b), or a derivative or analog thereof acceptable for pharmaceutical use. These progestins are suitable for selectively modulating the effects mediated by the progesterone receptor in different tissues of interest, in particular in uterine tissues versus breast tissue. Therefore, the progestins of the present invention, optionally in combination with estrogens, can be used in contraception (in particular in estrogen-free oral contraceptives), for hormonal replacement and for gynecological disorders. The present invention also relates to a way of selectively modulating the effects mediated by the progesterone receptor in different tissues or organs of interest.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP045350 ECSP045350A (en) | 2004-10-08 | 2004-10-08 | 5- {2-HIDROXI-3-1- (3-TRIFLUOROMETILFENIL) -CICLOPROPIL-PROPIONILAMINO} -FALIDA AND COMPOUNDS RELATED TO MODULATOR ACTIVITY OF THE PROGESTERONE RECEPTOR TO BE EMPLOYED IN THE CONTRACEPTION AND IN A HORMAL REPLACEMENT THERAPY |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP045350 ECSP045350A (en) | 2004-10-08 | 2004-10-08 | 5- {2-HIDROXI-3-1- (3-TRIFLUOROMETILFENIL) -CICLOPROPIL-PROPIONILAMINO} -FALIDA AND COMPOUNDS RELATED TO MODULATOR ACTIVITY OF THE PROGESTERONE RECEPTOR TO BE EMPLOYED IN THE CONTRACEPTION AND IN A HORMAL REPLACEMENT THERAPY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045350A true ECSP045350A (en) | 2004-11-26 |
Family
ID=40419306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP045350 ECSP045350A (en) | 2004-10-08 | 2004-10-08 | 5- {2-HIDROXI-3-1- (3-TRIFLUOROMETILFENIL) -CICLOPROPIL-PROPIONILAMINO} -FALIDA AND COMPOUNDS RELATED TO MODULATOR ACTIVITY OF THE PROGESTERONE RECEPTOR TO BE EMPLOYED IN THE CONTRACEPTION AND IN A HORMAL REPLACEMENT THERAPY |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP045350A (en) |
-
2004
- 2004-10-08 EC ECSP045350 patent/ECSP045350A/en unknown
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