ECSP045489A - AMIDES OF 2-HETEROARILCARBOXILIC ACIDS - Google Patents
AMIDES OF 2-HETEROARILCARBOXILIC ACIDSInfo
- Publication number
- ECSP045489A ECSP045489A EC2004005489A ECSP045489A ECSP045489A EC SP045489 A ECSP045489 A EC SP045489A EC 2004005489 A EC2004005489 A EC 2004005489A EC SP045489 A ECSP045489 A EC SP045489A EC SP045489 A ECSP045489 A EC SP045489A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- trifluoromethoxy
- solvates
- heteroaryl
- trifluoromethyl
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title abstract 2
- -1 1-azabicyclo [2.2.2] oct-3-yl Chemical group 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000008447 perception Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a nuevas amidas de ácidos 2-heteroarilcarboxílicos y a su uso para la preparación de medicamentos para el tratamiento y/o la profilaxis de enfermedades y para la mejora de la percepción, la capacidad de concentración, la capacidad de aprendizaje y/o la capacidad de memoria. en la que R1 significa 1-azabiciclo[2.2.2]oct-3-ilo, que está eventualmente sustituido en el átomo de nitrógeno con un resto seleccionado del grupo de alquilo C1-C4, bencilo u oxi; A significa oxígeno o azufre; el anillo B significa benzo o pirido, que están eventualmente sustituidos con restos del grupo de halógeno, ciano, formilo, trifluorometilo, trifluorometoxi, nitro, amino, alquilo C1-C6 y alcoxi C1-C6; E significa C=C, arilo y heteroarilo, pudiendo estar el arilo y heteroarilo sustituidos con restos del grupo de halógeno, ciano, trifluorometilo, trifluorometoxi, nitro, amino, alcoxi C1-C6 y alquilo C1-C6; así como los solvatos, sales y solvatos de las sales de estos compuestos.The invention relates to new amides of 2-heteroarylcarboxylic acids and their use for the preparation of medicaments for the treatment and / or prophylaxis of diseases and for the improvement of perception, ability to concentrate, learning capacity and / or memory capacity wherein R1 means 1-azabicyclo [2.2.2] oct-3-yl, which is optionally substituted on the nitrogen atom with a moiety selected from the group of C1-C4 alkyl, benzyl or oxy; A means oxygen or sulfur; Ring B means benzo or pyrido, which are optionally substituted with halogen, cyano, formyl, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6 alkyl and C1-C6 alkoxy groups; E means C = C, aryl and heteroaryl, the aryl and heteroaryl being substituted by halogen, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6 alkoxy and C1-C6 alkyl groups; as well as the solvates, salts and solvates of the salts of these compounds.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10225536 | 2002-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045489A true ECSP045489A (en) | 2005-01-28 |
Family
ID=31196835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2004005489A ECSP045489A (en) | 2002-06-10 | 2004-12-10 | AMIDES OF 2-HETEROARILCARBOXILIC ACIDS |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE10305922A1 (en) |
| EC (1) | ECSP045489A (en) |
| ZA (1) | ZA200409883B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05003317A (en) | 2002-09-25 | 2005-07-05 | Memory Pharm Corp | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof. |
| RU2389729C2 (en) | 2003-12-22 | 2010-05-20 | Мемори Фармасьютиклз Корпорейшн | 1h-indazoles, 1,2-benzisoxazoles and 1,2-benzisothiazoles, synthesis thereof and use |
| EP1735306A2 (en) | 2004-03-25 | 2006-12-27 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| CA2567977A1 (en) | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
| NZ551712A (en) | 2004-05-07 | 2010-07-30 | Memory Pharm Corp | 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparations and uses thereof |
| GB2418426A (en) | 2004-08-18 | 2006-03-29 | Univ Cambridge Tech | Alpha-(acylamino)-bicyclolactam derivatives for treatment of inflammatory disorders |
| GB2418427A (en) | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
| CA2591817A1 (en) | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
| US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
-
2003
- 2003-02-13 DE DE10305922A patent/DE10305922A1/en not_active Withdrawn
-
2004
- 2004-12-07 ZA ZA200409883A patent/ZA200409883B/en unknown
- 2004-12-10 EC EC2004005489A patent/ECSP045489A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200409883B (en) | 2006-02-22 |
| DE10305922A1 (en) | 2004-03-04 |
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